尿細胞診
WordNet
- of or relating to the urinary system of the body
- of or relating to the function or production or secretion of urine
- the branch of biology that studies the structure and function of cells
PrepTutorEJDIC
- 尿の;泌尿(ひにょう)[器]の
- 細胞学
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English Journal
- C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.
- Tang Y, Huang XR, Lv J1, Chung AC, Zhang Y2, Chen JZ1, Szalai AJ3, Xu A1, Lan HY.Author information 1*Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.2†Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.3§Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, U.S.A.AbstractCRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and urea levels (P<0.01) in patients with AKI, which then fell after recovery from AKI. To determine the role of CRP in AKI, an ischaemia/reperfusion mouse model of AKI was developed using Tg (transgenic) mice that express human CRP. Compared with the WT (wild-type) mice, CRP Tg mice developed more severe renal injury at 24 h after ischaemia as determined by significantly increased serum creatinine and tubular necrosis. This was associated with an impaired TEC (tubular epithelium cell) regeneration as shown by an over 60% reduction in PCNA+ (proliferating-cell nuclear antigen) and BrdU+ (bromodeoxyuridine) TECs in CRP Tg mice with AKI. In vitro, the addition of CRP to a human TEC line (HK-2) also largely suppressed the proliferation of TECs. The functional role of CRP in AKI was demonstrated further by the blocking of CRP binding to the FcγRII (Fcγ receptor II) with a neutralizing anti-CD32 antibody, which restored TEC proliferation and prevented AKI in CRP Tg mice. Moreover, we found that impaired G1/S transition by suppression of the phosphorylation of CDK2 (cyclin-dependent kinase 2) and expression of cyclin E may be a key mechanism by which CRP inhibits TEC regeneration during the AKI repair process. In conclusion, CRP plays a pathogenic role in AKI by inhibiting G1/S-dependent TEC regeneration. The results of the present study suggest that targeting CRP signalling may offer a new therapeutic potential for AKI.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 May;126(9):645-59. doi: 10.1042/CS20130471.
- CRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and u
- PMID 24206243
- In silico and in vivo studies of truncated forms of flagellin (FliC) of enteroaggregative Escherichia coli fused to FimH from uropathogenic Escherichia coli as a vaccine candidate against urinary tract infections.
- Savar NS1, Jahanian-Najafabadi A2, Mahdavi M3, Shokrgozar MA4, Jafari A1, Bouzari S5.Author information 1Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.2Department of Pharmaceutical Biotechnology, and Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran.3Department of Virology, Pasteur Institute of Iran, Tehran, Iran.4National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.5Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran. Electronic address: saeidbouzari@yahoo.com.AbstractThe new generation of vaccines against infectious diseases is based on recombinant fusion proteins. Flagellin (FliC) of enteroaggregative Escherichia coli (EAEC) could be considered as a potent adjuvant in designing new vaccines. However, because of its large size, incorporation of this protein with a vaccine antigen might negatively influence recognition of the vaccine epitopes by the immune system. Designing the truncated forms of FliC, capable of inducing innate immune response, enhances the immune responses to the target antigen. We have previously shown that two truncated forms of FliC are able to induce Interleukine-8 production in HT-29 epithelial cell line. In this study we designed recombinant vaccine against urinary tract infections (UTIs) using truncated forms of FliC and type 1 fimbrial FimH adhesin from uropathogenic Escherichia coli (UPEC) and studied their in silico interactions with Toll-like receptor 5 (TLR-5) via docking protocols. The best fusion protein was subjected to cloning and expression. The ability of the recombinant vaccine and the truncated forms in inducing immune responses was investigated. Our results showed that truncated forms are capable of inducing Th1 (forms A and B) and Th2 (form A) responses and fusion vaccine induced strong cellular and humoral immune responses.
- Journal of biotechnology.J Biotechnol.2014 Apr 10;175:31-7. doi: 10.1016/j.jbiotec.2014.01.037. Epub 2014 Feb 12.
