WordNet
- have or establish a relationship to; "She relates well to her peers"
- be in a relationship with; "How are these two observations related?" (同)interrelate
- give an account of; "The witness related the events"
- connected by kinship, common origin, or marriage
- being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces" (同)related to
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- (…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》
- 関係のある
- 蛋白(たんばく)質
- =sense organ / 受信装置
UpToDate Contents
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- 1. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
- 2. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
- 3. 急性冠症候群後の低比重リポ蛋白コレステロール（LDL)低下 low density lipoprotein cholesterol ldl c lowering after an acute coronary syndrome
- 4. 炭疽菌の微生物学、病因、および疫学 microbiology pathogenesis and epidemiology of anthrax
- 5. 薬剤の効きづらい高コレステロール血症の治療 treatment of drug resistant hypercholesterolemia
English Journal
- The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.
- Pinzón-Daza M, Garzón R, Couraud P, Romero I, Weksler B, Ghigo D, Bosia A, Riganti C.SourceDepartment of Oncology, Faculty of Medicine, University of Turin, Turin, Italy Unidad de Bioquímica, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia Institut Cochin, Centre National de la Recherche Scientifique UMR 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U567, Université René Descartes, Paris, France Department of Biological Sciences, The Open University, Milton Keynes, UK Department of Medicine, Weill Medical College, New York, USA Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy.
- British journal of pharmacology.Br J Pharmacol.2012 Dec;167(7):1431-1447. doi: 10.1111/j.1476-5381.2012.02103.x.
- BACKGROUND AND PURPOSE The passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy in vivo, because it is extruded by P-glycoprotein
- PMID 22788770
- LDL Receptor-related Protein-1 is a sialic acid-independent receptor for myelin-associated glycoprotein (MAG) that functions in neurite outgrowth inhibition by MAG and CNS myelin.
- Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL.AbstractIn the injured adult mammalian CNS, products are generated that inhibit neuronal sprouting and regeneration. In recent years, most attention has focused on the myelin-associated inhibitory proteins (MAIs), Nogo-A, OMgp, and myelin-associated glycoprotein (MAG). Binding of MAIs to neuronal cell-surface receptors leads to activation of RhoA, growth cone collapse, and neurite outgrowth inhibition. Herein, we identify LDL receptor-related protein-1 (LRP1) as a high-affinity, endocytic receptor for MAG. In contrast with previously identified MAG receptors, binding of MAG to LRP1 occurs independently of terminal sialic acids. In primary neurons, functional inactivation of LRP1 with receptor-associated protein, depletion by RNAi knock-down, or LRP1 gene deletion is sufficient to significantly reverse MAG and myelin-mediated inhibition of neurite outgrowth. Similar results are observed when LRP1 is antagonized in PC12 and N2a cells. By contrast, inhibiting LRP1 does not attenuate inhibition of neurite outgrowth caused by chondroitin sulfate proteoglycans. Mechanistic studies in N2a cells showed that LRP1 and p75NTR associate in a MAG-dependent manner and that MAG mediated activation of RhoA may involve both LRP1 and p75NTR. LRP1 derivatives that include the complement-like repeat clusters, CII and CIV, bind MAG and other MAIs. When CII and CIV were expressed as Fc-fusion proteins, these proteins, purified full-length LRP1, and shed LRP1 all attenuated the inhibition of neurite outgrowth caused by MAG and CNS myelin in primary neurons. Collectively, our studies identify LRP1 as a novel MAG receptor that functions in neurite outgrowth inhibition.
- Journal of cell science.J Cell Sci.2012 Nov 6. [Epub ahead of print]
- In the injured adult mammalian CNS, products are generated that inhibit neuronal sprouting and regeneration. In recent years, most attention has focused on the myelin-associated inhibitory proteins (MAIs), Nogo-A, OMgp, and myelin-associated glycoprotein (MAG). Binding of MAIs to neuronal cell-surfa
- PMID 23132925
Japanese Journal
- Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor
- Moritou Yuki,Ikeda Fusao,Iwasaki Yoshiaki,Baba Nobuyuki,Takaguchi Kouichi,Senoh Tomonori,Nagano Takuya,Takeuchi Yasuto,Yasunaka Tetsuya,Ohnishi Hideki,Miyake Yasuhiro,Takaki Akinobu,Nouso Kazuhiro,Yamamoto Kazuhide
- Acta Medica Okayama 68(1), 17-22, 2014-02
- … The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. …
- NAID 120005372642
- Therapeutic Approaches to Vascular Protection in Ischemic Stroke
- Yamashita Toru,Abe Koji
- Acta Medica Okayama 65(4), 219-223, 2011-08
- … In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). … Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. …
- NAID 80021895203
- 神経筋接合部形成の分子機構 (特集 神経筋接合部--基礎から臨床まで)
- 樋口 理,山梨 裕司
- Brain and nerve 63(7), 649-655, 2011-07
- NAID 40018922071
Related Links
- Abstract The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that ...
- 1. PLoS One. 2013 Nov 29;8(11):e82026. doi: 10.1371/journal.pone.0082026. Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice. Basford JE, Koch S ...
Related Pictures
★リンクテーブル★
| リンク元 | 「LDL受容体関連タンパク質」「LDLレセプター関連タンパク質」 |
| 拡張検索 | 「LDL-receptor related protein 1」「LDL-receptor related protein 2」「LDL-receptor related protein-associated protein」 |
| 関連記事 | 「relate」「LDL」「LD」「L」「related protein」 |
「LDL受容体関連タンパク質」
- 英
- LDL-receptor related protein、LRP
- 関
- 低密度リ・タンパク質受容体関連タンパク質、LDLレセプター関連タンパク質
「LDLレセプター関連タンパク質」
LDL受容体関連タンパク質1、LDLレセプター関連タンパク質1
LDL受容体関連タンパク質2、LDLレセプター関連タンパク質2
- 関
- megalin
「relate」
- v.
- 関連する、関係する
- 関
- associate、association、attach、bearing、concern、connect、connection、correlate、correlation、germane、implicate、implication、interplay、link、pertain、pertinent、referable、reference、relation、relationship、relative、relevance、relevant、respect
「LDL」
- 同
- low density lipoprotein
- 関
- 低密度リポ蛋白、低密度リポタンパク、低密度リポタンパク質
- 関
- VLDLより由来し、これに含まれるTGがLPLにより分解されて比較的密度の高いLDLが生じる
- 60%コレステロール、5%トリグリセロール、主要なアポリポ蛋白はapoE
「LD」
- 学習障害 learning disability
- 背外側核 dorsolateral nucleus
- 連鎖不平衡 linkage disequilibrium
- 乳酸脱水素酵素 lactate dehydrogenase
「L」