WordNet

(mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"
a response that reveals a persons feelings or attitude; "he was pleased by the audiences reaction to his performance"; "John feared his mothers reaction when she saw the broken lamp"
a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age" (同)response
doing something in opposition to another way of doing it that you dont like; "his style of painting was a reaction against cubism"
an idea evoked by some experience; "his reaction to the news was to start planning what to do"
extreme conservatism in political or social matters; "the forces of reaction carried the election"

PrepTutorEJDIC

{名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用

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1. 薬物アレルギー：分類および臨床的特徴 drug allergy classification and clinical features
2. 分子標的剤およびその他の生物製剤を用いた癌治療による皮膚合併症 cutaneous complications of molecularly targeted therapy and other biologic agents used for cancer therapy
3. 癌治療に用いられる治療用モノクローナル抗体に対する輸注反応 infusion reactions to therapeutic monoclonal antibodies used for cancer therapy
4. 造影剤に対する即時型過敏反応：再発反応の予防 immediate hypersensitivity reactions to radiocontrast media prevention of recurrent reactions
5. 薬物アレルギー：病因 drug allergy pathogenesis

Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactions.

Venkatachalam A1, Parashar A2, Manoj KM3,4,5.
In silico pharmacology.In Silico Pharmacol.2016 Dec;4(1):2. doi: 10.1186/s40203-016-0016-7. Epub 2016 Feb 19.
PURPOSE: The currently held mechanistic understanding of microsomal cytochrome P450s (CYPs) seeks that diverse drug molecules bind within the deep-seated distal heme pocket and subsequently react at the heme centre. To explain a bevy of experimental observations and meta-analyses, we indulge a hypot
PMID 26894412

Mitchell SC1.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Aug;46(8):743-56. doi: 10.3109/00498254.2015.1109161. Epub 2015 Nov 26.
1. Although not unknown, the conjugation of a xenobiotic with phosphate appears a rarity amongst the routes available for foreign compound metabolism. This is especially true in mammals and may be somewhat surprising as conjugation with sulphate, a seemingly similar moiety, is commonplace. 2. In
PMID 26611118

Heterologous expression of fungal cytochromes P450 (CYP5136A1 and CYP5136A3) from the white-rot basidiomycete Phanerochaete chrysosporium: Functionalization with cytochrome b5 in Escherichia coli.

Hatakeyama M1, Kitaoka T2, Ichinose H3.
Enzyme and microbial technology.Enzyme Microb Technol.2016 Jul;89:7-14. doi: 10.1016/j.enzmictec.2016.03.004. Epub 2016 Mar 10.
Cytochromes P450 from the white-rot basidiomycete Phanerochaete chrysosporium, CYP5136A1 and CYP5136A3, are capable of catalyzing oxygenation reactions of a wide variety of exogenous compounds, implying their significant roles in the metabolism of xenobiotics by the fungus. It is therefore interesti
PMID 27233123