- The new generation of vaccines against infectious diseases is based on recombinant fusion proteins. Flagellin (FliC) of enteroaggregative Escherichia coli (EAEC) could be considered as a potent adjuvant in designing new vaccines. However, because of its large size, incorporation of this protein with
- PMID 24530504
- Primary small cell carcinoma of the urinary bladder: a case report demonstrates cytological findings in SurePath liquid-based cytology.
- Ko H1, Park SY, Cha EJ, Sohn JS.
- Cytopathology : official journal of the British Society for Clinical Cytology.Cytopathology.2014 Apr;25(2):135-6. doi: 10.1111/cyt.12067. Epub 2013 May 19.
- PMID 23682948
Japanese Journal
- 脊髄髄膜瘤による神経因性膀胱患者に発症した膀胱扁平上皮癌の1例
- 前阪 郁賢,百瀬 均,中濵 智則,山田 篤,松本 吉弘
- 泌尿器科紀要 = Acta urologica Japonica 67(3), 103-107, 2021-03
- … Computerized tomography, urinary cytology and cystoscopy failed to reveal causative lesions and the hematuria ceased spontaneously. … Because gross hematuria recurred 2 years later, we examined the patient again and detected calcification of the urinary bladder. … Radical cystectomy and urinary diversion were performed and the histopathological diagnosis was pT3aN0. …
- NAID 120007033638
- 尿細胞診に胃型腺癌が出現した OHVIRA 症候群の 1 例
- 中澤 久美子,近藤 哲夫,大森 真紀子,望月 直子,花井 佑樹,笠井 一希,中村 海斗,田中 薫,大石 直輝,望月 邦夫
- 日本臨床細胞学会雑誌 60(2), 122-128, 2021
- <p><b>背景</b> : 尿細胞診で胃型形質を示す腺癌が認められたまれな症例を経験したので報告する. </p><p><b>症例</b> : 患者は 40 歳代, 女性. 膀胱腫瘍による尿管閉塞から急性腎不全となり救急搬送された. MRI で膀胱腫瘍と重複子宮, 重複腟, 片側腟閉鎖, 片側腎欠損 (OHVIRA …
- NAID 130008030944
- 小堺 智文,原 美紀子,岩本 拓朗,塚原 勝弘,山田 麻衣子,中林 徹雄,太田 浩良
- 医学検査 70(2), 362-367, 2021
- <p>前立腺癌細胞が尿や胸水細胞診中に出現することは稀であり，細胞診においては形態学的評価に加えて免疫染色の併用が診断に有用である。今回，尿と胸水細胞診中に腫瘍細胞を認めた前立腺癌の1例を報告する。70歳代男性。検診にて血清前立腺特異抗原（prostatic specific antigen; PSA）高値を指摘された。前立腺針生検では，明瞭な核小体を示す異型細胞が基底細胞層を欠いた小 …
- NAID 130008029851
Related Links
- Equivocal urinary cytology can be a diagnostic challenge. We have prepared an online gallery of 52 urinary cytologies including "atypical" specimens as well as some positive and negative controls. Each of the shown cell groups has ...
- Urinary Tract Cytology INTRODUCTION The urinary tract is composed of the kidneys, the ureters, urinary bladder and the urethra. The basal portion of the urinary bladder contains the trigone, a triangular area with the apex directed ...
★リンクテーブル★
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- 英
- urinary cytology
- 関
- 細胞診
- 主に尿路上皮癌の診断に用いられる尿中へ脱落した細胞の細胞診。細胞の種類、異型度を判定する
- 新鮮自排尿を遠沈後(尿沈渣)、巣態度硝子に付着させ、アルコール固定後パパニコロー染色
- 内視鏡的に隆起性病変がみられない上皮内癌に対して診断的意義が大きい。
- 核や核小体の増大・大小不同、核細胞質比(N/C比)の増加によりclass I～class Vに分類する
- class I ：陰性
- class II ：陰性
- class III ：疑陽性
- class IV ：陽性
- class VI ：陽性
膀胱癌(標準泌尿器科学 第8版)
- 異型度の高いガン細胞ほど細胞診陽性となる割合が高い
- G1：10%、G2：50%、G3：90% → したがって上皮内癌、筋層浸潤癌での陽性率が高い。
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- 関
- urinary organ、urinary tract、urine、uro