NADPH-cytochrome P450 reductase

WordNet

1. an enzyme that catalyses the biochemical reduction of some specified substance
2. (biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 副腎ステロイド生合成 adrenal steroid biosynthesis
• 2. 脳腱黄色腫症 cerebrotendinous xanthomatosis
• 3. 副腎ステロイドの代謝 metabolism of adrenal steroids
• 4. 自然免疫系の概要 an overview of the innate immune system
• 5. 肝線維症の病因 pathogenesis of hepatic fibrosis

English Journal

• Cytochrome P450 17A1 Interactions with the FMN Domain of its Reductase as Characterized by NMR.

• Estrada DF1, Laurence JS1, Scott EE2.
• The Journal of biological chemistry.J Biol Chem.2015 Dec 30. pii: jbc.M115.677294. [Epub ahead of print]
• To accomplish key physiological processes from drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequential input of two electrons delivered by the FMN domain of NADPH-cytochrome P450 reductase (CPR). Although some human microsomal P450 enzymes can instead acce
• PMID 26719338

• Effect of Age on the Hepatocellularity Number for Wistar Rats.

• Fattah S1, Augustijns P1, Annaert PP2.
• Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec 23. pii: dmd.115.066381. [Epub ahead of print]
• Recently there has been a substantial increase in the number of juvenile animal toxicity studies that are conducted to support paediatric drug safety evaluation. Adequate design of juvenile toxicity studies in rats, for instance with respect to dose levels per age group, requires an understanding of
• PMID 26700957

• Functional characterization of NADPH-cytochrome P450 reductase from Bactrocera dorsalis: Possible involvement in susceptibility to malathion.

• Huang Y1, Lu XP1, Wang LL1, Wei D1, Feng ZJ1, Zhang Q1, Xiao LF1, Dou W1, Wang JJ1.
• Scientific reports.Sci Rep.2015 Dec 18;5:18394. doi: 10.1038/srep18394.
• NADPH cytochrome P450 reductase (CPR) is essential for cytochrome P450 catalysis, which is important in the detoxification and activation of xenobiotics. In this study, two transcripts of Bactrocera dorsalis CPR (BdCPR) were cloned, and the deduced amino-acid sequence had an N-terminus membrane anch
• PMID 26681597

Japanese Journal

• ヘム鉄代謝の鍵となる電子伝達複合体の構造解析

• 日本結晶学会誌 56(6), 393-398, 2014
• NAID 130004799692

• Mechanism-based Inactivation of Cytochrome P450 2A6 and 2A13 by <i>Rhinacanthus nasutus</i> Constituents

• Drug Metabolism and Pharmacokinetics 29(1), 75-82, 2014
• NAID 130004463346

• 活性酸素種生成に関与するシトクロームP450の病態生理学的役割

• YAKUGAKU ZASSHI 133(4), 435-450, 2013
• NAID 130003361937

Related Links

• NADPH Cytochrome P450 Reductase

About The NADPH-dependent cytochrome P450 reductase (CPR) is a membrane bound protein localized in the ER membrane. CPR is a multidomain protein with three cofactor binding domains (FMN, FAD and NADPH) and a linker ...

• CYTOCHROME P450 REDUCTASE

Overview of the biology, enzymology, and structure of cytochrome P450 reductase, an unusual electron transfer flavoprotein.

---

★リンクテーブル★

関連記事	「NADPH」「reductase」「NAD」「NADP」

「NADPH」

　　[★]

関

nicotinamide adenine dinucleotide phosphate

• グルタチオンの還元に必要。
• 足らなくなると、フリーラジカルや過酸化物を無毒化できなくなる。
• 赤血球の場合でNADPHが足らないと、fava beans, sulfonamides, primaquineおよび抗結核薬などの酸化剤によって溶血性貧血を起こす。

「reductase」

　　[★]

• n.

(酵素)還元酵素、レダクターゼ、リダクターゼ

関

dehydrogenase、oxidase、oxidoreductase、reducing enzyme

　

「NAD」

　　[★]

• ニコチンアミドアデニンジヌクレオチド nicotinamide adenine dinucleotide
• 異常所見なし nothing abnormal detected

「NADP」

　　[★] ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate