WordNet

of or involving the uterus; "uterine cancer"

PrepTutorEJDIC

子宮の / 同母異父の

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 妊娠性絨毛腫瘍：疫学、臨床的特徴、診断、病期分類、およびリスク層別化 gestational trophoblastic neoplasia epidemiology clinical features diagnosis staging and risk stratification
2. 女性における生殖器出血の鑑別診断 differential diagnosis of genital tract bleeding in women
3. 閉経後女性における子宮出血 postmenopausal uterine bleeding
4. 産後ケアの概要 overview of postpartum care
5. 胞状奇胎：マネージメント hydatidiform mole management

English Journal

Choriocarcinoma-like tumor in a potbellied pig (Sus scrofa).

Hirata A, Miyazaki A, Sakai H, Imada N, Kitani R, Nikami H, Yanai T.Author information Division of Animal Experiment, Life Science Research Center (Hirata, Nikami), Gifu University, Gifu, Japan.AbstractA uterine tumor, with histological and immunohistochemical features consistent with those of human choriocarcinoma, was identified in a 10-year-old unmated female pot-bellied pig (Sus scrofa). The tumor showed biphasic proliferation of cytotrophoblast-like cells and syncytiotrophoblast-like cells. Immunohistochemically, the syncytiotrophoblast-like cells were positive for human chorionic gonadotropin, and both types of cells were positive for cytokeratin and negative for vimentin, octamer-binding transcription factor 4, and α-fetoprotein. Because syncytiotrophoblasts are absent in the normal porcine placenta, the tumor was diagnosed as a choriocarcinoma-like tumor.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.J Vet Diagn Invest.2013 Dec 18. [Epub ahead of print]
A uterine tumor, with histological and immunohistochemical features consistent with those of human choriocarcinoma, was identified in a 10-year-old unmated female pot-bellied pig (Sus scrofa). The tumor showed biphasic proliferation of cytotrophoblast-like cells and syncytiotrophoblast-like cells. I
PMID 24352226

Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in vivo and the human trophoblast line BeWo in vitro.

Jones H1, Crombleholme T2, Habli M3.Author information 1The Center for Cellular and Molecular Fetal Therapy, Division of Pediatric General, Thoracic and Fetal Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: helen.jones@cchmc.org.2Colorado Fetal Care Center, Children's Hospital Colorado and The University of Colorado School of Medicine, Aurora, CO, USA.3The Center for Cellular and Molecular Fetal Therapy, Division of Pediatric General, Thoracic and Fetal Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.AbstractPrevious work in our laboratory demonstrated that over-expression of human insulin-like growth factor-11 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this effect have not been elucidated. To investigate the effect of intra-placental IGF-1 over-expression on placental function we examined amino acid transporter expression and localization in both a mouse model of placental Insufficiency (PI) and a model of human trophoblast, the BeWo Choriocarcinoma cell line. For in vitro human studies, BeWo Choriocarcinoma cells were maintained in F12 complete medium + 10%FBS. Cells were incubated in serum-free control media ± Ad-IGF-1 or Ad-LacZ for 48 h. MOIs of 10:1 and 100:1 were utilized. In BeWo, transfection efficiency was 100% at an MOI of 100:1 and Ad-IGF-1 significantly increased IGF-1 secretion, proliferation and invasion but reduced apoptosis compared to controls. In vitro, amino acid uptake was increased following Ad-IGF-1 treatment and associated with significantly increased RNA expression of SNAT1, 2, LAT1 and 4F2hc. Only SNAT2 protein expression was increased but LAT1 showed relocalization from a perinuclear location to the cytoplasm and cell membrane. For in vivo studies, timed-pregnant animals were divided into four groups on day 18; sham-operated controls, uterine artery branch ligation (UABL), UABL + Ad-hIGF-1 (108 PFU), UABL + Ad-LacZ (108 PFU). At gestational day 20, pups and placentas were harvested by C-section. Only LAT1 mRNA expression changed, showing that a reduced expression of the transporter levels in the PI model could be partially rectified with Ad-hIGF1 treatment. At the protein level, System L was reduced in PI but remained at control levels following Ad-hIGF1. The System A isoforms were differentially regulated with SNAT2 expression diminished but SNAT1 increased in PI and Ad-hIGF1 groups. Enhanced amino acid isoform transporter expression and relocalization to the membrane may be an important mechanism contributing to Ad-hIGF-1 mediated correction of placental insufficiency.
Placenta.Placenta.2013 Dec 6. pii: S0143-4004(13)00832-1. doi: 10.1016/j.placenta.2013.11.012. [Epub ahead of print]
Previous work in our laboratory demonstrated that over-expression of human insulin-like growth factor-11 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this
PMID 24360522

First confirmation by genotyping of transplacental choriocarcinoma transmission.

Bolze PA, Weber B, Fisher RA, Seckl MJ, Golfier F.Author information Department of Obstetrics and Gynecology, French Trophoblastic Disease Reference Center, Lyon Sud University Hospital, Lyon 1 Claude Bernard University, Pierre-Bénite, France.AbstractA mother developed multimetastatic gestational choriocarcinoma 13 months after delivery, and her infant died aged 11 months from the same tumor. The transplacental choriocarcinoma transmission was confirmed by genotyping. Henceforth, we recommend a 2-year maternal human chorionic gonadotropin follow-up after neonatal choriocarcinoma and extensive imaging if the human chorionic gonadotropin rises.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2013 Oct;209(4):e4-6. doi: 10.1016/j.ajog.2013.07.002. Epub 2013 Jul 11.
A mother developed multimetastatic gestational choriocarcinoma 13 months after delivery, and her infant died aged 11 months from the same tumor. The transplacental choriocarcinoma transmission was confirmed by genotyping. Henceforth, we recommend a 2-year maternal human chorionic gonadotropin follow
PMID 23850527

Japanese Journal

診断と効果判定に難渋し、止血のために2回の子宮動脈塞栓術を用いた臨床的侵入奇胎の1例

松﨑結花里,松永竜也,中島泉 [他]
神奈川産科婦人科学会誌 = Kanagawa journal of obstetrics and gynecology : official journal, Kanagawa Society of Obstetrics and Gynecology 50(2), 123-127, 2014-01
NAID 40020248927

Expression and Potential Role of GATA6 in Ruminant Trophoblasts during Peri-implantation Periods

Bai Hanako,Sakurai Toshihiro,Ideta Atsushi,Aoyagi Yoshito,Godkin James D.,Imakawa Kazuhiko
Journal of Mammalian Ova Research 29(3), 135-141, 2012
… In both cases, GATA6 mRNA increased on day 22 or 21 after conceptus attachment to the uterine epithelium. … In transient transfection analyses using the upstream region of the bovine IFNT gene (bIFNT, IFN-tau-c1), GATA6 overexpression was effective in the up-regulation of the bIFNT construct that had been transfected into human choriocarcinoma JEG3 or bovine ear-derived fibroblast EF cells. …
NAID 130004436842

Differential expression and the anti-apoptotic effect of human placental neurotrophins and their receptors.

Fujita K,Tatsumi K,Kondoh E,Chigusa Y,Mogami H,Fujii T,Yura S,Kakui K,Konishi I
Placenta 32(10), 737-744, 2011-10
… Here we investigated the correlation of NT and NTR in human placenta with uterine environment and fetal growth. … TrkB mRNA expression was up-regulated on cultured villous tissue explants and on JEG-3, a choriocarcinoma cell line, by H(2)O(2) treatment. …
NAID 120003477795