ATM療法

関

潰瘍性大腸炎、AFM療法

• 慈恵医大柏病院（千葉県柏市）消化器・肝臓内科の大草敏史教授ら
• 抗生物質３剤を２週間服用するＡＴＭ療法を行うと、半数の患者の症状が著しく改善

• Fusobacterium variumがUCの発症に関与していると考えて考えられた治療
• レジメン

• アモキシシリン：oral amoxicillin 1500 mg/day
• テトラサイクリン：oral tetracycline 1500 mg/day
• メトロニダゾール：oral metronidazole 750 mg/day

PMID 20216533

Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial.

Ohkusa T, Kato K, Terao S, Chiba T, Mabe K, Murakami K, Mizokami Y, Sugiyama T, Yanaka A, Takeuchi Y, Yamato S, Yokoyama T, Okayasu I, Watanabe S, Tajiri H, Sato N; Japan UC Antibiotic Therapy Study Group.

Am J Gastroenterol. 2010 Aug;105(8):1820-9. Epub 2010 Mar 9.

PMID 16334443

Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up.

Ohkusa T, Nomura T, Terai T, Miwa H, Kobayashi O, Hojo M, Takei Y, Ogihara T, Hirai S, Okayasu I, Sato N.

Scand J Gastroenterol. 2005 Nov;40(11):1334-42.

PMID 15813838

Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy.

Nomura T, Ohkusa T, Okayasu I, Yoshida T, Sakamoto M, Hayashi H, Benno Y, Hirai S, Hojo M, Kobayashi O, Terai T, Miwa H, Takei Y, Ogihara T, Sato N.

Aliment Pharmacol Ther. 2005 Apr 15;21(8):1017-27.