アルサス現象
WordNet
- any state or process known through the senses rather than by intuition or reasoning
- a remarkable development
PrepTutorEJDIC
- 『現象』 / 驚くべきこと(物),非凡な人
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/07 17:04:36」(JST)
[Wiki en表示]
| Arthus reaction |
| Classification and external resources |
| Specialty |
emergency medicine |
| ICD-10 |
T78.4 |
| ICD-9-CM |
995.21 |
| DiseasesDB |
33220 |
| MeSH |
D001183 |
|
[edit on Wikidata]
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In immunology, the Arthus reaction (, ) is a type of local type III hypersensitivity reaction. Type III hypersensitivity reactions are immune complex-mediated, and involve the deposition of antigen/antibody complexes mainly in the vascular walls, serosa (pleura, pericardium, synovium), and glomeruli. This reaction is usually encountered in experimental settings following the injection of antigens.
Contents
- 1 History
- 2 Process
- 3 See also
- 4 References
History
The Arthus reaction was discovered by Nicolas Maurice Arthus in 1903.[1] Arthus repeatedly injected horse serum subcutaneously into rabbits. After four injections, he found that there was edema and that the serum was absorbed slowly. Further injections eventually led to gangrene.
Process
The Arthus reaction involves the in situ formation of antigen/antibody complexes after the intradermal injection of an antigen. If the animal/patient was previously sensitized (has circulating antibody), an Arthus reaction occurs. Typical of most mechanisms of the type III hypersensitivity, Arthus manifests as local vasculitis due to deposition of IgG-based immune complexes in dermal blood vessels. Activation of complement primarily results in cleavage of soluble complement proteins forming C5a and C3a, which activate recruitment of PMNs and local mast cell degranulation (requiring the binding of the immune complex onto FcγRIII[2]), resulting in an inflammatory response. Further aggregation of immune complex-related processes induce a local fibrinoid necrosis with ischemia-aggravating thrombosis in the tissue vessel walls.[3] The end result is a localized area of redness and induration that typically lasts a day or so.
Arthus reactions have been infrequently reported after vaccinations containing diphtheria and tetanus toxoid. The CDC's description:
Arthus reactions (type III hypersensitivity reactions) are rarely reported after vaccination and can occur after tetanus toxoid–containing or diphtheria toxoid–containing vaccines. An Arthus reaction is a local vasculitis associated with deposition of immune complexes and activation of complement. Immune complexes form in the setting of high local concentration of vaccine antigens and high circulating antibody concentration. Arthus reactions are characterized by severe pain, swelling, induration, edema, hemorrhage, and occasionally by necrosis. These symptoms and signs usually occur 4–12 hours after vaccination. ACIP has recommended that persons who experienced an Arthus reaction after a dose of tetanus toxoid–containing vaccine should not receive Td more frequently than every 10 years, even for tetanus prophylaxis as part of wound management.[4]
See also
References
- ^ Injections répétées de serum du cheval chez le lapin, Comptes rendus des séances de la Société de biologie et de ses filiales, Paris, 55 (1903), 817–820.
- ^ Parham, Peter (2009). "12". The Immune System (3rd ed.). New York, NY: Garland Science. p. 390.
- ^ Kumar, Vinay; Abbas, A.K.; Fausto, N; Aster, J.C. (2010). "6". In William Schmitt. Robbins and Cotran Pathologic Basis of Disease (8th ed.). Philadelphia: Saunders Elsevier. p. 205.
- ^ Preventing Tetanus, Diphtheria, and Pertussis Among Adolescents: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines, K. R. Broder et al., MMWR Recommendations and Reports, March 24, 2006 / 55(RR03), 1–34, page 18.
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Consequences of external causes (T66–T78, 990–995)
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| Temperature/radiation |
- elevated temperature
- Hyperthermia
- Heat syncope
- reduced temperature
- Hypothermia
- Immersion foot syndromes
- Trench foot
- Tropical immersion foot
- Warm water immersion foot
- Chilblains
- Frostbite
- Aerosol burn
- Cold intolerance
- Acrocyanosis
- Erythrocyanosis crurum
- radiation
- Radiation poisoning
- Radiation burn
- Chronic radiation keratosis
- Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
- Radiation acne
- Radiation cancer
- Radiation recall reaction
- Radiation-induced erythema multiforme
- Radiation-induced hypertrophic scar
- Radiation-induced keloid
- Radiation-induced morphea
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| Air |
- Hypoxia/Asphyxia
- Barotrauma
- Aerosinusitis
- Decompression sickness
- High altitude
- Altitude sickness
- Chronic mountain sickness
- HAPE
- HACE
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| Food |
|
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| Maltreatment |
- Physical abuse
- Sexual abuse
- Psychological abuse
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| Travel |
- Motion sickness
- Seasickness
- Airsickness
- Space adaptation syndrome
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| Adverse effect |
- Hypersensitivity
- Anaphylaxis
- Angioedema
- Allergy
- Arthus reaction
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| Other |
- Electric shock
- Drowning
- Lightning injury
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Ungrouped
skin conditions
resulting from
physical factors |
- Dermatosis neglecta
- Pinch mark
- Pseudoverrucous papules and nodules
- Sclerosing lymphangiitis
- Tropical anhidrotic asthenia
- UV-sensitive syndrome
- environmental skin conditions
- Electrical burn
- frictional/traumatic/sports
-
- Black heel and palm
- Equestrian perniosis
- Jogger's nipple
- Pulling boat hands
- Runner's rump
- Surfer's knots
- Tennis toe
- Vibration white finger
- Weathering nodule of ear
- Wrestler's ear
- Coral cut
- Painful fat herniation
- Uranium dermatosis
- iv use
-
- Skin pop scar
- Skin track
- Slap mark
- Pseudoacanthosis nigricans
- Narcotic dermopathy
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Hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
| Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- common allergies include: Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
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| Autoimmune |
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Type II/ADCC
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| Foreign |
- Hemolytic disease of the newborn
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| Autoimmune |
| Cytotoxic |
- Autoimmune hemolytic anemia
- Immune thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
- Guillain–Barré syndrome
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| "Type V"/receptor |
- Graves' disease
- Myasthenia gravis
- Pernicious anemia
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Type III
(Immune complex) |
| Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
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| Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
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Type IV/cell-mediated
(T cells) |
| Foreign |
- Allergic contact dermatitis
- Mantoux test
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| Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
- Postorgasmic illness syndrome
- Reactive arthritis
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| GVHD |
- Transfusion-associated graft versus host disease
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Unknown/
multiple |
| Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
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| Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
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UpToDate Contents
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English Journal
- The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
- Kovács M1, Németh T1, Jakus Z1, Sitaru C2, Simon E1, Futosi K3, Botz B4, Helyes Z4, Lowell CA5, Mócsai A6.
