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street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

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酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/28 04:32:25」(JST)

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Trinitrobenzenesulfonic acid (C₆H₃N₃O₉S) is an nitroaryl oxidizing acid. Due to its extreme oxidative properties, if mixed with reducing agents including hydrides, sulfides, and nitrides, it may begin a vigorous reaction that culminates in almost immediate detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents because of the explosive tendencies of aromatic nitro compounds which increase in the presence of multiple nitro groups. Not much is known about this compound, but it is used as a peptide terminal amino group neutralizer and is currently being investigated for its effects on the immune system.^[1]

Uses

Its primary usage is primarily to neutralize peptide terminal amino groups in scientific research.^[2] Occasionally it is used as a detonator for certain other explosive compounds.

It is also used to induce ulcerative colitis in the large intestine and colon in order to model inflammatory bowel disease.^[3]

Health concerns and safety precautions

The primary hazard of working with 2,4,6-trinitrobenzenesulfonic acid is the risk of instantaneous explosion. 2,4,6-Trinitrobenzenesulfonic acid is an extremely sensitive compound especially when mixed with other compounds, exposed to heat, or exposed to rapid temperature or pressure changes. The toxicological properties of this compound has not been investigated, so all health effects are unknown. To best prevent bodily harm or injury its recommended that all direct contact be avoided and the compound be kept under extremely strict environmentally controlled conditions. In case of spillage its recommended that a local fire department be called in advance prior to any attempt at cleaning. In case of fire its recommended that the material is left to burn and the surrounding area is evacuated. If fire fighting is required its recommended that a fully positive pressure self-contained breathing apparatus is used along with either foam or CO₂ extinguishers.^[4]^[5]

References

^ Atsushi Kitani, Ivan J. Fuss, Kazuhiko Nakamura, Owen M. Schwartz, Takashi Usui, and Warren Strober (2000). "Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (Tgf)-β1 Plasmid: TGF-β1–Mediated Suppression of T Helper Cell Type 1 Response Occurs by Interleukin (Il)-10 Induction and IL-12 Receptor β2 Chain Downregulation". The Journal of Experimental Medicine 192 (1): 41–52. doi:10.1084/jem.192.1.41. PMC 1887715. PMID 10880525.
^ Trinitrobenzenesulfonic Acid, Comparative Toxicogenomics Database.
^ Scheiffele, F; Fuss, IJ (2002). "Induction of TNBS colitis in mice". Current Protocols in Immunology. Chapter 15: Unit 15.19. doi:10.1002/0471142735.im1519s49. ISBN 0471142735. PMID 18432874.
^ MSDS, chemcas.com.
^ savety, cameochemicals.

UpToDate Contents

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1. 胎児の酸塩基の生理学 fetal acid base physiology
2. 神経管欠損予防のための葉酸 folic acid for prevention of neural tube defects
3. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention
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English Journal

Chlorogenic acid-mediated gel formation of oxidatively stressed myofibrillar protein.

Cao Y1, Xiong YL2.
Food chemistry.Food Chem.2015 Aug 1;180:235-43. doi: 10.1016/j.foodchem.2015.02.036. Epub 2015 Feb 14.
The effect of chlorogenic acid (CA) at different concentration levels (0, 6, 30, and 150 μmol/g protein) on porcine myofibrillar protein (MP) gelling potential in relation to chemical and structural changes was investigated. The results showed that CA generally inhibited protein carbonyl formation
PMID 25766823

Inhibitory effects of SKI3246, the rhizome extract of Atractylodes japonica, on visceral hypersensitivity in experimental irritable bowel syndrome rat models.

Son HJ1, Jung K, Park YH, Jeon HJ, Kang M, Ryu KH, Pyo SS, Eutamene H, Bueno L, Sun WS.
Archives of pharmacal research.Arch Pharm Res.2015 May;38(5):642-9. doi: 10.1007/s12272-014-0454-x. Epub 2014 Jul 30.
We evaluated the effect of SKI3246, the 50 % ethanol extract of the rhizome of Atractylodes japonica, on visceral hypersensitivity, which is a major characteristic feature of IBS. We used various rat models of visceral hypersensitivity to assess the visceral pain responses to colorectal distension
PMID 25070763

A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii.

