Meesmann corneal epithelial dystrophy

出典: meddic


juvenile epithelial of Meesmann corneal dystrophy

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  • siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
  • Courtney DG1, Atkinson SD1, Allen EH1, Moore JE1, Walsh CP1, Pedrioli DM2, MacEwen CJ3, Pellegrini G4, Maurizi E5, Serafini C4, Fantacci M4, Liao H2, Irvine AD6, McLean WH2, Moore CB7.
  • Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2014 May 6;55(5):3352-60. doi: 10.1167/iovs.13-12957.
  • PURPOSE: The aim of this study is to further assess our previously reported keratin 12 (K12)-Leu132Pro specific siRNA in silencing the mutant allele in Meesmann's Epithelial Corneal Dystrophy (MECD) in experimental systems more akin to the in vivo situation through simultaneous expression of both wi
  • PMID 24801514
  • KRT12 mutations and in vivo confocal microscopy in two Japanese families with Meesmann corneal dystrophy.
  • Ogasawara M1, Matsumoto Y2, Hayashi T3, Ohno K3, Yamada H4, Kawakita T2, Dogru M5, Shimazaki J6, Tsubota K2, Tsuneoka H3.
  • American journal of ophthalmology.Am J Ophthalmol.2014 Jan;157(1):93-102.e1. doi: 10.1016/j.ajo.2013.08.008. Epub 2013 Oct 5.
  • PURPOSE: To identify genetic mutations and study the corneal epithelium in Japanese patients with Meesmann corneal dystrophy.DESIGN: Laboratory investigation and prospective observational case series.METHODS: Slit-lamp biomicroscopy with fluorescein vital staining and in vivo confocal microscopy wer
  • PMID 24099278
  • Autosomal-dominant Meesmann epithelial corneal dystrophy without an exon mutation in the keratin-3 or keratin-12 gene in a Chinese family.
  • Cao W1, Yan M, Hao Q, Wang S, Wu L, Liu Q, Li M, Biddle FG, Wu W.
  • The Journal of international medical research.J Int Med Res.2013 Apr;41(2):511-8. doi: 10.1177/0300060513477306. Epub 2013 Mar 12.
  • Meesmann epithelial corneal dystrophy (MECD) is a dominantly inherited disorder, characterized by fragility of the anterior corneal epithelium and formation of intraepithelial microcysts. It has been described in a number of different ancestral groups. To date, all reported cases of MECD have been a
  • PMID 23569037


  • Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy


Meesmann corneal dystrophy is a rare genetic condition affecting the epithelial membrane of the cornea. A slit-lamp examination of the cornea shows diffuse clusters of tiny round cysts in the epithelial membrane. Overtime these cysts can ...


Corneal dystrophy , juvenileOphthalmic Atlas Images by Meesmann Epithelial Corneal DystrophyOphthalmic Atlas Images by  corneal dystrophy (Courtesy of Michel & External Diseases-Meesmann's Dystrophy

リンク元juvenile epithelial of Meesmann corneal dystrophy」「メースマン角膜上皮変性症」「Meesmann角膜上皮変性症

juvenile epithelial of Meesmann corneal dystrophy」



Meesmann corneal epithelial dystrophy



Meesmann corneal epithelial dystrophy



Meesmann corneal epithelial dystrophy



  • n.
  • (医)栄養失調、栄養失調症。(医)異栄養、異栄養症、ジフトロフィー

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「any degenerative disorder resulting from inadequate or faulty nutrition」

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「栄養障害 / 筋萎縮症,筋ジストロフィー(筋肉の退化・萎縮・運動障害などが起こる病気)」


  [★] 角膜

WordNet   license wordnet

「the transparent dome-shaped anterior portion of the outer covering of the eye; it covers the iris and pupil and is continuous with the sclera」

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  • 上皮の、上皮系の、上皮性の、上皮型の

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「of or belonging to the epithelium; "epithelial layer"」



  • adj.
  • 角膜の

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「of or related to the cornea」

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  • n.