L-selectin

同

CD62L

同

CD62L

WordNet

1. the 12th letter of the Roman alphabet (同)l

PrepTutorEJDIC

1. (最高・最適のものとして)…‘を'『選ぶ』,選抜する,選出する / (人が)『えり抜きの』,精選された / 《名詞の前にのみ用いて》(製品・産物などが)『品質の良い』,粒よりの,高級(上もの)の / (クラブなどが)人選のやかましい,閉鎖的な
2. lira(イタリアの貨幣単位リラ)
3. liter[s]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/04 14:53:17」(JST)

wiki en

[Wiki en表示]

Selectin L
Rendering based on PDB 1KJB.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LGF, 3CFW
Identifiers
Symbols	SELL; CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; TQ1
External IDs	OMIM: 153240 MGI: 98279 HomoloGene: 539 ChEMBL: 3161 GeneCards: SELL Gene
Gene Ontology Molecular function • protease binding • protein binding • heparin binding • carbohydrate binding • glycosphingolipid binding • cell adhesion molecule binding Cellular component • plasma membrane • integral to plasma membrane • external side of plasma membrane Biological process • cell adhesion • blood coagulation • response to ATP • regulation of immune response • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6402	20343
Ensembl	ENSG00000188404	ENSMUSG00000026581
UniProt	P14151	P18337
RefSeq (mRNA)	NM_000655	NM_001164059
RefSeq (protein)	NP_000646	NP_001157531
Location (UCSC)	Chr 1: 169.66 – 169.68 Mb	Chr 1: 164.06 – 164.08 Mb
PubMed search	[1]	[2]

L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes and the preimplantation embryo. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors that play important roles in lymphocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins.

Ligands

• GlyCAM-1, found in the high endothelial venules of the lymph nodes.
• CD34, found on endothelial cells.
• MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue.
• PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for lymphocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to lymphocytes expressing L-selectin, slowing lymphocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen.

High expression of L-selectin on human bone marrow progenitor cells is an early sign of cells becoming committed to lymphoid differentiation.

L-selectin is also present on the surface of human embryo trophoblasts prior to implantation into the uterus. Similar to its function in lymphocytes, L-selectin acts as a receptor to facilitate adhesion of the embryo to the site of invasion on the surface epithelium of the uterine endometrium. The embryo secretes human chorionic gonadotropin (hCG), which downregulates anti-adhesion factor, MUC-1, located on the uterine epithelium at the site of invasion. Removal of MUC-1 exposes the oligosaccharide ligands of the uterine epithelium, thus allowing binding by the L-selectin receptor of the trophopblast cell, followed by embryo adhesion and invasion.

References

External links

• L-Selectin at the US National Library of Medicine Medical Subject Headings (MeSH)
• Immunology at MCG 1/physresp

Further reading

• Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 (1): 33–7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831. 
• Nicholson IC (2003). "CD62L (L-selectin)". J. Biol. Regul. Homeost. Agents 16 (2): 144–6. PMID 12144128. 
• Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984. 
• Lasky LA, Singer MS, Dowbenko D et al. (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule". Cell 69 (6): 927–38. doi:10.1016/0092-8674(92)90612-G. PMID 1376638. 
• Ord DC, Ernst TJ, Zhou LJ et al. (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315. 
• Bevilacqua M, Butcher E, Furie B et al. (1991). "Selectins: a family of adhesion receptors". Cell 67 (2): 233. doi:10.1016/0092-8674(91)90174-W. PMID 1717161. 
• Tedder TF, Isaacs CM, Ernst TJ et al. (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins". J. Exp. Med. 170 (1): 123–33. doi:10.1084/jem.170.1.123. PMC 2189363. PMID 2473156. 
• Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor". Nature 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939. 
• Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor". J. Cell Biol. 109 (1): 421–7. doi:10.1083/jcb.109.1.421. PMC 2115458. PMID 2663882. 
• Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. doi:10.1073/pnas.86.14.5562. PMC 336895. PMID 2664786. 
• Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174. 
• Dianzani U, Bragardo M, Buonfiglio D et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Brenner B, Gulbins E, Schlottmann K et al. (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. doi:10.1073/pnas.93.26.15376. PMC 26412. PMID 8986819. 
• Zöllner O, Lenter MC, Blanks JE et al. (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin". J. Cell Biol. 136 (3): 707–16. doi:10.1083/jcb.136.3.707. PMC 2134294. PMID 9024699. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Prakobphol A, Thomsson KA, Hansson GC et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010. 
• Sassetti C, Tangemann K, Singer MS et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. Exp. Med. 187 (12): 1965–75. doi:10.1084/jem.187.12.1965. PMC 2212365. PMID 9625756. 
• Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin". Biochem. J. 341 (1): 61–9. doi:10.1042/0264-6021:3410061. PMC 1220330. PMID 10377245. 
• Bradley LM, Duncan DD,Tonkonogy S, Swain SL (1999). "CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma". J. Exp. Med. 174 (3): 547–59. doi:10.1084/jem.174.3.547. PMC 2118927. PMID 1678774. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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• 柏木 伸仁
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• … 3) The immunological self recognition mechanism of the host is reset, both non-self antigen stimulation by GMA carriers including β-1,4-glucan and self antigen stimulation of apoptotic granulocytes that are L-selectin deficient. …
• NAID 110008607576

• Altered Leukocyte Responsiveness in Dairy Cows with Naturally Occurring Chronic Staphylococcus aureus Mastitis

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• Journal of Veterinary Medical Science advpub(0), 1103040460, 2011
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• NAID 130000676901

Related Links

• セレクチン - 脂質と血栓の医学

... （GMP-140）のリガンドは、シアリルLe x 抗原（シアリルLewis x 糖鎖）であり、PSGL-1（P-selectin glycoprotein ligand-1）と 呼ばれるコア蛋白質（N末端付近のチロシン残基が、硫酸化されている）に結合している。 L-セレクチン ...

