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Uridine diphosphate, abbreviated UDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside uridine. UDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase uracil.

UDP is an important factor in glycogenesis. Before glucose can be stored as glycogen in the liver and muscles, the enzyme UDP-glucose pyrophosphorylase forms a UDP-glucose unit by combining glucose 1-phosphate with uridine triphosphate, cleaving a pyrophosphate ion in the process. Then, the enzyme glycogen synthase combines UDP-glucose units to form a glycogen chain. The UDP molecule is cleaved from the glucose ring during this process and can be reused by UDP-glucose pyrophosphorylase.^[1]^[2]

References

^ Glycogen Biochemistry
^ Biochemistry Pathways: Polysaccharide Synthesis

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English Journal

Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes.

Fan YJ, Rong Y, Li PF, Dong WL, Zhang DY, Zhang L, Cui MJ.SourceSchool of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: swf89105@hfut.edu.cn.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2013 May;55:172-81. doi: 10.1016/j.fct.2013.01.003. Epub 2013 Jan 16.
The purpose of this study was to investigate genistein's influence on the relationship between the activation of uridine diphosphate glucuronosyltransferase (UGTs) and the protection against acetaminophen-induced liver toxicity. Animal experimental results revealed that genistein (50, 100 or 200mg/B
PMID 23333575

UGT1A1*28 is Associated with Decreased Systemic Exposure of Atorvastatin Lactone.

Stormo C, Bogsrud MP, Hermann M, Asberg A, Piehler AP, Retterstøl K, Kringen MK.SourceDepartment of Medical Biochemistry, Oslo University Hospital, University of Oslo, Nydalen, P.O. Box 4956, 0424, Oslo, Norway, camilla.stormo@medisin.uio.no.
Molecular diagnosis & therapy.Mol Diagn Ther.2013 Apr 12. [Epub ahead of print]
BACKGROUND: Atorvastatin is commonly used to reduce cholesterol. Atorvastatin acid is converted to its corresponding lactone form spontaneously or via glucuronidation mediated by uridine diphosphate glucuronosyltransferase (UGT) 1A1 and 1A3. Atorvastatin lactone is pharmacologically inactive, but is
PMID 23580084

RT-qPCR analysis of dexB and galE gene expression of Streptococcus alactolyticus in Astragalus membranaceus fermentation.

Hao GJ, Zhang K, Zhang JY, Wang XR, Qin Z, Wang XZ, Wang L, Meng JR, Yang ZQ, Li JX.SourceEngineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Key Lab of New Animal Drug Project of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutics Sciences of Chinese Academy of Agricultural Sciences, No. 335, Jiangouyan Street, Qilihe District, Lanzhou, 730050, Gansu Province, China.
Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2013 Apr 9. [Epub ahead of print]
Streptococcus alactolyticus strain FGM, isolated from chicken cecum, was used to increase the extract yield of polysaccharides during Astragalus membranaceus fermentation. It was previously demonstrated that polysaccharides from fermented A. membranaceus by S. alactolyticus had some similar properti
PMID 23563988

Japanese Journal

Human Hepatocarcinoma Functional Liver Cell-4 Cell Line Exhibits High Expression of Drug-Metabolizing Enzymes in Three-Dimensional Culture

Kato Ryuji,Shigemoto Kota,Akiyama Hiromasa [他]
Biological & pharmaceutical bulletin 37(11), 1782-1787, 2014-11
NAID 40020248089

Effect of Adrenalectomy on Expression and Induction of UDP-Glucuronosyltransferase 1A6 and 1A7 in Rats

Sakakibara Yukiko,Katoh Miki,Suzuki Masaya [他]
Biological & pharmaceutical bulletin 37(4), 618-624, 2014-04
NAID 40020030196

Influence of UGT1A1 *6, *27, and *28 Polymorphisms on Nilotinib-induced Hyperbilirubinemia in Japanese Patients with Chronic Myeloid Leukemia

, , , , , , ,
Drug Metabolism and Pharmacokinetics 29(6), 449-454, 2014
… Nilotinib potently inhibits human uridine diphosphate-glucuronosyltransferase (UGT1A1) activity, causing hyperbilirubinemia. …
NAID 130004933555

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★リンクテーブル★

リンク元	「UDP」「ウリジン二リン酸」
拡張検索	「uridine diphosphate glucose」「uridine diphosphate glucuronosyltransferase」「uridine diphosphate glucose pyrophosphorylase」「uridine diphosphate-glucuronate」「uridine diphosphate sugar」
関連記事	「diphosphate」

「UDP」

Uridine diphosphate
Names
	IUPAC name Uridine 5'-(trihydrogen diphosphate)
Identifiers
CAS Registry Number	58-98-0
ChEMBL	ChEMBL130266
ChemSpider	19952429
	InChI InChI=1S/C9H12N2O6.2H3O4P/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16;21-5(2,3)4/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16);2(H3,1,2,3,4)/t4-,6-,7-,8-;;/m1../s1 ; Key: PMPFLUWUGZHTOK-WFIJOQBCSA-N ;
IUPHAR ligand	1749
MeSH	Uridine+diphosphate
PubChem	1158
Properties
Chemical formula	C9H14N2O12P2
Molar mass	404.161
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references