UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 心不全患者における高血圧治療 treatment of hypertension in patients with heart failure
2. 心不全患者における利尿剤の使用 use of diuretics in patients with heart failure
3. 慢性僧帽弁閉鎖不全症の血管拡張療法 vasodilator therapy in chronic mitral regurgitation
4. 安定狭心症のマネージメントにおける硝酸塩 nitrates in the management of stable angina pectoris
5. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers

English Journal

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite.

Maher AR, Arif S, Madhani M, Abozguia K, Ahmed I, Fernandez BO, Feelisch M, O'Sullivan AG, Christopoulos A, Sverdlov AL, Ngo D, Dautov R, James PE, Horowitz JD, Frenneaux MP.Author information Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. abdul.r.maher@googlemail.comAbstractBACKGROUND AND PURPOSE: Nitrite (NO₂(-)) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂(-) in healthy volunteers and patients with stable congestive heart failure (CHF).
British journal of pharmacology.Br J Pharmacol.2013 Jun;169(3):659-70. doi: 10.1111/bph.12152.
BACKGROUND AND PURPOSE: Nitrite (NO₂(-)) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂(-) in healthy volunteers and patients with stable congestive heart failure (
PMID 23472879

Failed attempts and improvement strategies in peripheral intravenous catheterization.

Sabri A, Szalas J, Holmes KS, Labib L, Mussivand T.Author information Cardiovascular Devices Division, University of Ottawa Heart Institute, ON, Canada.AbstractBACKGROUND: Access to peripheral veins is necessary for sample collection, transfusion and infusion of fluids or medications. The peripheral intravenous catheterization (PIVC) procedure is the introduction of a short catheter into a peripheral vein and can be problematic, leading to multiple failed attempts.
Bio-medical materials and engineering.Biomed Mater Eng.2013;23(1-2):93-108. doi: 10.3233/BME-120735.
BACKGROUND: Access to peripheral veins is necessary for sample collection, transfusion and infusion of fluids or medications. The peripheral intravenous catheterization (PIVC) procedure is the introduction of a short catheter into a peripheral vein and can be problematic, leading to multiple failed
PMID 23442240

Characterization of local vascular effects of the nitric oxide inhibitor NG-monomethyl-L-arginine on dorsal hand veins.

Schindler C, Leuschner S, Schwanebeck U, Kirch W.Author information Institute of Clinical Pharmacology, Medical Faculty, Technical University Dresden, Fiedlerstrasse 27, D-01307 Dresden, Germany. christoph.schindler@tu-dresden.deAbstractInfusion of NG-monomethyl-L-arginine (L-NMMA; 6.4 µmol/min) into hand veins can cause a 20% increase in vein size in specific subjects. This study explored potential underlying mechanisms in healthy male participants. Ten healthy male participants received in phenylephrine (PE)-preconstricted veins a dose-response curve (DRC) to L-NMMA (0.2-6.4 µmol/min) without and with coinfusion of the endothelium-dependent dilator histamine, a DRC to L-arginine with and without coinfusion of L-NMMA, a DRC to NG-monomethyl-D-arginine (D-NMMA), and a DRC to L-NMMA in prostaglandin F(2α)-(PGF(2α))-preconstricted veins. Participants were classified as L-NMMA responders (R) and nonresponders (NR). Infusion of L-NMMA resulted in a maximum venodilation of 38% ± 11% (R) versus 10% ± 5% (NR; P = .005). In PGF(2α)-preconstricted veins, L-NMMA caused venodilation to 26% ± 34% (NS) in responders. Results suggest that endothelial nitric oxide synthase-mediated formation of nitric oxide (NO) from L-NMMA in doses >3.2 µmol/min and continuous PE-induced α-adrenergic stimulation resulting in release of very small amounts of NO from L-NMMA contribute to the observed L-NMMA-induced increase in vein size. Venous reactivity to L-NMMA resulting in a phenotype as R or NR is most likely genetically predetermined, which requires further study.
Journal of clinical pharmacology.J Clin Pharmacol.2012 Jun;52(6):859-69. doi: 10.1177/0091270011406277. Epub 2011 May 12.
Infusion of NG-monomethyl-L-arginine (L-NMMA; 6.4 µmol/min) into hand veins can cause a 20% increase in vein size in specific subjects. This study explored potential underlying mechanisms in healthy male participants. Ten healthy male participants received in phenylephrine (PE)-preconstricted veins
PMID 21566204

Japanese Journal

水中運動前の水分補給がその後の運動と生体反応に及ぼす影響について

矢野琢也,岡田昌義
体力科學 55(5), 461-467, 2006-10-01
… Body temperature was measured in the tympanic space and venodilation was measured in the fingers. …
NAID 110004821398

慢性心不全患者における強心薬 OPC-18790(Toborinone)の心血行動態および心筋エネルギー効率に及ぼす急性効果

神田裕文,横田充弘,祖父江俊和,石原均,永田浩三,井澤英夫
臨床薬理 27(4), 699-712, 1996-12-31
… In addition to venodilation, systemic vasodilation was observed after OPC-18790 infusion. …
NAID 10011506457