• L-Selectin - University of Virginia | Department of Biomedical ...

L-Selectin The smallest of the vascular selectins, a 74-100 kDa molecule, is constitutively expressed at the tips of microfolds on granulocytes, monocytes, and a vast array of circulating lymphocytes. L-selectin is also ...

Related Pictures

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★リンクテーブル★

リンク元	「白血球」「CD34」「L-セレクチン」「Lセレクチン」
関連記事	「select」「L」

「白血球」

　　[★]

英

leukocyte, leucocyte (Z), white blood cell (Z), WBC, white corpuscle, white cell

関

赤血球、血球、血液

白血球

• 顆粒球

• 好中球
• 好塩基球
• 好酸球

• 単球
• リンパ球

基準値

• 4000-9000 (/μl)　(2007前期解剖学授業プリント)

異常値の出るメカニズム第5版

• 5000- 8400 (/μl) (健常者の2/3)
• 4500-11000 (/μl) (95%範囲)

年齢との関連

• 新生児期>幼児期>成人期(20歳までに成人値)
• 妊婦でも増加(妊娠#妊娠による変化)

生理的な変動

• 精神的ストレス↑　　→　交感神経の刺激により好中球の血管壁遊離が促進されるため
• 午前↓、午後↑

基準値

			07解	異メ	流マ		HIM.A-1
顆粒球	好中球	桿状核球	40～70	44～66	40～60	4～14	0～5
		分葉核球				43～59	40～70
	好酸球		2～4	0～ 4	2～4		0～6
	好塩基球		0～2	0～0.5	0～2		0～2
無顆粒球	リンパ球		25～40	30～38	26～40		20～50
	単球		3～6	0～ 5	3～6		4～8

• 07解: 2007前期解剖学授業プリント
• 異メ: 異常値の出るメカニズム第5版 p.91
• 流マ: 流れが分かる実践検査マニュアル上巻 p.10

血管外滲出 extravasation (SMB.37 BPT.37)

(margination)

• 1. 赤血球は軽く早く流れるので血管の中央をながれ、白血球は血管のへりを流れている

(rolling)

• 2. IL-1, TNFで血管内皮細胞が活性化し、血管内腔にE-selectinを発現する
• 3. P-selectinはヒスタミンやトロンビンの働きにより、血管内腔に発現する
• 4. 白血球と血管内皮細胞の接着分子で接着することで、白血球がrollingを始める
• 3. 次第にselectinによる接着はdown regulateされる

(adheresion & arrested)

• 4. 炎症部位から出されたケモカインが血管内皮細胞の表面ののペプチドグリカンに結合し、白血球に提示される
• 5. 白血球表面のインテグリンが活性化し、血管内皮細胞のICAM-1, VCAM-1と強く結合する

(transmigration)

• 6. 白血球と血管内皮細胞に発現しているPECAM-1(CD31)がお互い接着し、白血球が血管内皮細胞の間隙を通って細胞外マトリックスに入る

血管内皮細胞		白血球
Rolling
E-selectin	－	糖鎖(SLex)
P-selectin	－	糖鎖
糖鎖(GlyCAM-1)(=CD34)	－	L-selectin
Adhestion
ICAM-1	－	LFA-1 integlin(CD11a/CD18), Mac-1 integlin(CD11b/CD18)
VCAM-1	－	VLA-1 integlin
transmigration
PECAM-1(CD31)	－	PECAM-1(CD31)

白血球の染色

• ギムザ染色

• 好酸性：赤く染まる→ヘモグロビン
• 好塩基性：青く染まる→リボソーム、核内のヒストン蛋白
• 好酸性でも好塩基性でもない：淡いピンクに染まる

• MPO myeloperoxidase反応（染色）

• MPOをもつ：顆粒球（前骨髄球～分葉核球）、単球（前単球～単球）
• MPOをもたない：リンパ球系細胞

• エステラーゼ esterase

• 好中球：長鎖エステルを分解
• 単球：短鎖エステルを分解

関節液

• 　　炎症 感染
• 200 2000 20000
• 500 5000 50000

臨床関連

• LAD(leukocyte adhesion deficiency)症候群 (SMB.37)

白血球のインテグリンが欠損または減少する先天性疾患

反復性の細菌皮膚感染

• 白血球減少症 leukopenia
• 白血球増加症 leukocytosis

• SIRSの診断基準：＜4,000/ul or ＞12,000/ul

「CD34」

　　[★]

同

MY10, SGP90

• 血液幹細胞の細胞マーカー

発現細胞

• hematopoietic precursors, capillary endothelium (IMM.785)
• GIST

• GISTではCD34とc-kit(CD117)が陽性

機能

• ligand for CD62L(L-selectin) (IMM.785)

「L-セレクチン」

　　[★]

英

L-selectin

同

MEL-14抗原 MEL-14 antigen、LAM-1、LECAM-1、LEC-CAM-1、Leu8、CD62L

関

セレクチンファミリー,細胞接着分子

「Lセレクチン」

　　[★]

英

L-selectin

関

L-セレクチン

「select」

　　[★]

• v.

• 選択する、選定する、選抜する、選ぶ

関

choice、choose、elect、elective、opt、option、optional、prefer、selection、selective、single

　

「L」

　　[★]

• リシジン
• リンキング数
• ロイシン
• free ligand concentration