WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

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An ELISA assay with two monoclonal antibodies allows the estimation of free factor H and identifies patients with acquired deficiency of this complement regulator.

Nozal P1, Garrido S1, Alba-Domínguez M2, Espinosa L3, Peña A3, Córdoba SR4, Sánchez-Corral P5, López-Trascasa M6.
Molecular immunology.Mol Immunol.2014 Apr;58(2):194-200. doi: 10.1016/j.molimm.2013.11.021. Epub 2013 Dec 28.
Complement factor H (FH) serum levels can be affected by the presence of immune complexes of FH with autoantibodies like in autoimmune forms of atypical haemolytic uraemic syndrome (aHUS) or with C3b in homozygous factor I (FI) deficiency. These complexes reduce the amount of free functional circula
PMID 24378252

Skerka C1, Chen Q, Fremeaux-Bacchi V, Roumenina LT.
Molecular immunology.Mol Immunol.2013 Dec 15;56(3):170-80. doi: 10.1016/j.molimm.2013.06.001. Epub 2013 Jul 3.
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a numbe
PMID 23830046

Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis.

Haerynck F1, Stordeur P, Vandewalle J, Van Coster R, Bordon V, De Baets F, Schelstraete P, Javaux C, Bouvry MR, Fremeaux-Bacchi V, Dehoorne J.
Journal of clinical immunology.J Clin Immunol.2013 Nov;33(8):1293-301. doi: 10.1007/s10875-013-9944-8. Epub 2013 Oct 20.
PURPOSE: Complement regulators control the activated complement system. Defects in this homeostasis can result in tissue damage and autoimmune diseases with a heterogeneity in clinical presentation. Complement factor I (FI), a serine protease, is an important regulator of alternative pathway activat
PMID 24142231

リンク元	「I因子欠損症」「C3b不活性化因子欠損症」
関連記事	「deficiency」「C3b」「C3」「C」「inactivator」

関: absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve

古典的経路：C3からC4b2aのもつC3 convatase活性により生成し、C4b2a3bはC5 convertase活性を持つ (2008前期免疫学プリント 68)
別経路：C3からC3bBbPのもつC3 convertase活性により生成し、n(C3bBb)はC5 convertase活性を持つ (2008前期免疫学プリント 68)
別経路では細菌の表面でC3bが安定的に存在→オプソニン作用を有する