Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/30 22:32:13」(JST)

wiki en

L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors that play important roles in lymphocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins.^[1]

Ligands

GlyCAM-1, found in the high endothelial venules of the lymph nodes.
CD34, found on endothelial cells.
MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue.
PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for lymphocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to lymphocytes expressing L-selectin, slowing lymphocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point^[2]. The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen.

References

^ "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402.
^ Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.

External links

L-Selectin at the US National Library of Medicine Medical Subject Headings (MeSH)
Immunology at MCG 1/physresp

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
2. 移植免疫 transplantation immunobiology
3. 非ステロイド性抗炎症剤（NSAIDs）：作用機序 nsaids mechanism of action
4. 非ステロイド性抗炎症剤（NSAIDs）：成人における治療使用および効果のばらつき nsaids therapeutic use and variability of response in adults
5. リンパ形質細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of lymphoplasmacytic lymphoma

English Journal

Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo.

Jeong YJ1, Kim JH1, Hong JM1, Kang JS1, Kim HR1, Lee WJ1, Hwang YI2.
Immunobiology.Immunobiology.2014 Jul;219(7):554-64. doi: 10.1016/j.imbio.2014.03.006. Epub 2014 Mar 20.
Vitamin C has been found to stimulate dendritic cells (DCs) to secrete more IL-12 and thereby drive naïve CD4(+) T cells to differentiate into Th1 cells. In the present study, we evaluated the effect of these vitamin C-treated DCs on CD8(+) T cell differentiation both in vitro and in vivo. Mouse bo
PMID 24698552

Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein.

Czerwińska ME1, Kiss AK1, Naruszewicz M2.
Food chemistry.Food Chem.2014 Jun 15;153:1-8. doi: 10.1016/j.foodchem.2013.12.019. Epub 2013 Dec 11.
Polyphenols, such as oleacein (3,4-DHPEA-EDA; 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde), are believed to play a role in the prevention of cardiovascular diseases. Due to an increase of neutrophil mediators in acute myocardial infarction the aim of this study was to establish the effect of
PMID 24491692

Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly.

Bulati M1, Buffa S1, Martorana A1, Candore G1, Lio D1, Caruso C1, Colonna-Romano G2.
Experimental gerontology.Exp Gerontol.2014 Jun;54:123-9. doi: 10.1016/j.exger.2013.12.011. Epub 2014 Jan 2.
The impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG(+)IgD(-)CD27(-), double negative, DN) population in the elderly, in which there is also a typical inflammatory micro-environment. In order to evaluate w
PMID 24389059

Japanese Journal

P1-013 NK細胞はIL-7と協調し腸炎惹起性T細胞の分化増殖を制御する

永石宇司,山地統,鬼沢道夫,鈴木雅博,谷口未樹,金井隆典,荒瀬尚,渡辺守
日本臨床免疫学会会誌 35(4), 333a-333a, 2012
… 対する細胞傷害活性はIL-7の有無によって影響されなかった．抗asialo GM1抗体の投与でRAG−/−のNK細胞を除去し，naive T細胞の移入後早期の腸間膜リンパ節を解析した結果，移入5日後よりCD44+ CD62L−およびCD44− CD62L−のT細胞分画が増加した．RAG−/−およびIL-7−/−RAG−/−へnaive T細胞を移入して大腸炎を誘発しつつ，抗asialo GM1抗体を第1-4週，第5-12週，第1-12週に投与した各群と12週間の溶媒コントロー …
NAID 130003364050

P1-009 Abatacept治療によるリウマチ患者末梢血Treg phenotypeおよびTreg/Th17バランスの変化

前田伸治,前田智代,難波大夫,速水芳仁
日本臨床免疫学会会誌 35(4), 331a-331a, 2012
… 【方法】今回我々はAbatacept使用前後（0, 4 wks）のヒトリウマチ患者末梢血（n=16) CD4+ Foxp3+T cell (Treg）のPhenotype (CD25, CD45RA, CD69, CD62L, CD31, CD39, CD127, CD161），機能マーカー（CTLA-4 (intra), GITR, GARP, LAG-3, HLA-DR）ケモカイン受容体（CCR4, CCR6, CXCR3）および，内在性（Helios）および増殖マーカー（Ki67）と全部で18のマーカーを染色，多色フローサイトメトリー法にて網羅的に比較解析した． …
NAID 130003364046

W6-6 関節リウマチにおけるCTLA4-Ig共刺激シグナル阻害剤のCD8+ T細胞への影響

松谷隆治,李穎,村上美帆,關口昌弘,松井聖,北野将康,大村浩一郎,井村嘉孝,藤井隆夫,黒岩孝則,中原英子,前田恵治,船内正憲,村上孝作,入交重雄,森田智視,川人豊,三森経世,佐野統,西本憲弘
日本臨床免疫学会会誌 35(4), 313b-313b, 2012
… 【方法】生物学的製剤未使用RA患者に対するABTの有効性と安全性の検討試験（ABROAD試験）に登録した31例の患者から治療前および治療後6ヵ月に末梢血単核球を分離し，T細胞活性化に関わるCD25, CD69, CD62L等の細胞表面マーカーをFACSで解析し，CD4+ T細胞とCD8+ T細胞の間で比較した． …
NAID 130003364018

Related Pictures

★リンクテーブル★

リンク元	「CD34」「naive CD4 T cell」「L-セレクチン」「L-selectin」

「CD34」

Selectin L
	; Rendering based on PDB 1KJB.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2LGF, 3CFW
Identifiers
Symbols	SELL; CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; TQ1
External IDs	OMIM: 153240 MGI: 98279 HomoloGene: 539 ChEMBL: 3161 GeneCards: SELL Gene
Gene Ontology
Molecular function	• protease binding; • protein binding; • heparin binding; • carbohydrate binding; • glycosphingolipid binding; • cell adhesion molecule binding;
Cellular component	• plasma membrane; • integral to plasma membrane; • external side of plasma membrane;
Biological process	• cell adhesion; • blood coagulation; • response to ATP; • regulation of immune response; • leukocyte migration;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;