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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/29 23:44:59」(JST)

English Journal

Solution structure of human P1*P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome.

Lee KM, Yusa K, Chu LO, Yu CW, Oono M, Miyoshi T, Ito K, Shaw PC, Wong KB, Uchiumi T.SourceSchool of Life Sciences, Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, Hong Kong, China and Department of Biology, Faculty of Science, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181, Japan.
Nucleic acids research.Nucleic Acids Res.2013 Oct 1;41(18):8776-87. doi: 10.1093/nar/gkt636. Epub 2013 Jul 26.
Lateral ribosomal stalk is responsible for binding and recruiting translation factors during protein synthesis. The eukaryotic stalk consists of one P0 protein with two copies of P1•P2 heterodimers to form a P0(P1•P2)2 pentameric P-complex. Here, we have solved the structure of full-length P1•
PMID 23892290

Effect of trichosanthin on apoptosis and telomerase activity of nasopharyngeal carcinomas in nude mice.

Kang M, Ou H, Wang R, Liu W, Mao Y, Tang A.SourceDepartment of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.J BUON.2013 Jul-Sep;18(3):675-82.
Purpose: To evaluate the effect of trichosanthin (TCS) on telomerase activity and apoptosis in nasopharyngeal carcinoma cells implanted into nude mice. Methods: Nude mice implanted with CNE1 and CNE2 nasopharyngeal carcinoma cell lines were randomly divided into 3 groups, including TCS group, contro
PMID 24065482

Wang P, Huang S, Wang F, Ren Y, Hehir M, Wang X, Cai J.SourceZhejiang Provincial Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, China. pinoav@hotmail.com
PloS one.PLoS One.2013 Jun 28;8(6):e65661. doi: 10.1371/journal.pone.0065661. Print 2013.
Recently, we have demonstrated that trichosanthin (TCS), a promising agent for the treatment of cervical adenocarcinoma, inhibited HeLa cell proliferation through the PKC/MAPK/CREB signal pathway. Furthermore, TCS down-regulated Bcl-2 expression was abrogated by a decoy oligonucleotide (OGN) to the
PMID 23840351

Two Novel Proteins Bind Specifically to Trichosanthin on Choriocarcinoma Cell Membrane

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors