WordNet

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules.

Wang Y1, Benz FW1, Wu Y1, Wang Q1, Chen Y1, Chen X1, Li H1, Zhang Y1, Zhang R2, Yang J2.
Molecular pharmacology.Mol Pharmacol.2016 Feb;89(2):233-42. doi: 10.1124/mol.115.100149. Epub 2015 Dec 9.
Antibody-drug conjugates (ADCs) have achieved great success in cancer therapy in recent years. Some peptidyl microtubule inhibitors consisting of natural and unnatural amino acids, such as monomethyl auristatin E (MMAE) and F (MMAF), are extremely cytotoxic and have been used as a payload in ADCs. H
PMID 26660762

Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells.

Weiß LM1,2,3, Hugle M1, Romero S1, Fulda S1,2,3.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Jan 15;138(2):497-506. doi: 10.1002/ijc.29725. Epub 2015 Sep 1.
Since polo-like kinase 1 (PLK1) is highly expressed in Ewing sarcoma (ES), we evaluated the therapeutic potential of the PLK1 inhibitor BI 6727. Here, we identify a synergistic induction of apoptosis by BI 6727 and several microtubule-interfering drugs in ES cells, including vincristine (VCR), vinbl
PMID 26260582

Reduced intensity VEPEMB regimen compared with standard ABVD in elderly Hodgkin lymphoma patients: results from a randomized trial on behalf of the Fondazione Italiana Linfomi (FIL).

Zallio F1, Tamiazzo S1, Monagheddu C2, Merli F3, Ilariucci F3, Stelitano C4, Liberati AM5, Mannina D6, Vitolo U7, Angelucci E8, Rota Scalabrini D9, Vallisa D10, Bellei M11, Bari A11, Ciccone G2, Salvi F1, Levis A1.
British journal of haematology.Br J Haematol.2016 Jan 13. doi: 10.1111/bjh.13904. [Epub ahead of print]
Survival rates for elderly Hodgkin Lymphoma (HL) have not improved substantially in recent years, mainly because of a lack of prospective randomized studies, due to difficulties in enrolling patients. Between 2002 and 2006, 54 untreated HL patients, aged between 65 and 80 years and considered 'non-
PMID 26763986