WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

carbonの化学記号
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/24 06:25:47」(JST)

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Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.^[1]

The IL-2 receptor common gamma chain (also known as CD132) is shared between:
- IL-2 receptor
- IL-4 receptor
- IL-7 receptor
- IL-9 receptor
- IL-13 receptor
- IL-15 receptor^[2]
The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
- GM-CSF receptor
- IL-3 receptor
- IL-5 receptor.^[3]
The gp130 receptor ([Glycoprotein 130]) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
- IL-6 receptor
- IL-11 receptor
- IL-12 receptor
- IL-27 receptor
- Leukemia inhibitory factor receptor
- Oncostatin M receptor

Examples

Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Interleukin receptors

Interleukin-2 receptor
Interleukin-3 receptor
Interleukin-4 receptor
Interleukin-5 receptor
Interleukin-6 receptor
Interleukin-7 receptor
Interleukin-9 receptor
Interleukin-11 receptor
Interleukin-12 receptor
Interleukin-13 receptor
Interleukin-15 receptor
Interleukin-21 receptor
Interleukin-23 receptor
Interleukin-27 receptor

Colony stimulating factor receptors

Erythropoietin receptor
GM-CSF receptor
G-CSF receptor

Hormone receptor/neuropeptide receptor

Growth hormone receptor
Prolactin receptor
Leptin receptor^[4]

Other

Oncostatin M receptor
Leukemia inhibitory factor receptor

References

^ Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
^ He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
^ Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi:10.1074/jbc.273.2.1192. PMID 9422786.
^ Cirillo, Donatella; Rachiglio, Anna Maria; la Montagna, Raffaele; Giordano, Antonio; Normanno, Nicola (1 November 2008). "Leptin signaling in breast cancer: An overview". Journal of Cellular Biochemistry. 105 (4): 956–964. doi:10.1002/jcb.21911.

External links

Cytokine Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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Related Pictures

★リンクテーブル★

リンク元	「コロニー刺激因子受容体」「colony-stimulating factor receptor」「CSFR」「CSF受容体」
拡張検索	「GM-CSF receptor」「G-CSF receptor」「M-CSF receptor」
関連記事	「CS」「C」「CSF」