JNK mitogen-activated protein kinase

出典: meddic

MAPキナーゼJNK、c-Jun N末端キナーゼ

c-Jun N-terminal kinase、c-Jun NH2-terminal kinase、JNK

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases.
  • Engstrom A1, Wang H2, Xia Z3.
  • Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2015 Aug;29(5):1146-55. doi: 10.1016/j.tiv.2015.05.001. Epub 2015 May 9.
  • Adult hippocampal neurogenesis is the process whereby adult neural precursor cells (aNPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG) generate adult-born, functional neurons in the hippocampus. This process is modulated by various extracellular and intracellular stimuli, and the adult-b
  • PMID 25967738
  • Topiramate protects against glutamate excitotoxicity via activating BDNF/TrkB-dependent ERK pathway in rodent hippocampal neurons.
  • Mao XY1, Cao YG2, Ji Z3, Zhou HH1, Liu ZQ4, Sun HL5.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Jul 3;60:11-7. doi: 10.1016/j.pnpbp.2015.01.015. Epub 2015 Feb 7.
  • Topiramate (TPM) was previously found to have neuroprotection against neuronal injury in epileptic and ischemic models. However, whether TPM protects against glutamate-induced excitotoxicity in hippocampal neurons is elusive. Our present work aimed to evaluate the protective effect of TPM against gl
  • PMID 25661849
  • miR-1470 mediates lapatinib induced p27 upregulation by targeting c-jun.
  • Nie W1, Song W, Zhang W, Wang Y, Zhu A, Shao J, Guan X.
  • Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1630-9. doi: 10.1002/jcp.24910.
  • Our previous study indicated that lapatinib induces p27-dependent G(1) arrest through both transcriptional and post-translational mechanisms. Using miRNA microarray technology and quantitative RT-PCR, we further investigated the potential miRNAs that involved in p27 upregulation and Her-2 signaling
  • PMID 25545366


  • Irciniastatin A Induces Potent and Sustained Activation of Extracellular Signal-Regulated Kinase and Thereby Promotes Ectodomain Shedding of Tumor Necrosis Factor Receptor 1 in Human Lung Carcinoma A549 Cells
  • 3β-Angeloyloxy-8β,10β-dihydroxyeremophila-7(11)-en-12,8α-lactone Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Cells
  • Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice


JNK-activated kinase 1, JNK-activating kinase 1, MAP kinase kinase 4, MAPK/ERK kinase 4, MAPKK 4, MEK 4 ...
Mitogen-activated protein kinase 8 (EC: Short name: MAP kinase 8 Short name: MAPK 8 Alternative name(s): JNK-46 Stress-activated protein kinase 1c Short name: SAPK1c Stress-activated protein kinase JNK1 c-Jun ...



リンク元c-Jun N-terminal kinase」「MAPキナーゼJNK

c-Jun N-terminal kinase」


c-Jun N末端キナーゼ

c-Jun NH2-terminal kinase、JNKJNK mitogen-activated protein kinase



JNK mitogen-activated protein kinase
c-Jun N末端キナーゼ



  • v.
  • 活性化する、賦活化する、賦活する
activatedactivationturn on

WordNet   license wordnet

「aerate (sewage) so as to favor the growth of organisms that decompose organic matter」

WordNet   license wordnet

「make (substances) radioactive」

WordNet   license wordnet

「make active or more active; "activate an old file"」

WordNet   license wordnet

「make more adsorptive; "activate a metal"」

PrepTutorEJDIC   license prepejdic

「…'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する」



  • adj.
  • 活性化の、活性化型の、賦活化の
activateactivated formactivationturn on

WordNet   license wordnet

「rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive」

WordNet   license wordnet

「(of e.g. a molecule) made reactive or more reactive」

WordNet   license wordnet

「(military) set up and placed on active assignment; "a newly activated unit"」

WordNet   license wordnet

「(of sewage) treated with aeration and bacteria to aid decomposition」


  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic




c-Jun N-terminal kinase, c-Jun NH2-terminal kinase, JNK mitogen-activated protein kinase
  • MAPKファミリーの一つ。JNK1/2/3がある。
  • JNK1:全身組織に発現
  • JNK2:全身組織に発現
  • JNK3:脳に限局




WordNet   license wordnet

「the 10th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic