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street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

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酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/20 23:55:14」(JST)

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Tiludronic acid (INN; also known as tiludronate) is a bisphosphonate used for treatment of Paget's disease of bone (osteitis deformans) in human medicine. It has the tradename Skelid. In veterinary medicine, tiludronic acid is used to treat navicular disease and bone spavin in horses. Its tradenames are Tildren and Equidronate.

Administration[edit]

In human medicine, tiludronic acid is administered orally. The recommended dose is a single 400 mg daily oral dose, taken with 6 to 8 ounces of plain water only, should be administered for a period of 3 months. Beverages other than plain water (including mineral water), food, and some medications are likely to reduce absorption.

In horses, tiludronic acid is administered by IV infusion as absorption by oral route is very poor. The recommended dose is 1 mg/kg mixed with saline. The infusion should last at least 30 mn to avoid side effects.

External links[edit]

Prescribing information for Skelid
RxList page
tildren.com

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 閉経後女性における骨粗鬆症に対するビスホスホネート投与 the use of bisphosphonates in postmenopausal women with osteoporosis
2. 骨パジェット病の治療 treatment of paget disease of bone
3. ビスホスホネートの薬理学 pharmacology of bisphosphonates
4. 乳癌、卵巣癌、およびその他の固形腫瘍からの骨転移患者に対する骨吸収抑制剤 osteoclast inhibitors for patients with bone metastases from breast prostate and other solid tumors
5. 多発性骨髄腫患者への骨吸収抑制薬の使用 the use of osteoclast inhibitors in patients with multiple myeloma

English Journal

Effects of Local Administration of Tiludronic Acid on Experimental Periodontitis in Diabetic Rats.

Nunes NLT1, Messora MR2, Oliveira LF2, Lisboa M3, Barcellos Garcia MC2, Rêgo ROCC4, Novaes AB Junior2, Scombatti de Souza SL2, Ervolino E5, Furlaneto FAC2.
Journal of periodontology.J Periodontol.2017 Sep 15:1-19. doi: 10.1902/jop.2017.170228. [Epub ahead of print]
PMID 28914593

Quantitative assessment of two methods of tiludronate administration for the treatment of lameness caused by navicular syndrome in horses.

Whitfield CT, Schoonover MJ, Holbrook TC, Payton ME, Sippel KM.
American journal of veterinary research.Am J Vet Res.2016 Feb;77(2):167-73. doi: 10.2460/ajvr.77.2.167.
OBJECTIVE: To determine effects of 2 tiludronate administration protocols on measures of lameness in horses with navicular syndrome (NS).ANIMALS: 12 horses with bilateral forelimb NS.PROCEDURES: Horses were randomly assigned to receive tiludronate (1 mg/kg), diluted in 5 L of isotonic electrolyte so
PMID 27027711

Licence variations regarding tiludronate disodium.

Gourlay J1.
The Veterinary record.Vet Rec.2015 Oct 24;177(16):423-4. doi: 10.1136/vr.h5621.
PMID 26494897

Japanese Journal

Signal changes in standing magnetic resonance imaging of osseous injury at the origin of the suspensory ligament in four Thoroughbred racehorses under tiludronic acid treatment

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｑｕｉｎｅ　Ｓｃｉｅｎｃｅ 28(3), 87-97, 2017
NAID 130006083342

「チルドロン酸」

Tiludronic acid
Systematic (IUPAC) name
	{[(4-Chlorophenyl)thio]methylene}bis(phosphonic acid)
Clinical data
Trade names	Skelid
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	89987-06-4
ATC code	M05BA05
PubChem	CID 60937
DrugBank	DB01133
UNII	6PNS59HP4Y
KEGG	D08599
ChEMBL	CHEMBL1350
Chemical data
Formula	C7H9ClO6P2S
Mol. mass	318.609 g/mol
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