クロンカイト・カナダ症候群
WordNet
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
- a nation in northern North America; the French were the first Europeans to settle in mainland Canada; "the border between the United States and Canada is the longest unguarded border in the world"
PrepTutorEJDIC
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
- 『カナダ』(北米大陸の北部,英連邦独立国;首都は Ottawa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/21 20:12:58」(JST)
[Wiki en表示]
| Cronkhite–Canada syndrome |
| Classification and external resources |
| ICD-10 |
K63.8, K63.5, K31.7 |
| ICD-9-CM |
211.3 |
| OMIM |
175500 |
| DiseasesDB |
1924 |
| eMedicine |
derm/729 |
| MeSH |
D044483 |
Cronkhite–Canada syndrome is a rare syndrome characterized by multiple polyps of the digestive tract. It is sporadic (i.e. it does not seem to be a hereditary disease),[1] and it is currently considered acquired[2] and idiopathic (i.e. cause remains unknown).
About two-thirds of patients are of Japanese descent and the male to female ratio is 2:1.
It was characterized in 1955.[3][4]
Contents
- 1 Presentation
- 2 Cause
- 3 Treatment
- 4 References
- 5 External links
Presentation
Polyps are most frequent in the stomach and large intestine, are also found in the small intestine, and are least frequent in the esophagus. A biopsy will reveal them to be hamartomas; the possibility that they progress to cancer is generally considered to be low,[5] although it has been reported multiple times in the past. Chronic diarrhea and protein-losing enteropathy are often observed. Possible collateral features include variable anomalies of ectodermal tissues, such as alopecia, atrophy of the nails, or skin pigmentation
Cause
The cause of the disease is unknown. It was originally thought that the epidermal changes were secondary to profound malnutrition as a result of protein-losing enteropathy. Recent findings have called this hypothesis into question; specifically, the hair and nail changes may not improve with improved nutrition.
Other conditions consisting of multiple hamartomatous polyps of the digestive tract include Peutz-Jeghers syndrome, juvenile polyposis, and Cowden disease. Related polyposis conditions are familial adenomatous polyposis, attenuated familial adenomatous polyposis, Birt–Hogg–Dubé syndrome and MUTYH.
Treatment
Treatments proposed include cromolyn sodium and prednisone.[6]
References
- ^ Vernia P, Marcheggiano A, Marinaro V, Morabito S, Guzzo I, Pierucci A (October 2005). "Is Cronkhite-Canada Syndrome necessarily a late-onset disease?". Eur J Gastroenterol Hepatol 17 (10): 1139–41. doi:10.1097/00042737-200510000-00022. PMID 16148564.
- ^ Calva D, Howe JR (August 2008). "Hamartomatous polyposis syndromes". The Surgical clinics of North America 88 (4): 779–817, vii. doi:10.1016/j.suc.2008.05.002. PMC 2659506. PMID 18672141.
- ^ Cronkhite LW, Canada WJ (June 1955). "Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia". N. Engl. J. Med. 252 (24): 1011–5. doi:10.1056/NEJM195506162522401. PMID 14383952.
- ^ Junnarkar SP, Sloan JM, Johnston BT, Laird JD, Irwin ST (May 2001). "Cronkhite-Canada syndrome". The Ulster medical journal 70 (1): 56–8. PMC 2449205. PMID 11428328.
- ^ Nagata J, Kijima H, Hasumi K, Suzuki T, Shirai T, Mine T (June 2003). "Adenocarcinoma and multiple adenomas of the large intestine, associated with Cronkhite-Canada syndrome". Dig Liver Dis 35 (6): 434–8. doi:10.1016/s1590-8658(03)00160-9. PMID 12868681.
- ^ Ward E, Wolfsen HC, Ng C (February 2002). "Medical management of Cronkhite-Canada syndrome". South. Med. J. 95 (2): 272–4. doi:10.1097/00007611-200202000-00025. PMID 11846261.
External links
- "Cronkite-Canada syndrome".
|
Digestive system neoplasia (C15–C26/D12–D13, 150–159/211)
|
|
| GI tract |
| Upper |
| Esophagus |
- Squamous cell carcinoma
- Adenocarcinoma
|
|
| Stomach |
- Gastric carcinoma
- Signet ring cell carcinoma
- Gastric lymphoma
- Linitis plastica
|
|
|
| Lower |
| Small intestine |
|
|
| Appendix |
- Carcinoid
- Pseudomyxoma peritonei
|
|
| Colon/rectum |
- colorectal polyp: Peutz–Jeghers syndrome
- Juvenile polyposis syndrome
- Familial adenomatous polyposis/Gardner's syndrome
- Cronkhite–Canada syndrome
- neoplasm: Adenocarcinoma
- Familial adenomatous polyposis
- Hereditary nonpolyposis colorectal cancer
|
|
| Anus |
|
|
|
| Upper and/or lower |
- Gastrointestinal stromal tumor
- Krukenberg tumor (metastatic)
|
|
|
| Accessory |
| Liver |
- malignant: Hepatocellular carcinoma
- Hepatoblastoma
- benign: Hepatocellular adenoma
- Cavernous hemangioma
- hyperplasia: Focal nodular hyperplasia
- Nodular regenerative hyperplasia
|
|
| Biliary tract |
- bile duct: Cholangiocarcinoma
- Klatskin tumor
- gallbladder: Gallbladder cancer
|
|
| Pancreas |
- exocrine pancreas: Adenocarcinoma
- Pancreatic ductal carcinoma
- cystic neoplasms: Serous microcystic adenoma
- Intraductal papillary mucinous neoplasm
- Mucinous cystic neoplasm
- Solid pseudopapillary neoplasm
|
|
|
| Peritoneum |
- Primary peritoneal carcinoma
- Peritoneal mesothelioma
- Desmoplastic small round cell tumor
|
|
|
Index of digestion
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
|
|
|
UpToDate Contents
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English Journal
- Genetic alterations in sporadic and hereditary colorectal cancer: implementations for screening and follow-up.
- Souglakos J.SourceDepartment of Medical Oncology, University General Hospital of Heraklion, Heraklion, Greece. johnsougl@gmail.com
- Digestive diseases (Basel, Switzerland)." abstractLink="yes" alsec="jour" alterm="Dig Dis.2007;25(1):9-19.
- The genetics underlying an inherited predisposition to cancer are rapidly being uncovered. This fact may ultimately lead to the routine use of molecular tools to diagnose these disorders, and establish interventions to prevent the development of cancer. Among the multiple cancer family syndromes, se
- PMID 17384504
- [Cronkite-Canada-syndrome].
- Zeitschrift fur Gastroenterologie." abstractLink="yes" alsec="jour" alterm="Z Gastroenterol.1974 Dec;12(8):609-10.
- PMID 4440060
Related Links
- 11 Jan 2010 ... Cronkhite-Canada syndrome (CCS) is a rare nonfamilial syndrome characterized by marked epithelial disturbances in the GI tract and epidermis.
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