コプロポルフィリノゲン酸化酵素 : 9 件
コプロポルフィリノーゲンオキシダーゼ : 73 件

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/05 01:04:15」(JST)

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コプロポルフィリノーゲンオキシダーゼ（coproporphyrinogen oxidase）は、ヒトのCPOX遺伝子にコードされている酵素である^[1]^[2]^[3]。この酵素はポルフィリン代謝の6番目の反応に関与し、コプロポルフィリノーゲンIIIをプロトポルフィリノーゲンIXに変換する。

コプロポルフィリノーゲンIII
プロトポルフィリノーゲンIX

脚注

^ Lamoril J, Martasek P, Deybach JC, Da Silva V, Grandchamp B, Nordmann Y (Jun 1995). “A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria”. Hum Mol Genet 4 (2): 275-8. PMID 7757079.
^ Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S (Nov 1993). “Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation”. J Biol Chem 268 (28): 21359-63. PMID 8407975.
^ “Entrez Gene: CPOX coproporphyrinogen oxidase”. 2008年2月22日閲覧。

参考文献

Fujita H, Kondo M, Taketani S, et al. (1995). “Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria.”. Hum. Mol. Genet. 3 (10): 1807–10. doi:10.1093/hmg/3.10.1807. PMID 7849704.
Cacheux V, Martasek P, Fougerousse F, et al. (1994). “Localization of the human coproporphyrinogen oxidase gene to chromosome band 3q12.”. Hum. Genet. 94 (5): 557–9. doi:10.1007/BF00211026. PMID 7959694.
Delfau-Larue MH, Martasek P, Grandchamp B (1995). “Coproporphyrinogen oxidase: gene organization and description of a mutation leading to exon 6 skipping.”. Hum. Mol. Genet. 3 (8): 1325–30. doi:10.1093/hmg/3.8.1325. PMID 7987309.
Martasek P, Nordmann Y, Grandchamp B (1994). “Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms.”. Hum. Mol. Genet. 3 (3): 477–80. doi:10.1093/hmg/3.3.477. PMID 8012360.
Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Martasek P, Camadro JM, Delfau-Larue MH, et al. (1994). “Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase.”. Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3024–8. doi:10.1073/pnas.91.8.3024. PMID 8159699.
Taketani S, Kohno H, Furukawa T, et al. (1994). “Molecular cloning, sequencing and expression of cDNA encoding human coproporphyrinogen oxidase.”. Biochim. Biophys. Acta 1183 (3): 547–9. doi:10.1016/0005-2728(94)90083-3. PMID 8286403.
Lamoril J, Deybach JC, Puy H, et al. (1997). “Three novel mutations in the coproporphyrinogen oxidase gene.”. Hum. Mutat. 9 (1): 78–80. doi:10.1002/(SICI)1098-1004(1997)9:1<78::AID-HUMU17>3.0.CO;2-M. PMID 8990017.
Daimon M, Gojyou E, Sugawara M, et al. (1997). “A novel missense mutation in exon 4 of the human coproporphyrinogen oxidase gene in two patients with hereditary coproporphyria.”. Hum. Genet. 99 (2): 199–201. doi:10.1007/s004390050338. PMID 9048920.
Schreiber WE, Zhang X, Senz J, Jamani A (1997). “Hereditary coproporphyria: exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene.”. Hum. Mutat. 10 (3): 196–200. doi:10.1002/(SICI)1098-1004(1997)10:3<196::AID-HUMU3>3.0.CO;2-H. PMID 9298818.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lamoril J, Puy H, Gouya L, et al. (1998). “Neonatal hemolytic anemia due to inherited harderoporphyria: clinical characteristics and molecular basis.”. Blood 91 (4): 1453–7. PMID 9454777.
Susa S, Daimon M, Kondo H, et al. (1999). “Identification of a novel mutation of the CPO gene in a Japanese hereditary coproporphyria family.”. Am. J. Med. Genet. 80 (3): 204–6. doi:10.1002/(SICI)1096-8628(19981116)80:3<204::AID-AJMG4>3.0.CO;2-G. PMID 9843038.
Rosipal R, Lamoril J, Puy H, et al. (1999). “Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update.”. Hum. Mutat. 13 (1): 44–53. doi:10.1002/(SICI)1098-1004(1999)13:1<44::AID-HUMU5>3.0.CO;2-Q. PMID 9888388.
Taketani S, Furukawa T, Furuyama K (2001). “Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells.”. Eur. J. Biochem. 268 (6): 1705–11. doi:10.1046/j.1432-1327.2001.02045.x. PMID 11248690.
Lamoril J, Puy H, Whatley SD, et al. (2001). “Characterization of mutations in the CPO gene in British patients demonstrates absence of genotype-phenotype correlation and identifies relationship between hereditary coproporphyria and harderoporphyria.”. Am. J. Hum. Genet. 68 (5): 1130–8. doi:10.1086/320118. PMID 11309681.
Elkon H, Don J, Melamed E, et al. (2003). “Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase.”. J. Mol. Neurosci. 18 (3): 229–38. doi:10.1385/JMN:18:3:229. PMID 12059041.
Wiman A, Floderus Y, Harper P (2002). “Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria.”. J. Hum. Genet. 47 (8): 407–12. doi:10.1007/s100380200059. PMID 12181641.

外部リンク

MeSH Coproporphyrinogen+III+Oxidases

UpToDate Contents

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1. 遺伝コプロポルフィリン症 hereditary coproporphyria
2. ALA脱水酵素欠損性ポルフィリン症 ala dehydratase porphyria
3. 先天性骨髄性ポルフィリン症 congenital erythropoietic porphyria
4. 異型ポルフィリン症 variegate porphyria
5. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias

Japanese Journal

コプロポルフィリノーゲンオキシダーゼのサブユニット構造について

吉永侃夫
日本分子生物学会年会プログラム・講演要旨集 19, 120, 1996-08
NAID 10002854349

「CPO」

コプロポルフィリノーゲンオキシダーゼ
識別子
EC番号	1.3.3.3
CAS登録番号	9076-84-0
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
遺伝子オントロジー	AmiGO / EGO
検索
PMC	articles
PubMed	articles