WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

answer / ampere
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/07 16:31:52」(JST)

wiki en

[Wiki en表示]

An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.^[1]

Mechanism

NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.

ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.

There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.

Types

There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.

References

^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. doi:10.1139/cjpp-79-8-665. PMID 11558675.

External links

Atrial Natriuretic Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
2. 心臓リモデリング：臨床的評価および治療 cardiac remodeling clinical assessment and therapy
3. 造影剤誘発性腎症の予防 prevention of contrast induced nephropathy
4. 低アルドステロン症（4型RTA）の病因、診断、および治療 etiology diagnosis and treatment of hypoaldosteronism type 4 rta
5. 治療抵抗性高血圧の治療 treatment of resistant hypertension

English Journal

Effect of Chaiqin Chengqi Decoction () on cholecystokinin receptor 1-mediated signal transduction of pancreatic acinar cells in acute necrotizing pancreatitis rats.

Guo J1, Jin T, Lin ZQ, Wang XX, Yang XN, Xia Q, Xue P.
Chinese journal of integrative medicine.Chin J Integr Med.2015 Jan;21(1):29-35. doi: 10.1007/s11655-014-1750-5. Epub 2014 May 10.
OBJECTIVE: To investigate the effect of Chaiqin Chengqi Decoction (,CQCQD) on cholecystokinin receptor 1 (CCKR1)-mediated signal transduction of pancreatic acinar cell in rats with acute necrotic pancreatitis (ANP).METHODS: Twenty-seven Sprague-Dawley rats were randomized into three groups: the cont
PMID 24817315

Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic Peptide in hypertensive subjects with type 2 diabetes.

Lovshin JA1, Barnie A2, DeAlmeida A3, Logan A1, Zinman B4, Drucker DJ5.
Diabetes care.Diabetes Care.2015 Jan;38(1):132-9. doi: 10.2337/dc14-1958. Epub 2014 Nov 20.
OBJECTIVE: GLP-1 receptor (GLP-1R) agonists induce natriuresis and reduce blood pressure (BP) through incompletely understood mechanisms. We examined the effects of acute and 21-day administration of liraglutide on plasma atrial natriuretic peptide (ANP), urinary sodium excretion, office and 24-h BP
PMID 25414155

Role of atrial natriuretic Peptide in oxytocin induced cardioprotection.

Houshmand F1, Faghihi M2, Zahediasl S3.
Heart, lung & circulation.Heart Lung Circ.2015 Jan;24(1):86-93. doi: 10.1016/j.hlc.2014.05.023. Epub 2014 Jun 30.
BACKGROUND: The purpose of this study was to determine whether endogenous atrial natriuretic peptide (ANP) contributes to the protective effect of neurohypophysial hormone oxytocin (OT) in heart preconditioning.METHODS: Sprague-Dawley male rats were subjected to 25min regional ischaemia and 120min r
PMID 25126708

Japanese Journal

Angiotensin Ⅱ receptor・neprilysin同時拮抗剤 : LCZ696について

循環器内科 75(3), 288-294, 2014-03
NAID 40020021051

Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats

Endocrine journal 60(5), 571-581, 2013-05-01
NAID 10031184524

A-Type Natriuretic Peptide Level in Angiotensin Ⅱ Type 1a Receptor Knockout Mice

Experimental animals 61(2), 131-138, 2012-04-01
NAID 10030555858

Related Pictures

★リンクテーブル★

リンク元	「ANP受容体」「ANF receptor」「心房性ナトリウム利尿ペプチド受容体」「心房性ナトリウム利尿ペプチドレセプター」「ANPレセプター」
関連記事	「A」「AN」「ANP」

「ANP受容体」

natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C)
Identifiers
Symbol	NPR3
Alt. symbols	ANPRC, NPRC
Entrez	4883
HUGO	7945
OMIM	108962
RefSeq	NM_000908
UniProt	P17342
Other data
Locus	Chr. 5 p14-p1

natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B)
Identifiers
Symbol	NPR2
Alt. symbols	ANPRB, NPRB
Entrez	4882
HUGO	7944
OMIM	108961
RefSeq	NM_003995
UniProt	P20594
Other data
Locus	Chr. 9 p21-p12

natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A)
Identifiers
Symbol	NPR1
Alt. symbols	ANPRA, NPRA
Entrez	4881
HUGO	7943
OMIM	108960
RefSeq	NM_000906
UniProt	P16066
Other data
Locus	Chr. 1 q21-q22