undervirilization

undervirilization is a medical term describing the state of a male whose body, especially the genitalia, shows evidence of below-normal prenatal (less commonly pubertal) androgen effects.

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/22 16:36:51」(JST)

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1. アンドロゲン受容体障害の診断および治療 diagnosis and treatment of disorders of the androgen receptor
2. 外陰部異常を有する幼児の評価 evaluation of the infant with ambiguous genitalia
3. アンドロゲン受容体障害の病因および臨床症状 pathogenesis and clinical manifestations of disorders of androgen action
4. 副腎不全の稀な原因 unusual causes of adrenal insufficiency
5. 副腎アンドロゲン過剰症 adrenal hyperandrogenism

Different types of androgen receptor mutations in patients with complete androgen insensitivity syndrome.

Shao J1, Hou J1, Li B2, Li D1, Zhang N1, Wang X1.
Intractable & rare diseases research.Intractable Rare Dis Res.2015 Feb;4(1):54-9. doi: 10.5582/irdr.2014.01035.
Mutations of androgen receptor (AR) are the most frequent cause of 46, XY disorders of sex development and associated with a variety of phenotypes, ranging from phenotypic women (complete androgen insensitivity syndrome (CAIS)) to milder degrees of undervirilization (partial form or PAIS) or men wit
PMID 25674389

Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.

Riester A1, Reincke M2.
European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2015 Jan;172(1):R23-30. doi: 10.1530/EJE-14-0444. Epub 2014 Aug 27.
Primary aldosteronism (PA) is the most common cause of secondary hypertension. In this review, we discuss the diagnosis and management of PA during pregnancy based on the literature. As aldosterone and renin are physiologically increased during pregnancy and confirmation tests are not recommended, t
PMID 25163723

Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies.

Bouchoucha N1, Samara-Boustani D2, Pandey AV1, Bony-Trifunovic H3, Hofer G1, Aigrain Y4, Polak M2, Flück CE5.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jun 5;390(1-2):8-17. doi: 10.1016/j.mce.2014.03.008. Epub 2014 Apr 4.
BACKGROUND: P450 aromatase (CYP19A1) is essential for the biosynthesis of estrogens from androgen precursors. Mutations in the coding region of CYP19A1 lead to autosomal recessive aromatase deficiency. To date over 20 subjects have been reported with aromatase deficiency which may manifest during fe
PMID 24705274