発現細胞

T細胞サブセット、B細胞サブセット、単球、マクロファージ

分子量

180

機能

isoform of CD45 containing the A, B, and C exons

ファミリー

fibronectin type II

発現の強度

記憶T細胞では強く発現するので、マーカーとして使われる。

	naive T cell	effector T cell	memory T cell
CD45RO	＋	＋＋＋	＋＋＋
CD45RA	＋	＋＋＋	＋＋＋

UpToDate Contents

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1. 適応細胞性免疫応答 the adaptive cellular immune response
2. T細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell prolymphocytic leukemia
3. 移植片対宿主病の病因 pathogenesis of graft versus host disease
4. 関節リウマチのT細胞標的療法 t cell targeted therapies for rheumatoid arthritis
5. 特発性CD4陽性リンパ球減少症 idiopathic cd4 lymphocytopenia

English Journal

Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation.

Casas C, Paul C, Lahfa M, Livideanu B, Lejeune O, Alvarez-Georges S, Saint-Martory C, Degouy A, Mengeaud V, Ginisty H, Durbise E, Schmitt AM, Redoulès D.SourcePôle Recherche, Exploration, Développement Clinique et Vigilances, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Experimental dermatology.Exp Dermatol.2012 Dec;21(12):906-10. doi: 10.1111/exd.12030.
The aim of this study is to quantify D. folliculorum colonisation in rosacea subtypes and age-matched controls and to determine the relationship between D. folliculorum load, rosacea subtype and skin innate immune system activation markers. We set up a multicentre, cross-sectional, prospective stu
PMID 23171449

Sialic acid cyclization of human Th homing receptor glycan associated with recurrent exacerbations of atopic dermatitis.

Sakuma K, Furuhashi T, Kondo S, Yabe U, Ohmori K, Ito H, Aoki M, Morita A, Kannagi R.SourceDivision of Molecular Pathology, Aichi Cancer Center, Nagoya, Aichi 464-8681, Japan.
Journal of dermatological science.J Dermatol Sci.2012 Dec;68(3):187-93. doi: 10.1016/j.jdermsci.2012.09.015. Epub 2012 Oct 8.
BACKGROUND: The molecular pathogenesis underlying recurrent exacerbations of atopic dermatitis (AD) is unclear. Some peripheral CCR4(+) and CCR7(+) helper memory T cells express the specific homing receptor, sialyl 6-sulfo Lewis X (G152 glycan). This glycan loses receptor activity via cyclization of
PMID 23088960

Systemic varicella zoster virus reactive effector memory T-cells impaired in the elderly and in kidney transplant recipients.

van Besouw NM, Verjans GM, Zuijderwijk JM, Litjens NH, Osterhaus AD, Weimar W.SourceDepartment of Internal Medicine-Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. n.vanbesouw@erasmusmc.nl.
Journal of medical virology.J Med Virol.2012 Dec;84(12):2018-25. doi: 10.1002/jmv.23427.
Varicella zoster virus (VZV) infections cause varicella and subsequently herpes zoster upon reactivation. Immune-compromised individuals and the elderly are at high risk of developing herpes zoster due to waning of VZV-specific T-cell immunity. In the present study, a novel functional T-cell assay w
PMID 23080511

Japanese Journal

Blastic Plasmacytoid Dendritic Cell Neoplasm：芽球性形質細胞様樹状細胞腫瘍の 2 例

白瀬春奈,山口さやか,平良清人 [他],林健太郎,苅谷嘉之,山本雄一,高橋健造,上里博
西日本皮膚科 76(6), 577-582, 2014
… 病理組織学的所見では真皮全層に異型単核球細胞がびまん性に浸潤し，この細胞は CD4・CD7・CD56・CD123・TCL-1 が陽性，CD20・CD45RO・EBER はいずれも陰性であり，blastic plasmacytoid dendritic cell neoplasm と診断した。 …
NAID 130005065017

アトピー性皮膚炎に合併した未分化大細胞リンパ腫の 1 例

金丸志保,天野正宏,井上知宏,石井千寸,室井栄治,成田博実,瀬戸山充
西日本皮膚科 76(2), 109-114, 2014
… 免疫組織化学的に腫瘍細胞は CD3，CD4，CD30，CD45RO が陽性，CD8，CD20，ALK は陰性，サザンブロット法で TCR-Cb1の再構成を認め，PET-CT やリンパ節生検でリンパ節や内臓への浸潤を認めないため，AD に合併した原発性皮膚未分化大細胞リンパ腫 (primary cutaneous anaplastic large cell lymphoma ： PCALCL9 と診断した。 …
NAID 130004831870

肛門病変内にAIDS関連悪性リンパ腫を認めた1例

松田博光,壬生隆一,豊永敬之,園田幸生,清永英利,冨永洋平,平田敬治
日本大腸肛門病学会雑誌 67(4), 263-267, 2014
症例は30歳代の男性で，前医にて未分化大細胞リンパ腫（ALCL：Ann Arbor分類IV期，B症状あり，PS4，AIDS発症）と診断され，化学療法と多剤併用療法（highly active anti-retroviral therapy）を受けていた．化学療法中の血球減少時に肛門周囲膿瘍・痔廔を発症したため，治療目的にて当院へ紹介された．初診時，肛門周囲7時方向に皮下膿瘍を触れ，肛門管内には見張 …
NAID 130003394589

Immunohistochemical investigation of the coma blister and its pathogenesis

, , , , , , , ,
The Journal of Medical Investigation 60(3.4), 256-261, 2013
… Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. … Degenerated sweat glands featured CD45RO and M30 immunoreactivity. … Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. …
NAID 130004822691

Related Pictures

CD45RO Antibody Anti-CD45RO - UCHL1 Human CD45RO Antibody PE UCHL1 RUO Human CD45RO Antibody FITC UCHL1 RUO Effector Memory t Cells Ccr7 Naive And CD45RO Human CD45RO Antibody PE-Cyanine7 UCHL1

★リンクテーブル★

リンク元	「CD22」「CD45RA」「記憶T細胞」
関連記事	「CD45」「CD45R」

「CD22」

　　[★]

同: B5,Leucine-14, sialic acid-binding Ig superfamily lectin-2
関: CD

発現細胞

成熟B細胞

分子量

α:130, β:140

機能

Binds sialoconjugates
CD22 is an adhesion molecule and prossesses lectin activity mediated by the first N-terminal Ig-like domain.(WCH.36)
CD22 binds to CD45RO and CDw75.(WCH.36)
CD22-deficident mice develop hight tires of high-affinity autoantibodies.(WCH.36)
CD22 is "masked" on resting B cells, unavailable for binding to its normal ligands. Release from this "masking" is necessary for CD22 to bind to its sialic acid ligands and exert the negative regulatory function on B-cell activation.(WCH.36)
免疫反応の抑制に関与している(IMM.244,631)