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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/03/27 21:28:57」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/10 05:16:53」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/01/18 09:10:57」(JST)

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  • Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes.
  • Delic S, Lottmann N, Jetschke K, Reifenberger G, Riemenschneider MJ.SourceDepartment of Neuropathology, Heinrich-Heine-University, Düsseldorf Department of Neuropathology, Regensburg University Hospital, Regensburg Department of Neurosurgery (Knappschaftskrankenhaus), Ruhr-University, Bochum, Germany.
  • Neuropathology and applied neurobiology.Neuropathol Appl Neurobiol.2012 Apr;38(2):201-12. doi: 10.1111/j.1365-2990.2011.01207.x.
  • S. Delic, N. Lottmann, K. Jetschke, G. Reifenberger and M. J. Riemenschneider (2012) Neuropathology and Applied Neurobiology38, 201-212 Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes Aims: The molecular mechanisms underlying th
  • PMID 21722156
  • Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.
  • Lan T, Chen Y, Sang J, Wu Y, Wang Y, Jiang L, Tao Y.SourceSchool of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
  • Oncology reports.Oncol Rep.2012 Mar 15. doi: 10.3892/or.2012.1726. [Epub ahead of print]
  • Our previous research data showed that type II cGMP-dependent protein kinase (PKGII) inhibited EGF-induced MAPK/ERK-mediated signal transduction through blocking the phosphorylation of EGFR caused by EGF. Since EGFR also mediates other MAPK-mediated signal transd
  • PMID 22427012
  • Multivalent binding and facilitated diffusion account for the formation of the grb2-sos1 signaling complex in a cooperative manner.
  • McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.SourceDepartment of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami , Miami, Florida 33136, United States.
  • Biochemistry.Biochemistry.2012 Mar 13;51(10):2122-35. Epub 2012 Mar 2.
  • Despite its key role in driving cellular growth and proliferation through receptor tyrosine kinase (RTK) signaling, the Grb2-Sos1 macromolecular interaction remains poorly understood in mechanistic terms. Herein, using an array of biophysical methods, we provide evidence that although the Grb2 adapt
  • PMID 22360309
  • Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
  • Serra-Nédélec Ade R, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A.SourceInstitut National de la Santé et de la Recherche Médicale U1048 and Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires, F-31432 Toulouse, France.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Mar 13;109(11):4257-62. Epub 2012 Feb 27.
  • Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by congenital cardiopathies, facial dysmorphic features, and short stature. How mutated SHP2 induces growth retardation remains poorly understood. We re
  • PMID 22371576


  • 急性肝不全の病態形成におけるGab1の意義 (特集 急性肝不全の病態と治療)
  • 古田 訓丸,吉田 雄一,竹原 徹郎
  • 消化器内科 59(4), 392-399, 2014-10
  • NAID 40020244484
  • Non-Markovian properties and multiscale hidden Markovian network buried in single molecule time series
  • Sultana Tahmina,Takagi Hiroaki,Morimatsu Miki,Teramoto Hiroshi,Li Chun-Biu,Sako Yasushi,Komatsuzaki Tamiki
  • Journal of chemical physics 139(24), 245101-1-245101-12, 2013-12-28
  • … To demonstrate the potential of our scheme, we investigated single-molecule time series of dissociation and association kinetics between epidermal growth factor receptor (EGFR) on the plasma membrane and its adaptor protein Ash/Grb2 (Grb2) in an in vitro reconstituted system. … It is also found that visiting the unbound form of the EGFR-Grb2 system approximately resets all information of history or memory of the process. …
  • NAID 120005385318
  • Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR
  • Ogura Kenji,Okamura Hideyasu
  • Scientific reports 3, 2013-10-09
  • … Growth factor receptor-bound protein 2 (Grb2) is a small adapter protein composed of a single SH2 domain flanked by two SH3 domains. … The N-terminal SH3 (nSH3) domain of Grb2 binds a proline-rich region present in the guanine nucleotide releasing factor, son of sevenless (Sos). … Using NMR relaxation dispersion and chemical shift analysis methods, we investigated the conformational change of the Sos-derived proline-rich peptide during the transition between the free and Grb2 nSH3-bound states. …
  • NAID 120005348191


Function and expression Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various ...
「アダプター蛋白質Grb2の柔軟な構造と機能」 北海道大学大学院薬学研究科 湯沢聡 Grb2は細胞膜に存在するさまざまな成長因子受容体とRas/MAPKカスケードとの間を仲介する蛋白質であり、進化的にも保存されている。Grb2は酵素 ...






receptor tyrosine kinase receptor, tyrosine kinase RTK


  • リガンド結合→レセプターの二量体化→レセプターの細胞膜内領域を自己リン酸化

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