NADPH-cytochrome P450 reductase

出典: meddic

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  • Cytochrome P450 17A1 Interactions with the FMN Domain of its Reductase as Characterized by NMR.
  • Estrada DF1, Laurence JS1, Scott EE2.
  • The Journal of biological chemistry.J Biol Chem.2015 Dec 30. pii: jbc.M115.677294. [Epub ahead of print]
  • To accomplish key physiological processes from drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequential input of two electrons delivered by the FMN domain of NADPH-cytochrome P450 reductase (CPR). Although some human microsomal P450 enzymes can instead acce
  • PMID 26719338
  • Effect of Age on the Hepatocellularity Number for Wistar Rats.
  • Fattah S1, Augustijns P1, Annaert PP2.
  • Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec 23. pii: dmd.115.066381. [Epub ahead of print]
  • Recently there has been a substantial increase in the number of juvenile animal toxicity studies that are conducted to support paediatric drug safety evaluation. Adequate design of juvenile toxicity studies in rats, for instance with respect to dose levels per age group, requires an understanding of
  • PMID 26700957
  • Functional characterization of NADPH-cytochrome P450 reductase from Bactrocera dorsalis: Possible involvement in susceptibility to malathion.
  • Huang Y1, Lu XP1, Wang LL1, Wei D1, Feng ZJ1, Zhang Q1, Xiao LF1, Dou W1, Wang JJ1.
  • Scientific reports.Sci Rep.2015 Dec 18;5:18394. doi: 10.1038/srep18394.
  • NADPH cytochrome P450 reductase (CPR) is essential for cytochrome P450 catalysis, which is important in the detoxification and activation of xenobiotics. In this study, two transcripts of Bactrocera dorsalis CPR (BdCPR) were cloned, and the deduced amino-acid sequence had an N-terminus membrane anch
  • PMID 26681597


  • ヘム鉄代謝の鍵となる電子伝達複合体の構造解析
  • Mechanism-based Inactivation of Cytochrome P450 2A6 and 2A13 by <i>Rhinacanthus nasutus</i> Constituents
  • 活性酸素種生成に関与するシトクロームP450の病態生理学的役割


About The NADPH-dependent cytochrome P450 reductase (CPR) is a membrane bound protein localized in the ER membrane. CPR is a multidomain protein with three cofactor binding domains (FMN, FAD and NADPH) and a linker ...
Overview of the biology, enzymology, and structure of cytochrome P450 reductase, an unusual electron transfer flavoprotein.






nicotinamide adenine dinucleotide phosphate
  • グルタチオンの還元に必要。
  • 足らなくなると、フリーラジカルや過酸化物を無毒化できなくなる。
  • 赤血球の場合でNADPHが足らないと、fava beans, sulfonamides, primaquineおよび抗結核薬などの酸化剤によって溶血性貧血を起こす。



  • n.
dehydrogenaseoxidaseoxidoreductasereducing enzyme

WordNet   license wordnet

「an enzyme that catalyses the biochemical reduction of some specified substance」


  [★] シトクロム

WordNet   license wordnet

「(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)」




  [★] ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate