WordNet

occurring through or by way of the placenta; "transplacental passage of nutrients"

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1. Measles: Epidemiology and transmission
2. 幼児および18ヶ月未満の小児におけるＨＩＶ感染診断テスト diagnostic testing for hiv infection in infants and children younger than 18 months
3. 先天性トキソプラズマ症：臨床的特徴および診断 congenital toxoplasmosis clinical features and diagnosis
4. シャーガス病：自然史と診断 chagas disease natural history and diagnosis
5. バベシア症の疫学および病因 epidemiology and pathogenesis of babesiosis

English Journal

Maternal-fetal-infant dynamics of the C3-epimer of 25-hydroxyvitamin D.

Bailey D1, Perumal N2, Yazdanpanah M3, Al Mahmud A4, Baqui AH5, Adeli K6, Roth DE2.Author information 1Clinical Biochemistry, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Gamma-Dynacare Medical Laboratories, London, Ontario, Canada.2Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.3Clinical Biochemistry, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Canada.4International Center for Diarrheal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh.5International Center for Diarrheal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh; International Center for Maternal and Newborn Health, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.6Clinical Biochemistry, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.AbstractBACKGROUND: Poor vitamin D status (i.e. low serum 25-hydroxyvitamin D (25(OH)D)) has been associated with adverse clinical outcomes during pregnancy and childhood. However, the interpretation of serum 25(OH)D levels may be complicated by the presence of the C3-epimer of 25(OH)D. We aimed to quantify C3-epi-25(OH)D3 in pregnant women and fetuses, to explore the relationship of the C3-epimer between maternal and cord samples, and to establish whether infant C3-epimer abundance is explained by prenatal formation.
Clinical biochemistry.Clin Biochem.2014 Jan 22. pii: S0009-9120(14)00018-6. doi: 10.1016/j.clinbiochem.2014.01.015. [Epub ahead of print]
BACKGROUND: Poor vitamin D status (i.e. low serum 25-hydroxyvitamin D (25(OH)D)) has been associated with adverse clinical outcomes during pregnancy and childhood. However, the interpretation of serum 25(OH)D levels may be complicated by the presence of the C3-epimer of 25(OH)D. We aimed to quantify
PMID 24462965

Extremely hypotrophic newborn of mother with systemic lupus erythematosus and antiphospholipid syndrome.

Mockova A1, Dortova E, Dort J, Nahlovsky J, Korecko V, Ulcova-Gallova Z.Author information 11Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Czech Republic.AbstractThe case presented describes a high-risk pregnancy of a woman with systemic lupus erythematosus (SLE) with multiple lesions of central nervous system (CNS), vasculitis, secondary epilepsy and antiphospholipid syndrome (APS). At gestational age 28 weeks and 3 days the pregnancy was urgently terminated via caesarean section and an extremely hypotrophic immature newborn with a birth weight of 580 g was born. The high disease activity in the mother at the time of conception and the histologically proven chronic placental insufficiency due to APS are presumably the causes for the extensive hypotrophy of the neonate. The significant comorbidity of the newborn, including respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, osteopathy of prematurity, transient hypothyroidism and hypocortisolism, vesicoureteral reflux, and hypertonic-hyperexcitation syndrome complicated his three-month stay in NICU. A positive titre of transplacentally transferred anticardiolipin and anti-β2 glycoprotein antibody was detected in the child and persisted through the following 30 months. During the three-year follow-up, significantly delayed neuropsychological development with microcephaly (-4 SD) and short stature of the child was observed. Finally, the authors discuss possible causes of neuropsychological consequences in children of mothers with SLE and APS and emphasize the need for long-term monitoring and specialized care to improve development of these children.
Lupus.Lupus.2014;23(3):313-8. doi: 10.1177/0961203313517406. Epub 2013 Dec 19.
The case presented describes a high-risk pregnancy of a woman with systemic lupus erythematosus (SLE) with multiple lesions of central nervous system (CNS), vasculitis, secondary epilepsy and antiphospholipid syndrome (APS). At gestational age 28 weeks and 3 days the pregnancy was urgently terminate
PMID 24356613

Maternal bisphenol a exposure impacts the fetal heart transcriptome.

Chapalamadugu KC1, Vandevoort CA2, Settles ML3, Robison BD4, Murdoch GK1.Author information 1Department of Animal and Veterinary Science, University of Idaho, Moscow, Idaho, United States of America.2Department of Obstetrics and Gynecology, University of California Davis, Davis, California, United States of America ; California National Primate Research Center, University of California Davis, Davis, California, United States of America.3Department of Computer Science, University of Idaho, Moscow, Idaho, United States of America ; Program in Bioinformatics and Computational Biology, University of Idaho, Moscow, Idaho, United States of America.4Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America ; Program in Bioinformatics and Computational Biology, University of Idaho, Moscow, Idaho, United States of America.AbstractConditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis. Fetal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA exposure on cardiac development have not been assessed. With evidence that maternal BPA is transplacentally delivered to the developing fetus, it becomes imperative to examine the physiological consequences of gestational exposure during primate development. Herein, we evaluate the effects of daily, oral BPA exposure of pregnant rhesus monkeys (Macaca mulatta) on the fetal heart transcriptome. Pregnant monkeys were given daily oral doses (400 µg/kg body weight) of BPA during early (50-100±2 days post conception, dpc) or late (100±2 dpc - term), gestation. At the end of treatment, fetal heart tissues were collected and chamber specific transcriptome expression was assessed using genome-wide microarray. Quantitative real-time PCR was conducted on select genes and ventricular tissue glycogen content was quantified. Our results show that BPA exposure alters transcription of genes that are recognized for their role in cardiac pathophysiologies. Importantly, myosin heavy chain, cardiac isoform alpha (Myh6) was down-regulated in the left ventricle, and 'A Disintegrin and Metalloprotease 12', long isoform (Adam12-l) was up-regulated in both ventricles, and the right atrium of the heart in BPA exposed fetuses. BPA induced alteration of these genes supports the hypothesis that exposure to BPA during fetal development may impact cardiovascular fitness. Our results intensify concerns about the role of BPA in the genesis of human metabolic and cardiovascular diseases.
PloS one.PLoS One.2014 Feb 25;9(2):e89096. doi: 10.1371/journal.pone.0089096. eCollection 2014.
Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis. Fetal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA
PMID 24586524