出典: meddic


large multifunctional proteasome (?)

  • プロテアソームのサブユニット
  • MHC class Iに結合するペプチドの生成に関わる
  • インターフェロンの作用により発現が上昇する
  • プロテアソームには2つの状態が存在し、通常のプロテアソームとインターフェロンにより刺激を受けたときのプロテアソーム(immunoproteasome)がある。
  • immunoproteasomeは基質の特異性が変わり、疎水基のあとを切断するようになり、酸性残基の後は切断しにくくなる
MHC class Iに結合したり、TAPにより輸送されやすくなるペプチドである。


  • LMP2 (=b1i) (IMM.185)
  • LMP7 (=b5i) (IMM.185)


  • MHC class IIIのTAP1とTAP2の近くにコードされている。 (図:IMM.197)


  • MECL-1 (=b2i)
MHCとは別の部位にコードされているが、MHC classIに結合するペプチドを生成するプロテアソームのサブユニットの一つ。


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/23 03:16:00」(JST)

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  • The use of seemingly unrelated regression to predict the carcass composition of lambs.
  • Cadavez VA, Henningsen A.SourceMountain Research Center (CIMO), ESA-Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
  • Meat science.Meat Sci.2012 Dec;92(4):548-53. Epub 2012 May 30.
  • The aim of this study was to develop and evaluate models for predicting the carcass composition of lambs. Forty male lambs were slaughtered and their carcasses were cooled for 24 hours. The subcutaneous fat thickness was measured between the 12th and 13th rib and breast bone tissue thickness was tak
  • PMID 22721640
  • Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells.
  • Rasul AE, Nagy N, Sohlberg E, Adori M, Claesson HE, Klein G, Klein E.SourceDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Nobels väg 16, S-171 77 Stockholm, Sweden. Electronic address: eahsan.rasul@ki.se.
  • Journal of immunological methods.J Immunol Methods.2012 Nov 30;385(1-2):60-70. doi: 10.1016/j.jim.2012.08.008. Epub 2012 Aug 18.
  • Epstein Barr virus (EBV) is carried by almost all adults, mostly without clinical manifestations. Latent virus infection of B lymphocytes induces activation and proliferation that can be demonstrated in vitro. In healthy individuals, generation of EBV induced malignant proliferation is avoided by co
  • PMID 22921685
  • Highly sulfated chondroitin sulfates, a novel class of prognostic biomarkers in ovarian cancer tissue.
  • Vallen MJ, Massuger LF, Ten Dam GB, Bulten J, van Kuppevelt TH.SourceDepartment of Biochemistry, Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
  • Gynecologic oncology.Gynecol Oncol.2012 Oct;127(1):202-9. Epub 2012 Jun 23.
  • OBJECTIVE: Clinical decision making in ovarian cancer needs new (prognostic) biomarkers. Although the search for biomarkers has traditionally focused on tumor cells, their surrounding contains important information as well. Glycosaminoglycans, heterogeneous polysaccharides which are abundantly prese
  • PMID 22733095


  • Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma
  • Wakisaka Naohiro,Hirota Kyoko,Kondo Satoru,Sawada-Kitamura Seiko,Endo Kazuhira,Murono Shigeyuki,Yoshizaki Tomokazu
  • Oral Oncology 48(8), 703-708, 2012-08
  • … Furthermore, we tested whether Epstein-Barr virus (EBV)-latent membrane protein (LMP) 1 induces VEGF-C. … Forty-one patients with NPC were evaluated for expressions of VEGF-C and its receptor, VEGFR3, and LMP1 proteins and lymphatic vessel counts (LVC) highlighted by anti-podoplanin employing immunohistochemistry. … The VEGF-C induction by LMP1 was then tested with Western blotting and enzyme-linked immunosorbent assay in vitro. …
  • NAID 120003959476
  • LMP-1はEBV関連リンパ腫において形質細胞分化および溶解感染を抑制する
  • Current understanding and management of nasopharyngeal carcinoma
  • Yoshizaki Tomokazu,Ito Makoto,Murono Shigekyuki,Wakisaka Naohiro,Kondo Satoru,Endo Kazuhira
  • Auris Nasus Larynx 39(2), 137-144, 2012-04
  • LMP1, an EBV primary oncogene, upregulates each step of metastasis, and contribute to highly metastatic feature of NPC. …
  • NAID 120003959461


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