…antivirals are inhibitors of the NS3/4A protease, the NS5A protein, and the NS5B polymerase. NS3/4A protease inhibitors are inhibitors of the NS3/4A serine protease, an enzyme involved in post-translational …
…lopinavir/ritonavir or other protease inhibitors associated with lipid abnormalities, we suggest a switch to an integrase inhibitor-based regimen . Alternatively, a protease inhibitor can be switched to …
…with other combination regimens that did not contain a protease inhibitor (OR 1.35, 95% CI 1.08-1.70). In a subsequent trial comparing a protease inhibitor-containing combination ART regimen with a triple-nucleoside …
…those <75 kg and 1200 mg for those ≥75 kg) is also effective for such protease-inhibitor failures . Although grazoprevir is also a protease inhibitor, it has a high threshold for resistance. The manufacturer …