Alzheimer disease

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/17 17:19:13」(JST)

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  • Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment.
  • Ye BS, Seo SW, Kim CH, Jeon S, Kim GH, Noh Y, Cho H, Yoon CW, Kim HJ, Jang EY, Lee J, Kim JH, Chin J, Lee JM, Kim JH, Seong JK, Kim CH, Choe YS, Lee KH, Na DL.SourceDepartment of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
  • Neurobiology of aging.Neurobiol Aging.2014 Feb;35(2):291-300. doi: 10.1016/j.neurobiolaging.2013.08.017. Epub 2013 Sep 27.
  • Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwen
  • PMID 24080178
  • No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals.
  • Bi R, Zhao L, Zhang C, Lu W, Feng JQ, Wang Y, Ni J, Zhang J, Li GD, Hu QX, Wang D, Yao YG, Li T.SourceKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing, China.
  • Neurobiology of aging.Neurobiol Aging.2014 Feb;35(2):444.e5-9. doi: 10.1016/j.neurobiolaging.2013.08.013. Epub 2013 Sep 27.
  • The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independe
  • PMID 24080176
  • A 2-process model for neuropathology of Alzheimer's disease.
  • Mungas D, Tractenberg R, Schneider JA, Crane PK, Bennett DA.SourceDepartment of Neurology, School of Medicine, University of California, Davis, CA, USA. Electronic address:
  • Neurobiology of aging.Neurobiol Aging.2014 Feb;35(2):301-8. doi: 10.1016/j.neurobiolaging.2013.08.007. Epub 2013 Sep 27.
  • This study examined relations among neuritic and diffuse plaques, neurofibrillary tangles, age, and apolipoprotein E (APOE) in 2 large samples of neuropathology cases, the Religious Orders Study and the Memory and Aging Project. Cognitive status ranged from normal to demented and AD neuropathology r
  • PMID 24080173



Alzheimer's Association national site – information on Alzheimer’s disease and dementia symptoms, diagnosis, stages, treatment, care and support resources. ... News | Events | Press | Contact 24/7 Helpline: 1.800.272.3900 Find ...
Neuropathology Alzheimer's disease is characterised by loss of neurons and synapses in the cerebral cortex and certain subcortical regions. This loss results in gross atrophy of the affected regions, including degeneration in the temporal lobe ...



リンク元アルツハイマー病」「presenile dementia」「senile dementia」「late-onset Alzheimer disease
拡張検索early-onset Alzheimer disease



Alzheimer disease, Alzheimer's disease
(国試)Alzheimer病、(以下、厳密には同義ではない)→アルツハイマー型認知症アルツハイマー型痴呆 dementia of the Alzheimer type DAT, Alzheimer-type dementia Alzheimer type dementia ATD


  • 進行性痴呆のなかで脳血管障害による痴呆に次いで多い (EPT.257)
  • 大脳皮質のびまん性萎縮が見られる (EPT.257)
  • 前脳基底野コリン作動性ニューロンの選択的な変性が見られ、アセチルコリンの産生が低下
  • 病理学的には、老人斑とアルツハイマー神経線維変化が見られる (EPT.257)


  • 認知症
  • 有病率:65歳以上5-10%。65~69歳:1.5%、85歳~:27.3%。
  • 認知症の半数がアルツハイマー病
  • アルツハイマー病の5-10%が家族性


  • 高コレステロール
  • 血圧
  • ホモシステイン
  • 糖尿病。内臓脂肪(メタボリックシンドローム)
  • 喫煙


  • 老人斑:細胞外にβアミロイドが沈着。
  • 神経原線維変化:細胞内にリン酸化されたタウ蛋白が凝集し、らせん構造をとる


1. 中核症状

  • 1. 健忘(記銘力、記憶力)
  • 2. 見当識障害
  • 3. 思考力障害
  • 4. 計算力障害

2. 周辺症状

  • 不安、抑うつ、徘徊、不眠、妄想、せん妄、幻覚、暴行、焦燥感


  • 人格の変化
  • アルツハイマー病:晩期
  • Pick病:早期


  • 空間視の障害:例えば立方体の模写ができない。頭頂葉の障害とされる。
  • 着衣失行


  • CT:側脳室の拡大、側頭葉の萎縮


  • MRI
  • T1:海馬の萎縮



presenile dementia」


Alzheimer diseaseAlzheimer's diseaseearly-onset Alzheimer diseaselate-onset Alzheimer diseasesenile dementia

senile dementia」

  [★] 老年認知症老年痴呆

Alzheimer diseaseAlzheimer's diseaseearly-onset Alzheimer diseaselate-onset Alzheimer diseasepresenile dementia

late-onset Alzheimer disease」


Alzheimer diseaseAlzheimer's diseaseearly-onset Alzheimer diseasepresenile dementiasenile dementia

early-onset Alzheimer disease」



Alzheimer diseaseAlzheimer's diseaselate-onset Alzheimer diseasepresenile dementiasenile dementia



  • n.
疾患illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
  • something that is very wrong with people's attitudes, way of life or with society.
ailailmentdisease entitydisorderillillnessmaladysicksickness
  • 注意

WordNet   license wordnet

「an impairment of health or a condition of abnormal functioning」

PrepTutorEJDIC   license prepejdic

「(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊」

PrepTutorEJDIC   license prepejdic

「女性の話術芸人 =diseur」



WordNet   license wordnet

「caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes"」
morbid, pathologic, pathological

PrepTutorEJDIC   license prepejdic

「病気にかかった / 病的な,不健全な(morbid)」