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Xie J1, He G1,2, Chen Q1, Sun J3, Dai Q1, Lu J1, Li G1, Wu H1, Li R1, Chen J1, Xu W1, Xu B1.
Molecular medicine (Cambridge, Mass.).Mol Med.2016 Jan 21. doi: 10.2119/molmed.2015.00026. [Epub ahead of print]
Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimulus such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimulus such as hypertension and aortic valvular stenosis cause maladaptive cardiac remodeling an
PMID 26835698

β3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation.

Dong J1, Zhao J1, Zhang M1, Liu G1, Wang X1, Liu Y1, Yang N2, Liu Y3, Zhao G1, Sun J1, Tian J1, Cheng C4, Wei L5, Li Y1, Li W6.
Journal of cardiovascular pharmacology and therapeutics.J Cardiovasc Pharmacol Ther.2016 Jan;21(1):114-26. doi: 10.1177/1074248415590440. Epub 2015 Jun 30.
BACKGROUND: The β3-adrenoceptor (β3-AR) is implicated in cardiac remodeling. Since metabolic dysfunction due to loss of mitochondria plays an important role in heart diseases, we examined the effects of β3-AR on mitochondrial biogenesis and energy metabolism in atrial fibrillation (AF).METHODS: A
PMID 26130614

A Novel Inherited Mutation in PRKAR1A Abrogates PreRNA Splicing in a Carney Complex Family.

Sun Y1, Chen X2, Sun J3, Wen X3, Liu X4, Zhang Y5, Hoffman AR6, Hu JF7, Gao Y8.
The Canadian journal of cardiology.Can J Cardiol.2015 Nov;31(11):1393-401. doi: 10.1016/j.cjca.2015.05.018. Epub 2015 May 30.
BACKGROUND: Carney complex (CNC) is an autosomal dominant inherited disease, characterized by spotty skin pigmentation, cardiac and cutaneous myxomas, and endocrine overactivity. We report on a Chinese CNC family with a novel mutation in the protein kinase A regulatory subunit 1 (PRKAR1A) gene.METHO
PMID 26416542

Characterization, Risk Stratification and the Hypertension Control Rate at Hospital-based Clinics: A Survey of 25,336 Hypertensives in Beijing, Shanghai and Guangzhou