ウロ・ルフィリノーゲン
- 同
- uroporphyrinogens
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/12/30 10:47:55」(JST)
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Uroporphyrinogens are cyclic tetrapyrroles with four propionic acid groups ("P" groups) and four acetic acid groups ("A" groups).
There are four forms, which vary based upon the arrangements of the "P" and "A" groups (in clockwise order):
- In the "I" variety (i.e. uroporphyrinogen I), the order repeats four times: AP-AP-AP-AP.
- In the "III" variety (i.e. uroporphyrinogen III), the fourth is reversed: AP-AP-AP-PA.
- This is the most common form. In the synthesis of porphyrin, it is created from the linear tetrapyrrole hydroxymethylbilane by the enzyme uroporphyrinogen III synthase, and is further converted into coproporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase .
- The "II" and "IV" varieties can be created synthetically, but do not appear in nature.
External links
- Uroporphyrinogens at the US National Library of Medicine Medical Subject Headings (MeSH)
Types of tetrapyrroles
|
Bilanes
(Linear) |
- Bilirubin
- Biliverdin
- Stercobilinogen
- Stercobilin
- Urobilinogen
- Urobilin
|
Phytobilins |
|
Phycobilins |
- Phycoerythrobilin
- Phycocyanobilin
- Phycourobilin
- Phycoviolobilin
|
|
|
Macrocycle |
Corrinoids |
- Methylcobalamin
- Adenosylcobalamin
- Cyanocobalamin
|
Porphyrins |
Protoporphyrins |
- Protoporphyrin IX
- Heme (b, c, a, o)
- Zinc protoporphyrin
- Magnesium protoporphyrin
|
Phytoporphyrins |
- Chlorophyll c
- Protochlorophyllide
|
|
Reduced
porphyrins |
Porphyrinogens |
- Uroporphyrinogen (I, III)
- Coproporphyrinogen (I, III)
- Protoporphyrinogen IX
|
Chlorins |
- Chlorophyllide (a, b)
- Chlorophyll (a, b)
- Phaeophytin (a, b)
- Bacteriochlorophyll c
|
Bacteriochlorins |
|
Isobacteriochlorins |
- Siroheme
- Sirohydrochlorin
|
Corphins |
|
|
|
UpToDate Contents
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English Journal
- Identification of mutations in the uroporphyrinogen III synthase gene in a Thai girl patient with congenital erythropoietic porphyria.
- Glomglao W1, Treesucon A, Roothumnong E, Thongnoppakhun W, Siraprapapat P, Suwanthol L, Sanpakit K, Tanphaichitr VS.
- International journal of laboratory hematology.Int J Lab Hematol.2014 Aug 5. doi: 10.1111/ijlh.12282. [Epub ahead of print]
- PMID 25092523
- Recent advances in the biosynthesis of modified tetrapyrroles: the discovery of an alternative pathway for the formation of heme and heme d 1.
- Bali S1, Palmer DJ, Schroeder S, Ferguson SJ, Warren MJ.
- Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2014 Aug;71(15):2837-63. doi: 10.1007/s00018-014-1563-x. Epub 2014 Feb 11.
- Hemes (a, b, c, and o) and heme d 1 belong to the group of modified tetrapyrroles, which also includes chlorophylls, cobalamins, coenzyme F430, and siroheme. These compounds are found throughout all domains of life and are involved in a variety of essential biological processes ranging from photosyn
- PMID 24515122
- Coupled selection of protein solubility in E. coli using uroporphyrinogen III methyltransferase as red fluorescent reporter.
- Wang Z1, Yan H1, Li S1, Zhang K1, Cheng B1, Fan J2.
- Journal of biotechnology.J Biotechnol.2014 Jul 3. pii: S0168-1656(14)00316-2. doi: 10.1016/j.jbiotec.2014.06.025. [Epub ahead of print]
- Uroporphyrinogen III methyltransferase (UMT) is a novel reporter owing to the catalytic products accumulated in cells emitting red florescence. Overexpression of UMT confers resistance of the Escherichia coli cells to potassium tellurite that inhibits cell growth. In this study, we applied UMT repor
- PMID 24998762
Japanese Journal
- 色素関係 ウロポルフィリノーゲン脱炭酸酵素(UROD) (広範囲 血液・尿化学検査,免疫学的検査(第7版・1)その数値をどう読むか) -- (生化学的検査(1))
- Characterization of a Gene Conferring Red Fluorescence Isolated from an Environmental DNA Library Constructed from Soil Bacteria
- Bioscience, biotechnology, and biochemistry 72(7), 1908-1914, 2008-07-23
- NAID 10027530284
Related Links
- The UROD gene provides instructions for making an enzyme known as uroporphyrinogen decarboxylase. This enzyme is involved in the production of a molecule called heme. Heme is vital for all of the body's organs ...
- The UROS gene provides instructions for making an enzyme known as uroporphyrinogen III synthase. This enzyme is involved in the production of a molecule ... Fortian A, Castaño D, Ortega G, Laín A, Pons M, Millet O ...
Related Pictures
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ウロポルフィリノーゲン脱炭酸酵素 UROD
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ウロポルフィリノーゲンIII合成酵素
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ウロポルフィリノーゲンIII合成酵素