xylene poisoning

キシレン中毒

WordNet

1. the physiological state produced by a poison or other toxic substance (同)toxic condition, intoxication
2. the act of giving poison to a person or animal with the intent to kill
3. a colorless flammable volatile liquid hydrocarbon used as a solvent (同)xylol

UpToDate Contents

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English Journal

• Concentrations in human blood of petroleum hydrocarbons associated with the BP/Deepwater Horizon oil spill, Gulf of Mexico.

• Sammarco PW1, Kolian SR, Warby RA, Bouldin JL, Subra WA, Porter SA.
• Archives of toxicology.Arch Toxicol.2015 May 22. [Epub ahead of print]
• During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarb
• PMID 25998020

• Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties.

• Gupta B1, Singh N1, Sharma R1, Foretić B2, Musilek K3, Kuca K4, Acharya J5, Satnami ML1, Ghosh KK6.
• Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Oct 1;24(19):4743-8. doi: 10.1016/j.bmcl.2014.07.095. Epub 2014 Aug 14.
• The search of proficient oximes as reactivators of irreversibly inhibited-AChE by organophosphate poisoning necessitates an appropriate assessment of their physicochemical properties and reactivation kinetics. Therefore, herein acid dissociation constant; pKa, lipophilicity; logP, polar surface area
• PMID 25190468

• [9 cases with toxic encephalopathy induced by xylene].

• Ding G, Ren J, Yu S.
• Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi.2014 Sep;32(9):705.
• PMID 25511281

Japanese Journal

• 殺虫剤の誤吸入による喉頭炎例

• 耳鼻咽喉科臨床 105(9), 859-862, 2012
• NAID 130002141255

• シックビル症候群患者の臨床所見並びに環境測定結果について

• 産業衛生学雑誌 = Journal of occupational health 53(2), 25-32, 2011-03-20
• NAID 10027959175

• 平成７年から１８年までの我が国の有機溶剤中毒事例の解析

• 産業衛生学雑誌 53(3), 87, 2011
• NAID 130004743845

Related Links

• Xylene poisoning - RightDiagnosis.com - Right Diagnosis

Xylene poisoning symptoms, causes, diagnosis, and treatment information for Xylene poisoning (Chemical poisoning - Xylene) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and ...

• Xylene poisoning - definition of xylene poisoning by The Free ...

Define xylene poisoning. xylene poisoning synonyms, xylene poisoning pronunciation, xylene poisoning translation, English dictionary definition of xylene poisoning. n. 1. A substance that causes injury, illness, or death Bing ? ...

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★リンクテーブル★

リンク元

「キシレン中毒」

「キシレン中毒」

　　[★]

英

xylene poisoning

同

1,3-ジメチルベンゼン中毒 1,3-dimethylbenzene poisoning、キシロール中毒 xylol poisoning

関

キシレン

進入径路

• 経気道、経皮

作用機序

• 中枢神経：シナプスの刺激伝達抑制。長期的に脱髄

症状

• 急性：皮膚・粘膜刺激(上気道刺激)、中枢神経抑制

代謝

• H3C-benzen-ring-CH3　→　H3C-benzen-ring-COOH　－(グリシン抱合)→　H3C-benzen-ring-CO-NH-CH2COOH

• キシレンの95%がメチル安息香酸に代謝されグリシン抱合を受けてメチル馬尿酸となり尿中に排泄される

検査

• 尿中メチル馬尿酸の定量(構造式：C6H5(CH3)(CONHCH2COOH))

• 作業終了時に検体を採取する。
• 飲酒により影響をうける。

参考

• 1.

http://data.medience.co.jp/compendium/main.asp?ield=01&m_class=12&s_class=0001