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- 1. 家族性地中海熱の病態生理 pathophysiology of familial mediterranean fever
- 2. ツタウルシ（トキシコデンドロン属）による皮膚炎 poison ivy toxicodendron dermatitis
- 3. ヘパリンおよび低分子ヘパリンの治療使用 therapeutic use of heparin and low molecular weight heparin
- 4. 非ST上昇型急性冠症候群における抗凝固療法 anticoagulant therapy in non st elevation acute coronary syndromes
- 5. ST上昇型心筋梗塞における抗凝固療法 anticoagulant therapy in acute st elevation myocardial infarction
English Journal
- Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes.
- Matsunaga N1, Kaneko N1, Staub AY1, Nakanishi T1, Nunoya K1, Imawaka H1, Tamai I2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Jan;44(1):16-27. doi: 10.1124/dmd.115.067074. Epub 2015 Oct 26.
- To quantitatively understand the events in the human liver, we modeled a hepatic disposition of bosentan and its three known metabolites (Ro 48-5033, Ro 47-8634, and Ro 64-1056) in sandwich-cultured human hepatocytes based on the known metabolic pathway. In addition, the hepatotoxicity of Ro 47-8634
- PMID 26502773
- Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.
- Hong Y1, Chia YM1, Yeo RH1, Venkatesan G1, Koh SK1, Chai CL1, Zhou L1, Kojodjojo P1, Chan EC2.
- Molecular pharmacology.Mol Pharmacol.2016 Jan;89(1):1-13. doi: 10.1124/mol.115.100891. Epub 2015 Oct 21.
- Dronedarone is an antiarrhythmic agent approved in 2009 for the treatment of atrial fibrillation. An in-house preliminary study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent manner. This study aimed to investigate the inactivation of CYP450 by dronedaro
- PMID 26490246
- A New Covalent Inhibitor of Class C β-Lactamases Reveals Extended Active Site Specificity.
- Tilvawala R1, Cammarata M2, Adediran SA1, Brodbelt JS2, Pratt RF1.
- Biochemistry.Biochemistry.2015 Dec 11. [Epub ahead of print]
- O-Aryloxycarbonyl hydroxamates have previously been shown to efficiently inactivate class C β-lactamases by cross-linking serine and lysine residues in the active site. A new analogue of these inhibitors, d-(R)-O-(phenoxycarbonyl)-N-[(4-amino-4-carboxy-1-butyl)oxycarbonyl]hydroxylamine, designed to
- PMID 26651220
Japanese Journal
- 直腸カルチノイドに対し低位前方切除術を施行した遺伝性血管性浮腫の1例
- 中安 靖代,吉松 和彦,中山 真緒,矢野 有紀,横溝 肇,山口 健太郎,塩澤 俊一,島川 武,勝部 隆男,成高 義彦
- 日本消化器外科学会雑誌 47(12), 826-831, 2014
- 遺伝性血管浮腫（hereditary angioedema；以下，HAEと略記）は，局所的な浮腫によって腹痛や呼吸困難などを起こす疾患で，気管内挿管が必要な全身麻酔における周術期管理において厳重な注意が必要とされている．今回，我々はHAEに併存した直腸カルチノイドの手術例を経験し，独自な周術期管理によって安全に低位前方切除術を施行したので報告する．症例は60歳の男性で，血便を主訴に当院を受診した …
- NAID 130004714292
- 腹痛発作を繰り返し,C1インアクチベータ投与にて管理した先天性クインケ浮腫合併妊娠の一例
- 東上 加波,小林 康祐,鈴木 由梨奈 [他]
- 千葉産科婦人科学会雑誌 6(1), 15-17, 2012
- NAID 40019413640
- Reno-protective Role of Flunarizine (Mitochondrial Permeability Transition Pore Inactivator) against Gentamicin Induced Nephrotoxicity in Rats
- Muthuraman Arunachalam,Singla Sumeet Kumar,Rana Ajay [他],SINGH Atinderjeet,SOOD Shailja
- 薬学雑誌. 乙号 131(3), 437-443, 2011
- This study was aimed to evaluate the role of flunarizine on gentamicin (GEM) induced nephrotoxicity in rat. Administration of GEM (40 mg/kg, s.c. for 10 consecutive days) significantly increased blo …
- NAID 130000678909
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- inactivator 【名】不活性化因子、不活性化剤、阻害剤 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。
- Abstract The role of C1- inactivator (C1(-)-In) during activation of the classical complement pathway by soluble immune complexes was studied using purified human complement components C1, C4 and C1(-)-In, and stabilized soluble ...
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| 拡張検索 | 「plasminogen inactivator」「complement inactivator protein」 |