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1. 肝細胞移植hepatocyte transplantation [show details]
… SV40 large T antigen) can be deleted prior to transplantation, have been developed and are being evaluated . Transplantation of hepatocytes from xenogeneic sources is also being explored, although major …
2. 異種移植および腎臓xenotransplantation and the kidney [show details]
… period of months is it likely that the porcine kidney will be used as a permanent xenogeneic transplant. The transplantation of cells, tissues, and organs between individuals of different species is referred …
3. 肝移植後の皮膚障害の概要overview of dermatologic problems following liver transplantation [show details]
…seen following liver transplantation. A detailed discussion of skin cancer following solid organ transplantation and the general management of patients following liver transplantation are discussed separately …
4. 肺移植：疾患に基づいた処置の選択lung transplantation disease based choice of procedure [show details]
…recover after lung transplantation alone can be difficult. Severe right ventricular dysfunction, for example, has reversed after isolated lung transplantation . Therefore, lung transplantation alone can be performed …
5. 成人の心肺移植heart lung transplantation in adults [show details]
…isolated heart transplantation and in this setting, heart-lung transplantation may be considered as an alternative. However, some centers have successfully performed heart transplantation in patients with …

English Journal

GDNF family receptor alpha 1 is a reliable marker of undifferentiated germ cells in bulls.

Kim YH, Choi YR, Kim BJ, Jung SE, Kim SM, Jin JH, Yun MH, Kim SU, Kim YH, Hwang S, Pang MG, Ryu BY.
Theriogenology. 2019 Jul;132()172-181.
Undifferentiated germ cells, including spermatogonial stem cells (SSCs), make up only a very small proportion of germ cells within the testis; for example, 0.03% of germ cells in the mouse testis are SSCs. In this study, we investigated the characteristics of bovine undifferentiated germ cells and d
PMID 31029848

Increased splenic human CD4:CD8 T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice.

Geraghty NJ, Belfiore L, Adhikary SR, Alexander SI, Sluyter R, Watson D.
Transplant immunology. 2019 06;54()38-46.
Graft-versus-host disease (GVHD) is a frequent complication following allogeneic hematopoietic stem cell transplantation (HSCT) with current therapies limited to general immunosuppression. Humanized mouse models of GVHD are emerging as valuable intermediaries to allow translation of findings from al
PMID 30743002

Biocompatibility and cellular compatibility of decellularized tracheal matrix derived from rabbits.

Zhang F, Wang Z, Zheng C, Zhao C, Shi H, Pan S, Zhang W.
The International journal of artificial organs. 2019 May;()391398819847216.
To study the different concentrations of Triton X-100 and nuclease needed to remove cells from the tracheal matrix of rabbits and analyse their biocompatibility and cellular compatibility. Fifty tracheas were harvested from donor New Zealand rabbits. Thirty tracheas were randomly divided into five g
PMID 31081418

Japanese Journal

Long-term (5 years) cryopreserved spermatogonia have high capacity to generate functional gametes via interspecies transplantation in salmonids

Lee Seungki,Yoshiko Iwasaki,Yoshizaki Goro
Cryobiology 73(2), 286-290, 2016-10
… After cryopreservation for 5 years in liquid nitrogen, intraperitoneally transplanted spermatogonia migrated toward, and incorporated into, the gonads of xenogeneic recipients. …
NAID 120006547602

Production of germ cell‐deficient salmonids by dead end gene knockdown, and their use as recipients for germ cell transplantation

Yoshizaki Goro,Kuniko Takashiba,Shotaro Shimamori,Kiyoko Fujinuma,Shinya Shikina,Tomoyuki Okutsu,Sachi Kume,Makoto Hayashi
Molecular Reproduction and Development 83(4), 298-311, 2016-02-09
… We previously established a spermatogonial transplantation using triploid recipients. … Therefore, in this study, to examine the possibility using germ cell-deficient fish as recipients, we studied biological characteristics of germ cell-deficient gonads in rainbow trout for their suitability as recipients for germ cell transplantation. …
NAID 120006620251

当科における異種移植研究の変遷と今後の展望

田原裕之,井手健太郎,大段秀樹
Organ Biology 23(2), 154-157, 2016
… Xenotransplantation using pig donors provides a potential solution to the shortage of donors in organ transplantation. … However, it had been proven that delayed xenograft rejection (DXR) including deposition of antibodies against non-Gal antigens and acute vascular rejection with macrophage infiltration caused in GalT knockout pig to non-human primate organ transplantation model. …
NAID 130005263593