This condition can also be referred to as subglottic or tracheal stenosis.
Specialty
Otorhinolaryngology
Laryngotracheal stenosis refers to abnormal narrowing of the central air passageways.[1] This can occur at the level of the larynx, trachea, carina or main bronchi.[2]
In a small number of patients narrowing may be present in more than one anatomical location.
Contents
1Presentation
2Causes
3Diagnosis
4Treatment
5Nomenclature
6See also
7References
8External links
Presentation
The most common symptom of laryngotracheal stenosis is gradually-worsening breathlessness (dyspnea) particularly when undertaking physical activities (exertional dyspnea). The patient may also experience added respiratory sounds which in the more severe cases can be identified as stridor but in many cases can be readily mistaken for wheeze. This creates a diagnostic pitfall in which many patients with laryngotracheal stenosis are incorrectly diagnosed as having asthma and are treated for presumed lower airway disease.[3][4][5][6][7][8] This increases the likelihood of the patient eventually requiring major open surgery in benign disease[9] and can lead to tracheal cancer presenting too late for curative surgery to be performed.
Causes
Laryngotracheal stenosis is an umbrella term for a wide and heterogeneous group of very rare conditions. The population incidence of adult post-intubation laryngotracheal stenosis which is the commonest benign sub-type of this condition is approximately 1 in 200,000 adults per year.[10] The main causes of adult laryngotracheal stenosis are:
Intubation/tracheostomy-related (most common cause)[16][17]
Granulomatosis with polyangiitis[18]
Idiopathic Progressive Subglottic Stenosis
Amyloidosis
Tracheopathia osteoplastica
Tracheomalacia
Expiratory Dynamic Airway Collapse (EDAC)
Tracheobronchomalacia
Relapsing polychondritis[19][20]
Tracheal ring damage due to COPD
Tracheal ring weakness
Benign tumors (e.g. Carcinoid)
Tracheal trauma / rupture[21]
Congenital subglottic/tracheal anomalies
Complete tracheal rings
Congenital subglottic/tracheal webs
Subglottic haemangioma
Subglottic / tracheal cysts[6]
At the level of carina or main bronchi
Granulomatosis with polyangiitis
Foreign body inhalation
Tuberculosis
Following Photodynamic Therapy
Head and neck (especially laryngeal or supraglottic) cancers
Primary tracheal cancers
Erosive thyroid cancer
Erosive esophageal cancer[22]
Lung cancer causing central airway obstruction[11]
Diagnosis
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Treatment
The optimal management of laryngotracheal stenosis is not well defined, depending mainly on the type of the stenosis.[23]
General treatment options include
Tracheal dilation using rigid bronchoscope
Laser surgery and endoluminal stenting[24]
Tracheal resection and laryngotracheal reconstruction[21][25]
Tracheal dilation is used to temporarily enlarge the airway. The effect of dilation typically lasts from a few days to 6 months. Several studies have shown that as a result of mechanical dilation (used alone) may occur a high mortality rate and a rate of recurrence of stenosis higher than 90%.[23]
Thus, many authors treat the stenosis by endoscopic excision with laser (commonly either the carbon dioxide or the neodymium: yttrium aluminum garnet laser) and then by using bronchoscopic dilatation and prolonged stenting with a T-tube (generally in silicone).[26][27][28]
There are differing opinions on treating with laser surgery.
In very experienced surgery centers, tracheal resection and reconstruction (anastomosis complete end-to-end with or without laryngotracheal temporary stent to prevent airway collapse) is currently the best alternative to completely cure the stenosis and allows to obtain good results. Therefore, it can be considered the gold standard treatment and is suitable for almost all patients.[29]
The narrowed part of the trachea will be cut off and the cut ends of the trachea sewn together with sutures. For stenosis of length greater than 5 cm a stent may be required to join the sections.
Late June or early July 2010, a new potential treatment was trialed at Great Ormond Street Hospital in London, where Ciaran Finn-Lynch (aged 11) received a transplanted trachea which had been injected with stem cells harvested from his own bone marrow. The use of Ciaran's stem cells was hoped to prevent his immune system from rejecting the transplant,[30] but there remain doubts about the operation's success, and several later attempts at similar surgery have been unsuccessful.
Nomenclature
Laryngotracheal stenosis (Laryngo-: Glottic Stenosis; Subglottic Stenosis; Tracheal: narrowings at different levels of the windpipe) is a more accurate description for this condition when compared, for example to subglottic stenosis which technically only refers to narrowing just below vocal folds or tracheal stenosis. In babies and young children however, the subglottis is the narrowest part of the airway and most stenoses do in fact occur at this level. Subglottic stenosis is often therefore used to describe central airway narrowing in children, and laryngotracheal stenosis is more often used in adults.
See also
Hermes Grillo pioneer in tracheal resection surgery
References
^Gelbard, A (2014). "Causes and Consequences of Laryngotracheal Stenosis". The Laryngoscope. 125 (5): 1137–1143. doi:10.1002/lary.24956. PMC 4562418. PMID 25290987.
^Armstrong WB, Netterville JL (August 1995). "Anatomy of the larynx, trachea, and bronchi". Otolaryngol. Clin. North Am. 28 (4): 685–99. PMID 7478631.
^Catenacci MH (July 2006). "A case of laryngotracheal stenosis masquerading as asthma". South. Med. J. 99 (7): 762–4. doi:10.1097/01.smj.0000217498.70967.77. PMID 16866062.
^Ricketti PA, Ricketti AJ, Cleri DJ, Seelagy M, Unkle DW, Vernaleo JR (2010). "A 41-year-old male with cough, wheeze, and dyspnea poorly responsive to asthma therapy". Allerg Asthma Proc. 31 (4): 355–8. doi:10.2500/aap.2010.31.3344. PMID 20819328.
^Scott PM, Glover GW (1995). "All that wheezes is not asthma". Br J Clin Pract. 49 (1): 43–4. PMID 7742187.
^ abKokturk N, Demircan S, Kurul C, Turktas H (October 2004). "Tracheal adenoid cystic carcinoma masquerading asthma: a case report". BMC Pulm Med. 4: 10. doi:10.1186/1471-2466-4-10. PMC 526771. PMID 15494074.
^Parrish RW, Banks J, Fennerty AG (December 1983). "Tracheal obstruction presenting as asthma". Postgrad Med J. 59 (698): 775–6. doi:10.1136/pgmj.59.698.775. PMC 2417814. PMID 6318209.
^Galvin IF, Shepherd DR, Gibbons JR (1990). "Tracheal stenosis caused by congenital vascular ring anomaly misinterpreted as asthma for 45 years". Thorac Cardiovasc Surg. 38 (1): 42–4. doi:10.1055/s-2007-1013990. PMID 2309228.
^Nouraei SA, Singh A, Patel A, Ferguson C, Howard DJ, Sandhu GS (August 2006). "Early endoscopic treatment of acute inflammatory airway lesions improves the outcome of postintubation airway stenosis". Laryngoscope. 116 (8): 1417–21. doi:10.1097/01.mlg.0000225377.33945.14. PMID 16885746.
^Nouraei SA, Ma E, Patel A, Howard DJ, Sandhu GS (October 2007). "Estimating the population incidence of adult post-intubation laryngotracheal stenosis". Clin Otolaryngol. 32 (5): 411–2. doi:10.1111/j.1749-4486.2007.01484.x. PMID 17883582.
^ abLu MS, Liu YH, Ko PJ, Wu YC, Hsieh MJ, Liu HP, Lin PJ (April 2003). "Preliminary experience with bronchotherapeutic procedures in central airway obstruction". Chang Gung Med J. 26 (4): 240–9. PMID 12846523.
^Tsutsui H, Kubota M, Yamada M, Suzuki A, Usuda J, Shibuya H, Miyajima K, Sugino K, Ito K, Furukawa K, Kato H (September 2008). "Airway stenting for the treatment of laryngotracheal stenosis secondary to thyroid cancer". Respirology. 13 (5): 632–8. doi:10.1111/j.1440-1843.2008.01309.x. PMID 18513246.
^Peña J, Cicero R, Marín J, Ramírez M, Cruz S, Navarro F (October 2001). "Laryngotracheal reconstruction in subglottic stenosis: an ancient problem still present". Otolaryngol Head Neck Surg. 125 (4): 397–400. doi:10.1067/mhn.2001.117372. PMID 11593179.
^Bent J (July 2006). "Pediatric laryngotracheal obstruction: current perspectives on stridor". Laryngoscope. 116 (7): 1059–70. doi:10.1097/01.mlg.0000222204.88653.c6. PMID 16826038.