Garrido-Mesa J1, Algieri F1, Rodriguez-Nogales A1, Utrilla MP1, Rodriguez-Cabezas ME1, Zarzuelo A1, Ocete MA1, Garrido-Mesa N2, Galvez J3.
Pharmacological research : the official journal of the Italian Pharmacological Society.Pharmacol Res.2015 Apr 23;97:48-63. doi: 10.1016/j.phrs.2015.04.005. [Epub ahead of print]
Immunomodulatory antibiotics have been proposed for the treatment of multifactorial conditions such as inflammatory bowel disease. Probiotics are able to attenuate intestinal inflammation, being considered as safe when chronically administered. The aim of the study was to evaluate the anti-inflammat
PMID 25917208

Japanese Journal

トリニトロベンゼンスルホン酸誘発腸炎モデルラットにおける細胞内菌体成分認識分子Card15/Nod2の発現変化(解剖学)

藤澤正彦,清末正晴,堀正敏,尾崎博
The journal of veterinary medical science 68(7), 701-708, 2006-07-25
最近,難治性炎症性腸疾患であるCrohn病(CD)患者の遺伝学的連鎖解析により,その原因遺伝子の一つとしてCard15/Nod2が同定された.Card15/Nod2はLPS受容体であるTLR4と同様にLRR部位を含むことから,細胞内における菌体成分認識分子として注目され,自然免疫とIBDの関連性が示唆されている.しかし,腸炎疾患において実際にCard15/Nod2が粘膜層や筋層でどのような動態を示 …
NAID 110004763179

Identification of Card15/Nod2 mRNA in Intestinal Tissue of Experimentally Induced Colitis in Rats

FUJISAWA Masahiko,KIYOSUE Masaharu,HORI Masatoshi,OZAKI Hiroshi
Journal of Veterinary Medical Science 68(7), 701-708, 2006
… In this study, we examined the kinetics of Card15/Nod2 expression in intestinal tissue during inflammation in the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-treated rat experimental colitis model. …
NAID 130000447758

「TNBS」

2,4,6-Trinitrobenzene Sulfonic Acid
Names
	IUPAC name 2,4,6-Trinitrobenzenesulfonic acid
	Other names Picrylsulfonic acid; Trinitrobenzene sulfonate; TNBS
Identifiers
CAS Registry Number	2508-19-2
ChEBI	CHEBI:53063
ChemSpider	10577
	InChI InChI=1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18) ; Key: NHJVRSWLHSJWIN-UHFFFAOYSA-N ; InChI=1/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18); Key: NHJVRSWLHSJWIN-UHFFFAOYAG ;
Jmol-3D images	Image
	SMILES O=S(=O)(O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O ;
UN number	0386
Properties
Chemical formula	C6H3N3O9S
Molar mass	293.16 g·mol−1
Density	0.955 g/cm3
Hazards
R-phrases	R11 R36/38
S-phrases	S16 S26 S33 S37/39
NFPA 704	4 2 4 OX
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

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同: trinitrobenzenesulfonic acid

同: trinitrobenzenesulfonic acid

[1] Atsushi Kitani, Ivan J. Fuss, Kazuhiko Nakamura, Owen M. Schwartz, Takashi Usui, and Warren Strober (2000). "Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (Tgf)-β1 Plasmid: TGF-β1–Mediated Suppression of T Helper Cell Type 1 Response Occurs by Interleukin (Il)-10 Induction and IL-12 Receptor β2 Chain Downregulation". The Journal of Experimental Medicine 192 (1): 41–52. doi:10.1084/jem.192.1.41. PMC 1887715. PMID 10880525.

[2] Trinitrobenzenesulfonic Acid, Comparative Toxicogenomics Database.

[3] Scheiffele, F; Fuss, IJ (2002). "Induction of TNBS colitis in mice". Current Protocols in Immunology. Chapter 15: Unit 15.19. doi:10.1002/0471142735.im1519s49. ISBN 0471142735. PMID 18432874.

[4] MSDS, chemcas.com.

[5] savety, cameochemicals.

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trinitrobenzenesulfonic acid