WordNet

furthest or highest in degree or order; utmost or extreme; "the ultimate achievement"; "the ultimate question"; "mans ultimate destiny"; "the ultimate insult"; "ones ultimate goal in life"
the finest or most superior quality of its kind; "the ultimate in luxury"
being the last or concluding element of a series; "the ultimate sonata of that opus"; "a distinction between the verb and noun senses of `conflict is that in the verb the stress is on the ultimate (or last) syllable"
any agent (physical or environmental) that can induce a genetic mutation or can increase the rate of mutation
the last syllable in a word

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results.

Uno Y1, Kojima H2, Omori T3, Corvi R4, Honma M2, Schechtman LM5, Tice RR6, Beevers C7, Boeck MD8, Burlinson B9, Hobbs CA10, Kitamoto S11, Kraynak AR12, McNamee J13, Nakagawa Y14, Pant K15, Plappert-Helbig U16, Priestley C17, Takasawa H18, Wada K19, Wirnitzer U20, Asano N21, Escobar PA22, Lovell D23, Morita T2, Nakajima M24, Ohno Y2, Hayashi M25.
Mutation research. Genetic toxicology and environmental mutagenesis.Mutat Res Genet Toxicol Environ Mutagen.2015 Jul;786-788:45-76. doi: 10.1016/j.mrgentox.2015.04.010. Epub 2015 Apr 29.
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperatio
PMID 26212295

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

Uno Y1, Kojima H2, Omori T3, Corvi R4, Honma M2, Schechtman LM5, Tice RR6, Burlinson B7, Escobar PA8, Kraynak AR9, Nakagawa Y10, Nakajima M11, Pant K12, Asano N13, Lovell D14, Morita T2, Ohno Y2, Hayashi M15.
Mutation research. Genetic toxicology and environmental mutagenesis.Mutat Res Genet Toxicol Environ Mutagen.2015 Jul;786-788:3-13. doi: 10.1016/j.mrgentox.2015.04.011. Epub 2015 May 5.
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperatio
PMID 26212293

Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations.

Al-Subeihi AA1, Alhusainy W2, Kiwamoto R2, Spenkelink B2, van Bladeren PJ3, Rietjens IM2, Punt A2.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2015 Mar 1;283(2):117-26. doi: 10.1016/j.taap.2014.12.009. Epub 2014 Dec 27.
The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into account using Monte Carlo simulations. Depending on the
PMID 25549870

Activation Mechanism of 2-Acetylamino-9-fluroenone as a Mutagen in Salmonella typhimurium

Inami Keiko,Mochizuki Masataka
Genes and environment : the official journal of the Japanese Environmental Mutagen
… In this study, we investigated possible ultimate species derived from AAF=O; … Furthermore we suggest that an ultimate active species of AAF=O in S. …
NAID 110006873843

Activation Mechanism of 2-Acetylamino-9-fluorenone as a Mutagen in Salmonella typhimurium

,
Genes and Environment 30(3), 71-76, 2008
… In this study, we investigated possible ultimate species derived from AAF=O; … Furthermore we suggest that an ultimate active species of AAF=O in S. …
NAID 130004943586

Analysis of the Major RNA Adduct Derived from Aminophenylnorharman, a Novel Endogenous Mutagen and Carcinogen

Totsuka Yukari,Nishigaki Rena,Takamura-Enya Takeji [他],Kawahara Nobuo,Sugimura Takashi,Wakabayash Keiji
環境変異原研究 = Genes and environment : the official journal of the Japanese Environmental Mutagen
… When a reaction mixture of an ultimate mutagenic form of APIMH, N-acetoxy-APIMH, and guanosine (Guo) was subjected to LC-ESI/MS analysis, one peak, with a similar UV spectrum to dGuo-C8-APIMH, exhibited a molecular ion peak at m/z 541 along with a fragment peak at m/z 409, consistent with loss of a ribose moiety. …
NAID 110006279219