WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
either of two parallels of latitude about 23.5 degrees to the north and south of the equator representing the points farthest north and south at which the sun can shine directly overhead and constituting the boundaries of the Torrid Zone or tropics

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
〈C〉回帰線 / 《the tropics》熱帯地方 / 熱帯[地方]の(tropical)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/18 21:31:53」(JST)

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Tropic acid is a chemical with IUPAC name 3-hydroxy-2-phenylpropanoic acid and condensed structural formula HOCH₂CHPhCOOH. It is a laboratory reagent used in the chemical synthesis of atropine and hyoscyamine. Tropic acid is a chiral substance, existing as either a racemic mixture or as a single enantiomer.

Synthesis

Tropic acid synthesis 1:^[1]	Tropic acid synthesis 2:^[1]

Prepn:^[2]^[3]^[4]

Pharmaceutical Uses

Tropic acid is reacted with tropine (product of tropinone) to produce atropine (cf. Homatropine).
Scopine is reacted with tropic acid in a Fischer esterification to produce scopolamine also.
Other examples: tropicamide, Anisodamine.
Quats: Hyoscine butylbromide, Butropium bromide (Coliopan®), Fentonium, Methylatropine, methscopolamine.

References

^ ^a ^b PMID 12365608 (PubMed)
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^ Sletzinger, Paulsen, U.S. Patent 2,390,278 (1945 to Merck & Co.).
^ Blicke, U.S. Patent 2,716,650 (1955 to University of Michigan).
^ DE 923426 (1955 to Sterling Drug).

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UpToDate Contents

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2. 出産時の臍帯血酸塩基分析 umbilical cord blood acid base analysis at delivery
3. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
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English Journal

Rapid resolution liquid chromatography for monitoring the quality of stockpiled atropine preparations for injection.

Zimmermann T, Dimmel A, Jüttemeyer S, Springer D, Loch M.SourceCentral Institute of the Bundeswehr Medical Service Munich, Ingolstaedter Landstrasse 102, Garching Hochbrück, Germany. thomas2zimmermann@bundeswehr.org
Drug testing and analysis.Drug Test Anal.2012 Mar-Apr;4(3-4):222-8. doi: 10.1002/dta.402.
We describe a rapid resolution liquid chromatography (RRLC) method for analyzing atropine sulfate, its degradation products (tropic acid, apoatropine, atropic acid) and other components (e.g. phenol, methylparaben) in injectable medicines that are used by the German armed forces in emergency situati
PMID 22467254

High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma.

John H, Eyer F, Zilker T, Thiermann H.SourceBundeswehr Institute of Pharmacology and Toxicology, Department of Analytical Chemistry, Neuherbergstrasse 11, 80937 Munich, Bavaria, Germany. HaraldJohn@bundeswehr.org
Analytica chimica acta.Anal Chim Acta.2010 Nov 8;680(1-2):32-40. doi: 10.1016/j.aca.2010.09.018. Epub 2010 Sep 21.
S-hyoscyamine (S-hyo) is a toxic tropane alkaloid from plants of the solanacea family, which is extracted for pharmaceutical purposes thereby undergoing racemization (atropine). Merely the S-hyo enantiomer acts as an antagonist of muscarinic receptors (MR). Nevertheless, racemic atropine is clinical
PMID 20969988

Determination of hydroxyurea in serum or plasma using gas chromatography-mass spectrometry (GC-MS).

Scott DK, Neville K, Garg U.SourceDepartment of Pathology and Laboratory Medicine, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2010;603:279-87. doi: 10.1007/978-1-60761-459-3_26.
Hydroxyurea is an antineoplastic drug, which is also widely used in the treatment of sickle cell disease. Various methods including colorimetry, high performance liquid chromatography, and gas chromatography-mass spectrometry (GC-MS) are available for the assay of hydroxyurea. In the gas chromatogra
PMID 20077079

Japanese Journal

Transcriptional regulation of genes related to progesterone production [Review]

Mizutani Tetsuya,Ishikane Shin,Kawabe Shinya,Umezawa Akihiro,Miyamoto Kaoru
Endocrine Journal advpub(0), 2015
… 5-Aminolevulinic acid synthase 1, ferredoxin 1, and ferredoxin reductase also play a role in steroidogenesis as accessory factors. …
NAID 130005085779

Light-dependent gravitropism and negative phototropism of inflorescence stems in a dominant Aux/IAA mutant of Arabidopsis thaliana, axr2

Sato Atsuko,Sasaki Shu,Matsuzaki Jun,Yamamoto Kotaro T.
Journal of Plant Research 127(5), 627-639, 2014-09-01
… Application of 1-naphthaleneacetic acid-containing lanolin to the stem tips enhanced the positive phototropism of WT, and reduced the negative phototropism of axr2. … Tropic responses of the transgenic lines that expressed axr2-1 protein by the endodermis-specific promoter suggest that AXR2-dependent auxin response in the endodermis plays a more crucial role in gravitropism than in phototropism in stems but no significant roles in either tropism in hypocotyls. …
NAID 120005649116

CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit

Kamiyama Haruka,Kakoki Katsura,Shigematsu Sayuri,Izumida Mai,Yashima Yuka,Tanaka Yuetsu,Hayashi Hideki,Matsuyama Toshifumi,Sato Hironori,Yamamoto Naoki,Sano Tetsuro,Shidoji Yoshihiro,Kubo Yoshinao
AIDS Research and Human Retroviruses 29(2), 279-288, 2013-01-21
… In this study, we found that the acyclic retinoid analogs geranylgeranoic acid (GGA) and NIK-333 as well as CT-B efficiently attenuate CXCR4-tropic, but not CCR5-tropic, HIV-1 vector infection. … We also found that GGA and NIK-333 suppress CXCR4-tropic HIV-1 infection by attenuating CXCR4 expression. … CT-B also attenuated CXCR4-tropic HIV-1 infection, but did not suppress CXCR4 expression. …
NAID 120005230843

★リンクテーブル★

リンク元	「トロパ酸」「トロピン酸」
関連記事	「tropic」

「トロパ酸」

Tropic acid
Names
	IUPAC name 3-Hydroxy-2-phenylpropanoic acid
	Other names 2-Phenylhydracrylic acid; Tropate
Identifiers
CAS Registry Number	529-64-6
ChEBI	CHEBI:CHEBI:30765
ChemSpider	10274
EC number	209-020-6
	InChI InChI=1S/C9H10O3/c10-6-8(9(11)12)7-4-2-1-3-5-7/h1-5,8,10H,6H2,(H,11,12) ; Key: JACRWUWPXAESPB-UHFFFAOYSA-N ; InChI=1/C9H10O3/c10-6-8(9(11)12)7-4-2-1-3-5-7/h1-5,8,10H,6H2,(H,11,12); Key: JACRWUWPXAESPB-UHFFFAOYAV ;
Jmol-3D images	Image
KEGG	C01456
MeSH	C011377
PubChem	10726
	SMILES C1=CC=C(C=C1)C(CO)C(=O)O ;
Properties
Chemical formula	C9H10O3
Molar mass	166.18 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references