B-cell-specific activator protein

出典: meddic

B細胞特異的活性化タンパク質B細胞特異的アクチベータータンパク質

B-cell-specific transcription factorBSAP

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英文文献

  • One missense mutation in exon 2 of the PAX5 gene in Iran.
  • Yazdanparast S1, Khatami SR1, Galehdari H1, Jaseb K2.
  • Genetics and molecular research : GMR.Genet Mol Res.2015 Dec 22;14(4):17768-75. doi: 10.4238/2015.December.22.1.
  • The PAX5 gene, which encodes the B-cell specific activator protein, is one of the most important factors in determination of B-cell development. This gene is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). For example, point mutations, deletions, as well as other gene
  • PMID 26782422
  • Non-coding recurrent mutations in chronic lymphocytic leukaemia.
  • Puente XS1, Beà S2, Valdés-Mas R1, Villamor N3, Gutiérrez-Abril J1, Martín-Subero JI4, Munar M5, Rubio-Pérez C6, Jares P7, Aymerich M3, Baumann T8, Beekman R2, Belver L9, Carrio A3, Castellano G2, Clot G2, Colado E10, Colomer D3, Costa D3, Delgado J8, Enjuanes A7, Estivill X11, Ferrando AA9, Gelpí JL5, González B3, González S5, González M12, Gut M13, Hernández-Rivas JM12, López-Guerra M3, Martín-García D2, Navarro A2, Nicolás P14, Orozco M5, Payer ÁR10, Pinyol M7, Pisano DG15, Puente DA1, Queirós AC4, Quesada V1, Romeo-Casabona CM14, Royo C2, Royo R5, Rozman M3, Russiñol N2, Salaverría I2, Stamatopoulos K16, Stunnenberg HG17, Tamborero D6, Terol MJ18, Valencia A15, López-Bigas N6, Torrents D5, Gut I13, López-Guillermo A8, López-Otín C1, Campo E3.
  • Nature.Nature.2015 Oct 22;526(7574):519-24. doi: 10.1038/nature14666. Epub 2015 Jul 22.
  • Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a pr
  • PMID 26200345
  • Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
  • Duque-Afonso J, Feng J, Scherer F, Lin CH, Wong SH, Wang Z, Iwasaki M, Cleary ML.
  • The Journal of clinical investigation.J Clin Invest.2015 Sep;125(9):3667-80. doi: 10.1172/JCI81158. Epub 2015 Aug 24.
  • Acute lymphoblastic leukemia (ALL) is the most common childhood cancer; however, its genetic diversity limits investigation into the molecular pathogenesis of disease and development of therapeutic strategies. Here, we engineered mice that conditionally express the E2A-PBX1 fusion oncogene, which re
  • PMID 26301816

和文文献

  • Prednisolone Sodium Succinate Down-Regulates BSAP/Pax5 and Causes a Growth Arrest in the Nalm6 Pre-B Cell Line.
  • The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: A B cell-specific trans-activator that describes a new DNA-binding protein family
  • The immunoglobulin heavy chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family.

関連リンク

BSAP は paired box protein 5 (Pax5) としても知られている、B 細胞に発現している転写因子です。BSAP は PAX 遺伝子ファミリーの一員として B 細胞の分化に関与している転写因子をコードしており、pro-, pre-, 成熟 B 細胞に発現が ...
1. Blood. 1998 Aug 15;92(4):1308-16. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Krenacs L(1), Himmelmann AW, Quintanilla ...

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★リンクテーブル★
先読みBSAP
リンク元B細胞特異的活性化タンパク質」「B細胞特異的アクチベータータンパク質」「B-cell-specific transcription factor
関連記事specific」「cell」「B」「protein」「activator

BSAP」

  [★]

B-lineage-specific activator protein


B細胞特異的活性化タンパク質」

  [★]

B-cell-specific activator proteinBSAP
B細胞特異的アクチベータータンパク質

B細胞特異的アクチベータータンパク質」

  [★]

B-cell-specific activator protein
B細胞特異的活性化タンパク質


B-cell-specific transcription factor」

  [★]

B細胞特異的転写因子

B-cell-specific activator protein

specific」

  [★]

  • adj.
  • (~に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
  • (比較)(限定)特定の(particular)、一定の(⇔general)
  • (~に)特有の、独特の(to)
  • (比較)(医学)(~に)渡航のある(for)。特殊な
  • (生物)(生物)種の
  • 医学)特異の
  • (物理)比の。物質固有の。単位質量・長さ・面積・容積で

n.

specificallyspecificity

WordNet   license wordnet

「stated explicitly or in detail; "needed a specific amount"」

WordNet   license wordnet

「a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"」

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「(sometimes followed by `to'」

WordNet   license wordnet

「being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"」

WordNet   license wordnet

「relating to or distinguishing or constituting a taxonomic species; "specific characters"」

PrepTutorEJDIC   license prepejdic

「《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)」

cell」

  [★] 細胞

WordNet   license wordnet

「small room in which a monk or nun lives」
cubicle

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「a device that delivers an electric current as the result of a chemical reaction」
electric cell

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「a room where a prisoner is kept」
jail cell, prison cell

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「(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals」

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「any small compartment; "the cells of a honeycomb"」

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「a small unit serving as part of or as the nucleus of a larger political movement」
cadre

PrepTutorEJDIC   license prepejdic

「(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞」


B」

  [★]

  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

WordNet   license wordnet

「the 2nd letter of the Roman alphabet」
b

WordNet   license wordnet

「the blood group whose red cells carry the B antigen」
type B, group B

protein」

  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic

「蛋白(たんばく)質」

activator」

  [★]

  • n.


WordNet   license wordnet

「(biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription」




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