^Perkins JA, Inglis AF, Richardson MA (March 1998). "Iatrogenic airway stenosis with recurrent respiratory papillomatosis". Arch. Otolaryngol. Head Neck Surg. 124 (3): 281–7. doi:10.1001/archotol.124.3.281. PMID 9525512.
^Wood DE, Mathisen DJ (September 1991). "Late complications of tracheotomy". Clin. Chest Med. 12 (3): 597–609. PMID 1934960.
^Filocamo, G; Torreggiani, S; Agostoni, C; Esposito, S (April 2017). "Lung involvement in childhood onset granulomatosis with polyangiitis". Pediatric Rheumatology Online Journal. 15 (1): 28. doi:10.1186/s12969-017-0150-8. PMID 28410589.
^Chang SJ, Lu CC, Chung YM, Lee SS, Chou CT, Huang DF (June 2005). "Laryngotracheal involvement as the initial manifestation of relapsing polychondritis". J Chin Med Assoc. 68 (6): 279–82. doi:10.1016/S1726-4901(09)70151-0. PMID 15984823.
^Kim CM, Kim BS, Cho KJ, Hong SJ (April 2003). "Laryngotracheal involvement of relapsing polychondritis in a Korean girl". Pediatr. Pulmonol. 35 (4): 314–7. doi:10.1002/ppul.10247. PMID 12629631.
^ abMostafa BE, El Fiky L, El Sharnoubi M (July 2006). "Non-intubation traumatic laryngotracheal stenosis: management policies and results". Eur Arch Otorhinolaryngol. 263 (7): 632–6. doi:10.1007/s00405-006-0036-8. PMID 16633824.
^Wassermann K, Mathen F, Edmund Eckel H (October 2000). "Malignant laryngotracheal obstruction: a way to treat serial stenoses of the upper airways". Ann. Thorac. Surg. 70 (4): 1197–201. doi:10.1016/s0003-4975(00)01614-3. PMID 11081870.
^ abBrichet A, Verkindre C, Dupont J, Carlier ML, Darras J, Wurtz A, Ramon P, Marquette CH (April 1999). "Multidisciplinary approach to management of postintubation tracheal stenoses". Eur. Respir. J. 13 (4): 888–93. doi:10.1034/j.1399-3003.1999.13d32.x. PMID 10362058.
^Ciccone AM, De Giacomo T, Venuta F, Ibrahim M, Diso D, Coloni GF, Rendina EA (October 2004). "Operative and non-operative treatment of benign subglottic laryngotracheal stenosis". Eur J Cardiothorac Surg. 26 (4): 818–22. doi:10.1016/j.ejcts.2004.06.020. PMID 15450579.
^Shapshay SM, Beamis JF, Hybels RL, Bohigian RK (1987). "Endoscopic treatment of subglottic and tracheal stenosis by radial laser incision and dilation". Ann. Otol. Rhinol. Laryngol. 96 (6): 661–4. doi:10.1177/000348948709600609. PMID 3688753.
^Shapshay SM, Beamis JF, Dumon JF (November 1989). "Total cervical tracheal stenosis: treatment by laser, dilation, and stenting". Ann. Otol. Rhinol. Laryngol. 98 (11): 890–5. doi:10.1177/000348948909801110. PMID 2817681.
^Mehta AC, Lee FY, Cordasco EM, Kirby T, Eliachar I, De Boer G (September 1993). "Concentric tracheal and subglottic stenosis. Management using the Nd-YAG laser for mucosal sparing followed by gentle dilatation". Chest. 104 (3): 673–7. doi:10.1378/chest.104.3.673. PMID 8365273.
^Gómez-Caro A, Morcillo A, Wins R, Molins L, Galan G, Tarrazona V (January 2011). "Surgical management of benign tracheal stenosis". Multimed Man Cardiothorac Surg. 2011 (1111): mmcts.2010.004945. doi:10.1510/mmcts.2010.004945. PMID 24413853.
^"New throat surgery 'a success'". BBC News. 2010-08-06.
Bibliography
Ongkasuwan, Julina (2006-02-09). "Tracheal Stenosis". Baylor College of Medicine. Archived from the original on 2007-02-20. Retrieved 2007-03-17.
