WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
of or relating to a cavity or chamber in the body (especially one of the upper chambers of the heart)
amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein
of or relating to natriuresis

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/30 07:42:00」(JST)

wiki en

[Wiki en表示]

An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.^[1]

Mechanism

NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.

ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.

There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.

Types

There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.

References

^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. doi:10.1139/cjpp-79-8-665. PMID 11558675.

External links

Atrial Natriuretic Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. Chapter 6D：ナトリウム利尿ペプチド chapter 6d natriuretic peptides
2. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
3. 心臓リモデリング：臨床的評価および治療 cardiac remodeling clinical assessment and therapy
4. 低アルドステロン症（4型RTA）の病因、診断、および治療 etiology diagnosis and treatment of hypoaldosteronism type 4 rta
5. 造影剤誘発性腎症の予防 prevention of contrast induced nephropathy

English Journal

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes.

Cannon MV1, Silljé HH1, Sijbesma JW2, Khan MA1, Steffensen KR3, van Gilst WH1, de Boer RA4.
Diabetologia.Diabetologia.2016 Mar;59(3):634-43. doi: 10.1007/s00125-015-3827-x. Epub 2015 Dec 18.
AIMS/HYPOTHESIS: Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart
PMID 26684450

Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.

Kiguchi N1, Sukhtankar DD1, Ding H1, Tanaka K1, Kishioka S1, Peters CM1, Ko MC2.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15.
B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPRA) and gastrin-releasing peptide (GRP)-GRP receptor (GRPR) systems contribute to spinal processing of itch. However, pharmacological and anatomic evidence of these two spinal ligand-receptor systems are still not clear. The aim of t
PMID 26669425

Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway.

Zhang X1, Ma S1, Zhang R2, Li S1, Zhu D1, Han D1, Li X1, Li C1, Yan W2, Sun D1, Xu B2, Wang Y3, Cao F4.
Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2016 Feb 1. pii: gmv137. [Epub ahead of print]
It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was designed to determine the role of OSM in cardiom
PMID 26837420

Japanese Journal

Addition of a Nitric Oxide Donor to an Angiotensin II Type 1 Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects

International Heart Journal advpub(0), 2015
NAID 130005108319

Novel Diuretic Strategies for the Treatment of Heart Failure in Japan

Circulation Journal 78(8), 1816-1823, 2014
NAID 130004926994

Genetic factors associating the effects of habitual exercise on arterial stiffness

The journal of physical fitness and sports medicine : JPFSM 2(3), 325-332, 2013-08-25
NAID 10031179355

Related Pictures

★リンクテーブル★

リンク元	「ANP receptor」「心房性ナトリウム利尿ペプチド受容体」「心房性ナトリウム利尿ペプチドレセプター」
関連記事	「atrial」「peptide receptor」「natriuretic」「atrial natriuretic」「natriuretic peptide」

「ANP receptor」

natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C)
Identifiers
Symbol	NPR3
Alt. symbols	ANPRC, NPRC
Entrez	4883
HUGO	7945
OMIM	108962
RefSeq	NM_000908
UniProt	P17342
Other data
Locus	Chr. 5 p14-p1

natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B)
Identifiers
Symbol	NPR2
Alt. symbols	ANPRB, NPRB
Entrez	4882
HUGO	7944
OMIM	108961
RefSeq	NM_003995
UniProt	P20594
Other data
Locus	Chr. 9 p21-p12

natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A)
Identifiers
Symbol	NPR1
Alt. symbols	ANPRA, NPRA
Entrez	4881
HUGO	7943
OMIM	108960
RefSeq	NM_000906
UniProt	P16066
Other data
Locus	Chr. 1 q21-q22