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make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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蛋白(たんばく)質

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/30 23:12:15」(JST)

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Growth factor receptor-bound protein 7, also known as GRB7, is a protein which in humans is encoded by the GRB7 gene.^[1]^[2]

Function

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.^[1]

Clinical significance

GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in migration^{[citation needed]}, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.

Interactions

GRB7 has been shown to interact with Insulin receptor,^[3] PTK2,^[4] RET proto-oncogene,^[5] Rnd1^[6] and EPH receptor B1.^[7]

References

^ ^a ^b "Entrez Gene: GRB7 growth factor receptor-bound protein 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886.
^ Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (August 1998). "A novel variant of human Grb7 is associated with invasive esophageal carcinoma". J. Clin. Invest. 102 (4): 821–7. doi:10.1172/JCI2921. PMC 508945. PMID 9710451. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=508945.
^ Kasus-Jacobi, A; Béréziat V, Perdereau D, Girard J, Burnol A F (Apr. 2000). "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2". Oncogene (ENGLAND) 19 (16): 2052–9. doi:10.1038/sj.onc.1203469. ISSN 0950-9232. PMID 10803466.
^ Han, D C; Guan J L (Aug. 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". J. Biol. Chem. (UNITED STATES) 274 (34): 24425–30. doi:10.1074/jbc.274.34.24425. ISSN 0021-9258. PMID 10446223.
^ Pandey, A; Liu X, Dixon J E, Di Fiore P P, Dixit V M (May. 1996). "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". J. Biol. Chem. (UNITED STATES) 271 (18): 10607–10. doi:10.1074/jbc.271.18.10607. ISSN 0021-9258. PMID 8631863.
^ Vayssière, B; Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner K M, Chardin P, Camonis J (Feb. 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. (NETHERLANDS) 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. ISSN 0014-5793. PMID 10664463.
^ Han, Dong Cho; Shen Tang-Long, Miao Hui, Wang Bingcheng, Guan Jun-Lin (Nov. 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. (United States) 277 (47): 45655–61. doi:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469.

External links

MeSH GRB7+Adaptor+Protein

UpToDate Contents

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English Journal

Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines.

van Agthoven T, Godinho MF, Wulfkuhle JD, Petricoin EF 3rd, Dorssers LC.SourceDepartment of Pathology, Josephine Nefkens Institute, Erasmus MC-University Medical Center Rotterdam, The Netherlands. a.vanagthoven@erasmusmc.nl
International journal of cancer. Journal international du cancer.Int J Cancer.2012 Nov 1;131(9):1998-2007. doi: 10.1002/ijc.27489. Epub 2012 Mar 20.
Previously, we have identified a panel of breast cancer antiestrogen resistance (BCAR) genes. Several of these genes have clinical relevance because mRNA or protein levels associate with tamoxifen resistance or tumor aggressiveness. We postulated that changes in activation status of protein signalin
PMID 22328489

The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression.

Balogh K, Asa SL, Zheng L, Cassol C, Cheng S, Ezzat S.SourceDepartment of Medicine, University Health Network, Toronto, Ontario, Canada.
Oncogene.Oncogene.2012 Sep 6;31(36):4012-21. doi: 10.1038/onc.2011.569. Epub 2011 Dec 12.
The growth factor receptor-bound protein (Grb) 14 is an adaptor molecule of the Grb7/10/14 family with characteristic Between Plekstrin and SH2 (BPS) domains serving to avidly bind tyrosine kinases. Grb14 inhibits insulin receptor (IR) catalytic activity through interaction with the BPS domain and i
PMID 22158039

★リンクテーブル★

リンク元	「Grb7タンパク質」「増殖因子受容体結合タンパク質7」
関連記事	「adapt」「adaptor protein」「adaptor」

「Grb7タンパク質」

Growth factor receptor-bound protein 7
	; PDB rendering based on 1mw4.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1MW4, 1WGR, 2L4K, 2QMS, 3PQZ
Identifiers
Symbols	GRB7; ;
External IDs	OMIM: 601522 MGI: 102683 HomoloGene: 3881 GeneCards: GRB7 Gene
Gene Ontology
Molecular function	• RNA binding; • SH3/SH2 adaptor activity; • protein binding; • lipid binding; • protein kinase binding; • phosphatidylinositol binding; • identical protein binding;
Cellular component	• cytoplasm; • cytosol; • cytosol; • plasma membrane; • focal adhesion; • cytoplasmic stress granule; • cell junction; • cell projection;
Biological process	• signal transduction; • epidermal growth factor receptor signaling pathway; • blood coagulation; • negative regulation of translation; • positive regulation of cell migration; • stress granule assembly; • leukocyte migration;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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