External links
Classification
D
ICD-10: Q31.1, Q32.1, J38.6, J39.8, J95.5
ICD-9-CM: 519.19, 748.3
MeSH: D014135
v
t
e
Diseases of the respiratory system (J, 460–519)
Upper RT (including URTIs, common cold)
Head
sinuses
Sinusitis
nose
Rhinitis
Vasomotor rhinitis
Atrophic rhinitis
Hay fever
Nasal polyp
Rhinorrhea
nasal septum
Nasal septum deviation
Nasal septum perforation
Nasal septal hematoma
tonsil
Tonsillitis
Adenoid hypertrophy
Peritonsillar abscess
Neck
pharynx
Pharyngitis
Strep throat
Laryngopharyngeal reflux (LPR)
Retropharyngeal abscess
larynx
Croup
Laryngomalacia
Laryngeal cyst
Laryngitis
Laryngopharyngeal reflux (LPR)
Laryngospasm
vocal folds
Laryngopharyngeal reflux (LPR)
Vocal fold nodule
Vocal fold paresis
Vocal cord dysfunction
epiglottis
Epiglottitis
trachea
Tracheitis
Laryngotracheal stenosis
Lower RT/lung disease (including LRTIs)
Bronchial/ obstructive
acute
Acute bronchitis
chronic
COPD
Chronic bronchitis
Acute exacerbations of chronic bronchitis
Acute exacerbation of COPD
Emphysema)
Asthma (Status asthmaticus
Aspirin-induced
Exercise-induced
Bronchiectasis
unspecified
Bronchitis
Bronchiolitis
Bronchiolitis obliterans
Diffuse panbronchiolitis
Interstitial/ restrictive (fibrosis)
External agents/ occupational lung disease
Pneumoconiosis
Aluminosis
Asbestosis
Baritosis
Bauxite fibrosis
Berylliosis
Caplan's syndrome
Chalicosis
Coalworker's pneumoconiosis
Siderosis
Silicosis
Talcosis
Byssinosis
Hypersensitivity pneumonitis
Bagassosis
Bird fancier's lung
Farmer's lung
Lycoperdonosis
Other
ARDS
Combined pulmonary fibrosis and emphysema
Pulmonary edema
Löffler's syndrome/Eosinophilic pneumonia
Respiratory hypersensitivity
Allergic bronchopulmonary aspergillosis
Hamman-Rich syndrome
Idiopathic pulmonary fibrosis
Sarcoidosis
Obstructive or restrictive
Pneumonia/ pneumonitis
By pathogen
Viral
Bacterial
Pneumococcal
Klebsiella)
Atypical bacterial
Mycoplasma
Legionnaires' disease
Chlamydiae
Fungal
Pneumocystis
Parasitic
noninfectious
Chemical/Mendelson's syndrome
Aspiration/Lipid
By vector/route
Community-acquired
Healthcare-associated
Hospital-acquired
By distribution
Broncho-
Lobar
IIP
UIP
DIP
BOOP-COP
NSIP
RB
Other
Atelectasis
circulatory
Pulmonary hypertension
Pulmonary embolism
Lung abscess
Pleural cavity/ mediastinum
Pleural disease
Pleuritis/pleurisy
Pneumothorax/Hemopneumothorax
Pleural effusion
Hemothorax
Hydrothorax
Chylothorax
Empyema/pyothorax
Malignant
Fibrothorax
Mediastinal disease
Mediastinitis
Mediastinal emphysema
Other/general
Respiratory failure
Influenza
SARS
Idiopathic pulmonary haemosiderosis
Pulmonary alveolar proteinosis
v
t
e
Congenital malformations and deformations of respiratory system (Q30–Q34, 748)
Upper RT
Nose
Choanal atresia
Arrhinia
Larynx
Laryngeal cyst
Laryngocele
Laryngomalacia
Lower RT
Trachea and bronchus
Tracheomalacia
Tracheal stenosis
Bronchomalacia
Tracheobronchomegaly
Lung
Bronchiectasis
Pulmonary hypoplasia
Pulmonary sequestration
Congenital cystic adenomatoid malformation
UpToDate Contents
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CONCLUSION: Delivery of a carbon dioxide laser is an effective method and can be used in selected cases of tracheal stenosis.OBJECTIVES: To present retrospective experience in tracheal stenosis of 16 patients treated by bronchoscopic delivery of carbon dioxide laser, considering the characteristics
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Wang H1, Wright CD2, Wain JC2, Ott HC2, Mathisen DJ3.
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BACKGROUND: Idiopathic subglottic stenosis is a rare inflammatory condition affecting the subglottic larynx. We have treated 263 patients (only 2 were male) with this condition. The purpose of this study is to determine factors affecting outcome and predisposing to complications.METHODS: Information
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