B-cell chronic lymphocytic leukemia

出典: meddic


chronic B-cell leukemia、chronic lymphocytic leukemialymphocytic lymphomasmall lymphocytic lymphomasmall-cell lymphoma

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/17 10:54:11」(JST)

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  • B-cell receptor signaling in the pathogenesis of lymphoid malignancies.
  • Bojarczuk K1, Bobrowicz M1, Dwojak M1, Miazek N2, Zapala P2, Bunes A2, Siernicka M1, Rozanska M2, Winiarska M3.
  • Blood cells, molecules & diseases.Blood Cells Mol Dis.2015 Oct;55(3):255-65. doi: 10.1016/j.bcmd.2015.06.016. Epub 2015 Jul 11.
  • B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a major driver in the pathogenesis of B-cell malignancies. As a result, a vast array of BCR-associated kinases has emerged as
  • PMID 26227856
  • Ibrutinib: from bench side to clinical implications.
  • Grisafi D1, Maestro A, Grumi C, Piazzoni L, Tirone G, Fiore W, Tessari R, Gianardi V, Gatti M, Tasca F, Generali D, Ravelli A, Lanza F, Scaglione F.
  • Medical oncology (Northwood, London, England).Med Oncol.2015 Sep;32(9):669. doi: 10.1007/s12032-015-0669-9. Epub 2015 Jul 30.
  • The activation of the B cell receptor (BCR) is nowadays known to play a primary role in the etiopathogenesis of a multitude of B cell malignancies, being one of the main factors responsible for the enhanced proliferation and survival of transformed cells. Thanks to the characterization and continuou
  • PMID 26223732
  • ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy.
  • Bystry V1, Agathangelidis A2, Bikos V1, Sutton LA3, Baliakas P3, Hadzidimitriou A4, Stamatopoulos K4, Darzentas N5.
  • Bioinformatics (Oxford, England).Bioinformatics.2015 Aug 6. pii: btv456. [Epub ahead of print]
  • MOTIVATION: An ever-increasing body of evidence supports the importance of B cell receptor immunoglobulin (BcR IG) sequence restriction, alias stereotypy, in chronic lymphocytic leukemia (CLL). This phenomenon accounts for ~30% of studied cases, one in eight of which belong to major subsets, and ext
  • PMID 26249808


  • 同種移植におけるCAR-T細胞療法
  • 白血化をきたすB細胞リンパ腫疾患群と慢性リンパ性白血病の鑑別のポイント (特集 低悪性度B細胞腫瘍の診療と研究の新展開)
  • 低悪性度B細胞リンパ腫と慢性リンパ性白血病の疫学 : 米国と日本の比較 (特集 低悪性度B細胞腫瘍の診療と研究の新展開)


Chronic lymphocytic leukemia (CLL) is a type of cancer that starts from white blood cells (called lymphocytes) in the bone marrow. Learn more here. ... Cancer starts when cells in the body begin to grow out of control.
1. Annu Rev Immunol. 2003;21:841-94. Epub 2001 Dec 19. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Chiorazzi N(1), Ferrarini M. Author information: (1)North Shore ...



先読みB細胞慢性リンパ球性白血病」「chronic lymphocytic leukemia」「small lymphocytic lymphoma
リンク元B細胞性慢性リンパ性白血病」「small-cell lymphoma」「lymphocytic lymphoma」「慢性Bリンパ性白血病」「B-CLL


  [★] B細胞性慢性リンパ性白血病

chronic lymphocytic leukemia」

  [★] 慢性リンパ性白血病 CLL

small lymphocytic lymphoma」

  [★] 小リンパ球性リンパ腫



B-cell chronic lymphocytic leukemia, B-CLL
慢性リンパ性白血病 CLLT細胞性慢性リンパ性白血病, T-CLL
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  • B細胞抗原(CD20)に加えCD5を発現

small-cell lymphoma」



B-cell chronic lymphocytic leukemia、chronic B-cell leukemia、chronic lymphocytic leukemialymphocytic lymphomasmall lymphocytic lymphoma

lymphocytic lymphoma」

  [★] リンパ球性リンパ腫

B-cell chronic lymphocytic leukemia、chronic B-cell leukemia、chronic lymphocytic leukemiasmall lymphocytic lymphomasmall-cell lymphoma



B-cell chronic lymphocytic leukemia


  [★] B細胞性慢性リンパ性白血病 B-cell chronic lymphocytic leukemia


  [★] 細胞

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「small room in which a monk or nun lives」

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「a device that delivers an electric current as the result of a chemical reaction」
electric cell

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「a room where a prisoner is kept」
jail cell, prison cell

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「(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals」

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「any small compartment; "the cells of a honeycomb"」

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「a small unit serving as part of or as the nucleus of a larger political movement」

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「(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞」



  • adj.
  • 慢性の、慢性的な、慢性型の

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「being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"」

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「(病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった」

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「of long duration; "chronic money problems"」

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「habitual; "a chronic smoker"」



  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

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「the 2nd letter of the Roman alphabet」

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「the blood group whose red cells carry the B antigen」
type B, group B


  [★] 白血病

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「malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer」
leukaemia, leucaemia, cancer of the blood

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  • adj.

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「of or relating to lymphocytes; "lymphocytic leukemia"」