・酸トリアムシノロン、二・酸トリアムシノロン

関: triamcinolone、triamcinolone hexacetonide

WordNet

a synthetic corticosteroid (trade names Aristocort or Aristopak or Kenalog) used as an anti-inflammatory agent (同)Aristocort, Aristopak, Kenalog

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/05 18:35:26」(JST)

wiki en

Triamcinolone is an intermediate-acting synthetic glucocorticoid given orally, by injection, by inhalation, or as a topical ointment or cream.^[1]

Uses

Triamcinolone is used to treat a number of different medical conditions, such as eczema, Lichen sclerosus, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, Urushiol-induced contact dermatitis, aphthous ulcers (usually as triamcinolone acetonide), visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.^[2]^[3]^[4] It has also been used off-label for macular degeneration.^[5]

Prior to 2007 it was sold under the name Azmacort as a corticosteroid inhaler for asthma long-term care.

In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.^[6]

Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.

The derivative triamcinolone acetonide is one of the ingredients of Ledermix, an endodontic (tooth's root canal) lotion used between sessions, and Sanofi sold it under the brand name Nasacort. Triamcinolone acetonide is also used as intra lesional steroid injection to treat keloids and hypertrophic scars.

According to Chang et al (2014), "Triamcinolone acetonide (TA) is classified as an S9 glucocorticoid in the 2014 Prohibited List published by the World Anti-Doping Agency, which caused it to be prohibited in-competition when administered orally, intravenously, intramuscularly or rectally".^[7]

Forms

Different triamcinolone derivatives are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects

Side effects of triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose.^{[citation needed]} White patches in the throat or nose indicate a serious side effect.^{[clarification needed]} Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.^[8] An additional side effect for women is a prolonged menstrual cycle.

Chemistry

Triamcinolone is a synthetic pregnane corticosteroid and derivative of cortisol (hydrocortisone) and is also known as 1-dehydro-9α-fluoro-16α-hydroxyhydrocortisone or 9α-fluoro-16α-hydroxyprednisolone as well as 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione.^[9]^[10]

Society and culture

Brand names

Trade names for triamcinolone include Aristocort (Sandoz, now Novartis), Kenacort (Bristol-Myers Squibb), Kenalog (Bristol-Myers Squibb), Tricort (Cadila), Triaderm (Schering-Plough), Azmacort (KOS), Trilone, Volon A, Tristoject, Tricortone, Ratio-Triacomb, and Trianex.

References

Aristocort (triamcinolone) topical cream

Kenalog (triamcinolone) IM injection

^ Chrousos G, Pavlaki AN, Magiakou MA (2011). "Glucocorticoid Therapy and Adrenal Suppression". PMID 25905379.
^ Triamcinolone - Drugs.com
^ Triamcinolone Inhalation - Drugs.com
^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
^ Age-Related Macular Degeneration (AMD) Treatment
^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
^ Chang, Chih-Wei; Huang, Tai-Yuan; Tseng, Yi-Chun; Chang-Chien, Guo-Ping; Lin, Su-Fan; Hsu, Mei-Chich (2014). "Positive doping results caused by the single-dose local injection of triamcinolone acetonide". Forensic Science International. 244: 1–6. doi:10.1016/j.forsciint.2014.07.024. PMID 25126738.
^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. Retrieved 2008-03-24.
^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1228–. ISBN 978-1-4757-2085-3.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1054–. ISBN 978-3-88763-075-1.

External links

Triamcinolone Topical | MedlinePlus
Triamcinolone (Topical Application Route) | MayoClinic

UpToDate Contents

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1. 病巣内注入 intralesional injection
2. 皮膚疾患の治療および外用ステロイドの一般原則 general principles of dermatologic therapy and topical corticosteroid use
3. 関節内および軟部組織注射：注射剤の種類および投与頻度 intraarticular and soft tissue injections what agents to inject and how frequently
4. 成人における関節吸引または注射：手技および適応 joint aspiration or injection in adults technique and indications
5. 網膜静脈閉塞：治療 retinal vein occlusion treatment

English Journal

Adult hypophosphatasia with painful periarticular calcification treated with surgical resection.

Iida K1, Fukushi J, Fujiwara T, Oda Y, Iwamoto Y.
Journal of bone and mineral metabolism.J Bone Miner Metab.2012 Nov;30(6):722-5. doi: 10.1007/s00774-011-0338-9. Epub 2011 Dec 15.
Hypophosphatasia is a rare inherited disorder characterized by a low serum alkaline phosphatase (ALP) activity and defective bone mineralization. Adult hypophosphatasia typically manifests in middle-age as a result of osteomalacia with recurrent stress fractures of the lower limb. However, considera
PMID 22167380

[Intralesional corticosteroid therapy in infantile hemangiomas].

Gawrych E1, Walecka A, Rajewska J, Juszkiewicz P.
Annales Academiae Medicae Stetinensis.Ann Acad Med Stetin.2009;55(1):15-21.
INTRODUCTION: This study was undertaken to evaluate the effectiveness of intralesional corticosteroid therapy in infantile hemangiomas.MATERIAL AND METHODS: The study was done in 38 patients aged 1 month to 14 years with infants accounting for 84% of all patients. Physical investigation was carried
PMID 20349587

[A comparative clinical study of the treatment of hypertrophic scars with either intralaesional steroid or silicone gel sheeting].