- The Journal of experimental medicine.J Exp Med.2014 Sep 22;211(10):1993-2011. doi: 10.1084/jem.20132496. Epub 2014 Sep 15.
- Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly understood. We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lacking the Src fa
- PMID 25225462
- Occurrence of congenital cerebral theileriosis in a newborn twin Holstein calves in Iran: Case report.
- Tolouei Kaleibar M1, Ashrafi Helan J2, Fathi E1.
- Veterinary research forum : an international quarterly journal.Vet Res Forum.2014 Summer;5(3):237-41.
- An 8-day-old newborn female twin Holstein calves with a history of weakness, anorexia, emaciation and convulsion were presented to Tabriz University Veterinary Teaching Hospital. On admission, the calves were febrile and recumbent. Physical examination revealed many ticks from the external body surf
- PMID 25568725
- β7 Integrin controls mast cell recruitment, whereas αE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury.
- Yamada D1, Kadono T, Masui Y, Yanaba K, Sato S.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 May 1;192(9):4112-21. doi: 10.4049/jimmunol.1300926. Epub 2014 Mar 26.
- Immune complex (IC) deposition causes significant tissue injury associated with various autoimmune diseases such as vasculitis. In the cascade of inflammation, cell-to-cell and cell-to-matrix adhesion via adhesion molecules are essential. To assess the role of αE and β7 integrin in IC-mediated tis
- PMID 24670804
Japanese Journal
- 抗真菌剤ラノコナゾールのアルツス現象並びにTNF産生とその作用に対する抑制効果
- 日本医真菌学会雑誌 = Japanese journal of medical mycology 41(2), 97-102, 2000-04-30
- NAID 10006591372
- 抗真菌剤ラノコナゾールのアルツス現象並びにＴＮＦ産生とその作用に対する抑制効果
- 新抗アレルギー性ポリペプタイド (MS-antigen) 投与による皮内反応閾値ならびに血清IgEに及ぼす効果と臨床成績の関係について
Related Links
- Arthus phenomenon, local swelling, redness, and tissue death following skin injection of soluble antigen into a subject previously immunized by a series of similar injections. The tissue damage is a result of the precipitation of antigen–antibody complexes in the walls of the blood vessels; the deposits are then ingested (phagocytosed) by neutrophilic white blood cells. The phenomenon is ...
- アルチュス現象【Arthus phenomenon】 アルツス反応，アルサス現象＊などとも呼ばれる．沈降抗体をもつ動物に抗原を皮内注射すると，数時間以内に浮腫や出血，壊死を伴う炎症性の反応が起きる．ウサギの皮下にウマ血清を繰り返し ...
- This antigen-antibody complex results in the activation of complement and release of chemotactic and vasoactive factors (type III). An Arthus reaction can be produced by a large variety of antigens, including commonly used therapeutic agents such as penicillin, aminosalicylic acid and streptomycin.
★リンクテーブル★
[★]
- 英
- Arthus' reaction, Arthus reaction
- 同
- Arthus反応, アルツス型反応 Arthus type-reaction、アルチュス反応、アルチュス現象(⇔血清病型反応 Seurm disese type-reaction)、アルサス現象, Arthus現象, Arthus' phenomenon, Arthus phenomenon
- 関
- III型アレルギー type III hypersensitivity reaction、アルサス
[show details]
アルツス型反応 : 約 11 件
アルサス型反応 : 92 件
アルサス反応 : 約 1,310 件
アルツス反応 : 約 357 件
- III型アレルギーの反応
- 侵入物が抗原で、反応が局所的な場合 (local ummunoe complex disease)
- 急性免疫複合体血管炎による組織壊死像を呈する。抗原に感作された動物・人の皮下に抗原を接種すると、抗原が血管壁に拡散し、その場所で免疫複合体が形成され、炎症が起こる。この炎症はsystemic immune complex diseaseと同じである。アルサス反応は2,3時間で発現し、4-10時間でピークに達する。抗原を摂取した部位は出血をともあった浮腫が形成されるが、時には潰瘍化する。(BPT.127)
[★]
- 関
- consequence、event、phenomena、phenomenal
[★]
アルサス、アルツス、アルザス、アルチュス