MBP-associated serine protease

出典: meddic

mannose-binding protein-associated serine proteaseMASP

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  • The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.
  • Kozarcanin H1, Lood C2, Munthe-Fog L3, Sandholm K4, Hamad OA1, Bengtsson AA2, Skjoedt MO3, Huber-Lang M5, Garred P3, Ekdahl KN1,4, Nilsson B1.
  • Journal of thrombosis and haemostasis : JTH.J Thromb Haemost.2015 Nov 28. doi: 10.1111/jth.13208. [Epub ahead of print]
  • BACKGROUND: The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet ide
  • PMID 26614707
  • The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema.
  • Hansen CB1, Csuka D2, Munthe-Fog L1, Varga L2, Farkas H2, Hansen KM1, Koch C3, Skjødt K3, Garred P1, Skjoedt MO4.
  • Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Oct 15;195(8):3596-604. doi: 10.4049/jimmunol.1402838. Epub 2015 Sep 14.
  • C1 inhibitor (C1-INH) is known to form complexes with the lectin complement pathway serine proteases MASP-1 and MASP-2. Deficiency of C1-INH is associated with hereditary angioedema (HAE), an autosomal inherited disease characterized by swelling attacks caused by elevated levels of bradykinin. MASP-
  • PMID 26371246
  • Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.
  • Drentin N1, Conroy P1, Gunzburg MJ1, Pike RN2, Wijeyewickrema LC3.
  • Molecular immunology.Mol Immunol.2015 Oct;67(2 Pt B):287-93. doi: 10.1016/j.molimm.2015.06.011. Epub 2015 Jun 27.
  • The interaction between mannose-binding lectin [MBL]-associated serine protease-2 (MASP-2) and its first substrate, C4 is crucial to the lectin pathway of complement, which is vital for innate host immunity, but also involved in a number of inflammatory diseases. Recent data suggests that two areas
  • PMID 26130224


  • The Gly-54->Asp allelic form of human mannose-binding protein (MBP) fail to bind MBP-associated serine protease.


The Gly-54 -+ Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease. Misao MATSUSHITA,* R. Alan B. EZEKOWITZt and Teizo FUJITA*t. *Department of Biochemistry, Fukushima Medical ...



リンク元マンノース結合タンパク質関連セリンプロテアーゼ」「mannose-binding protein-associated serine protease」「MBP関連セリンプロテアーゼ



mannan-binding lectin-associated serine proteases, MASPs



mannose-binding protein-associated serine proteaseMBP-associated serine proteaseMASP

mannose-binding protein-associated serine protease」



MASPMBP-associated serine protease



MBP-associated serine protease



  • vt.
  • 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
  • vi.
  • 仲間/友人などとして交際する(with)。一つにまとめる、連合する
  • n.
  • 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
  • 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
  • 連想によって心に浮かぶ言葉/思い、連想物
  • adj.
  • 仲間の、同僚の。製紙機械員に次ぐ資格の
  • 付随する、連想される

WordNet   license wordnet

「having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"」

WordNet   license wordnet

「a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"」

WordNet   license wordnet

「a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"」

WordNet   license wordnet

「any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"」

PrepTutorEJDIC   license prepejdic

「〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…」

WordNet   license wordnet

「make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all"」
tie in, relate, link, colligate, link up, connect




  [★] プロテアーゼ

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「any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis」
peptidase, proteinase, proteolytic enzyme


  [★] メチオニン methionine

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「the 13th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic

「Mach number / mark[s] / Monsieur」


  [★] セリン


WordNet   license wordnet

「a sweetish crystalline amino acid involved in the synthesis by the body of cysteine」