Kelemen O1, Kollár L, Menyhei G.
Magyar sebészet.Magy Seb.2007 Dec;60(6):297-300.
The linear (or "surgical") hypertrophic scar is the most common type of pathologic scarring. There has been a steady increase in the number of patients with hypertrophic scars over the years due to the rising number of operative interventions altogether. However, the therapeutic protocols are not ho
PMID 18065368

Japanese Journal

か牛窓膜透過性に関する実験的研究　第２報　　中耳内蛋白濃度の影響について:中耳内蛋白濃度の影響について

日本耳鼻咽喉科学会会報 91(11), 1864-1870, 1988
NAID 130000808485

関節内投与ステロイド剤ＴＨＳ‐２０１の抗炎症作用に関する研究

日本薬理学雑誌 87(1), 89-97, 1986
NAID 130000760473

Triamcinolone Diacetate局所注射液による2,3の皮膚疾患の治療

西日本皮膚科 40(4), p712-717, 1978-08
NAID 40002795164

「酢酸トリアムシノロン」

Triamcinolone
Clinical data
Trade names	Kenalog Nasacort
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: A; US: C (Risk not ruled out); ;
Routes of; administration	Oral, topical, IM, intra-articular, intrasynovial
ATC code	A01AC01 (WHO) C05AA12 (WHO), D07AB09 (WHO), H02AB08 (WHO), R01AD11 (WHO), R03BA06 (WHO), S01BA05 (WHO);
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only OTC (Nasacort, Intranasal);
Pharmacokinetic data
Protein binding	68%
Metabolism	Hepatic
Biological half-life	88 minutes
Excretion	Fecal and renal
Identifiers
	IUPAC name (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;
Synonyms	Click show to see (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number	124-94-7 ;
PubChem CID	31307;
IUPHAR/BPS	2870;
DrugBank	DB00620 ;
ChemSpider	29046 ;
UNII	1ZK20VI6TY;
KEGG	D00385 ;
ChEBI	CHEBI:9667 ;
ChEMBL	CHEMBL1451 ;
ECHA InfoCard	100.004.290
Chemical and physical data
Formula	C21H27FO6
Molar mass	394.434 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3O)C)C ;
	InChI InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1 ; Key:GFNANZIMVAIWHM-OBYCQNJPSA-N ;
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　　[★]

英: triamcinolone diacetate
関: トリアムシノロン、二・酸トリアムシノロン

「triamcinolone hexacetonide」

　　[★]

トリアムシノロンヘキサセトニド

関: triamcinolone、triamcinolone diacetate

「二酢酸トリアムシノロン」

　　[★]

英: triamcinolone diacetate
関: トリアムシノロン、・酸トリアムシノロン

「diacetate」

　　[★]

二酢酸塩、二酢酸エステル、二酢酸、ジアセテート

「triamcinolone」

　　[★] トリアムシノロン　

[ChrousosPavlaki2000-1] Chrousos G, Pavlaki AN, Magiakou MA (2011). "Glucocorticoid Therapy and Adrenal Suppression". PMID 25905379.

[2] Triamcinolone - Drugs.com

[3] Triamcinolone Inhalation - Drugs.com

[4] Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com

[5] Age-Related Macular Degeneration (AMD) Treatment

[6] Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit

[7] Chang, Chih-Wei; Huang, Tai-Yuan; Tseng, Yi-Chun; Chang-Chien, Guo-Ping; Lin, Su-Fan; Hsu, Mei-Chich (2014). "Positive doping results caused by the single-dose local injection of triamcinolone acetonide". Forensic Science International. 244: 1–6. doi:10.1016/j.forsciint.2014.07.024. PMID 25126738.

[8] "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. Retrieved 2008-03-24.

[Elks2014-9] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1228–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-10] Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1054–. ISBN 978-3-88763-075-1.

v t e Stomatological preparations (A01)
Caries prophylaxis	Dectaflur Olaflur Sodium fluoride Sodium monofluorophosphate Stannous fluoride
Infection and antiseptics	Amphotericin B Benzoxonium chloride Chlorhexidine Chlortetracycline Clotrimazole Cetylpyridinium chloride Domiphen bromide Doxycycline Eugenol Hexetidine Hydrogen peroxide Mepartricin Metronidazole Miconazole Minocycline Natamycin Neomycin Oxyquinoline Polynoxylin Sodium perborate Tetracycline Tibezonium iodide
Corticosteroids (Glucocorticoids)	Dexamethasone Hydrocortisone Triamcinolone
Other	Amlexanox Acetylsalicylic acid Becaplermin Benzydamine Epinephrine/Adrenalone

リンク元	「酢酸トリアムシノロン」「triamcinolone hexacetonide」「二酢酸トリアムシノロン」
関連記事	「diacetate」「triamcinolone」

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案内

triamcinolone diacetate