thrombosis

血栓症 　 　

WordNet

1. the formation or presence of a thrombus (a clot of coagulated blood attached at the site of its formation) in a blood vessel

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1. 血栓症

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/08 23:56:05」(JST)

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Thrombosis
Classification and external resources
Cyanosis of the lower right extremity, resulting from acute arterial thrombosis of the right leg
ICD-10	I80-I82
ICD-9	437.6, 453, 671.5, 671.9
MeSH	D013927

Thrombosis (Greek: θρόμβωσις) is the formation of a blood clot (thrombus; Greek: θρόμβος) inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot that breaks free and begins to travel around the body is known as an embolus.

When a thrombus occupies more than 75%^{[citation needed]} of cross-sectional area of the lumen of an artery, blood flow to the tissue supplied is reduced enough to cause symptoms because of decreased oxygen (hypoxia) and accumulation of metabolic products like lactic acid. More than 90%^{[citation needed]} obstruction can result in anoxia, the complete deprivation of oxygen, and infarction, a mode of cell death.

Thromboembolism is the combination of thrombosis and its main complication, embolism.

Causes

In classical terms, thrombosis is caused by abnormalities in one or more of the following (Virchow's triad):

• The composition of the blood (hypercoagulability or thrombophilia)
• Quality of the vessel wall (endothelial cell injury)
• Nature of the blood flow (stasis, turbulence)

Hypercoagulability

Main article: Thrombophilia

Hypercoagulability is caused by, for example, genetic deficiencies or autoimmune disorders. Recent studies indicate that neutrophils play a pivotal role in deep venous thrombosis, mediating numerous pro-thrombotic actions

Endothelial cell injury

Causes of injury to the vessel's wall include trauma, surgery, infection or turbulent flow at bifurcations. The main mechanism is exposure of tissue factor to the blood coagulation system.

Disturbed blood flow

Further information: Blood flow

Causes of disturbed blood flow include stagnation of blood flow past the point of injury, or venous stasis which may occur in heart failure or after long periods of sedentary behavior, such as sitting on a long airplane flight. Also, atrial fibrillation, causes stagnant blood in the left atrium (LA) or left atrial appendage (LAA), and can lead to a thromboembolism. Cancers or malignancies such as leukemia may cause increased risk of thrombosis by external compression on a blood vessel for example, or (more rarely) extension into the vasculature (for example, renal cell cancers extending into the renal veins). Also, treatments for cancer (radiation, chemotherapy) often cause additional hypercoagulability.

Classification

There are two distinct forms of thrombosis, venous thrombosis and arterial thrombosis, each of which can be presented by several subtypes.

Venous thrombosis

Main article: Venous thrombosis

Venous thrombosis is the formation of a thrombus (blood clot) within a vein. There are several diseases which can be classified under this category:

Deep vein thrombosis

Main article: Deep vein thrombosis

Deep vein thrombosis (DVT) is the formation of a blood clot within a deep vein. It most commonly affects leg veins, such as the femoral vein. Three factors are important in the formation of a blood clot within a deep vein—these are the rate of blood flow, the thickness of the blood and qualities of the vessel wall. Classical signs of DVT include swelling, pain and redness of the affected area.

Portal vein thrombosis

Main article: Portal vein thrombosis

Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead to portal hypertension and reduction of the blood supply to the liver. It usually has a pathological cause such as pancreatitis, cirrhosis, diverticulitis or cholangiocarcinoma.

Renal vein thrombosis

Main article: Renal vein thrombosis

Renal vein thrombosis is the obstruction of the renal vein by a thrombus. This tends to lead to reduced drainage from the kidney. Anticoagulation therapy is the treatment of choice.

Jugular vein thrombosis

Main article: Jugular vein thrombosis

Jugular vein thrombosis is a condition that may occur due to infection, intravenous drug use or malignancy. Jugular vein thrombosis can have a varying list of complications, including: systemic sepsis, pulmonary embolism, and papilledema. Though characterized by a sharp pain at the site of the vein, it can prove difficult to diagnose, because it can occur at random.

Budd-Chiari syndrome

Main article: Budd-Chiari syndrome

Budd-Chiari syndrome is the blockage of the hepatic vein or the inferior vena cava. This form of thrombosis presents with abdominal pain, ascites and hepatomegaly. Treatment varies between therapy and surgical intervention by the use of shunts.

Paget-Schroetter disease

Main article: Paget-Schroetter disease

Paget-Schroetter disease is the obstruction of an upper extremity vein (such as the axillary vein or subclavian vein) by a thrombus. The condition usually comes to light after vigorous exercise and usually presents in younger, otherwise healthy people. Men are affected more than women.

Cerebral venous sinus thrombosis

Main article: Cerebral venous sinus thrombosis

Cerebral venous sinus thrombosis (CVST) is a rare form of stroke which results from the blockage of the dural venous sinuses by a thrombus. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body and seizures. The diagnosis is usually made with a CT or MRI scan. The majority of persons affected make a full recovery. The mortality rate is 4.3%.

Arterial thrombosis

Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial thrombosis follows rupture of atheroma, and is therefore referred to as atherothrombosis.

Another common cause of arterial occlusion is atrial fibrillation, which causes a blood stasis within the atria with easy thrombus formation. In addition, it is well known that the direct current cardioversion of atrial fibrillation carries a great risk of thromboembolism, especially if persisting more than 48 hours. Thromboembolism strikes approximately 5% of cases not receiving anticoagulant therapy. When cardiac rhythm is restored clots are pushed out from atria to ventricles and from these to the aorta and its branches.

Arterial thrombosis can embolize and is a major cause of arterial embolism, potentially causing infarction of almost any organ in the body.

Stroke

Main article: Stroke

A stroke is the rapid decline of brain function due to a disturbance in the supply of blood to the brain. This can be due to ischemia, thrombus, embolus (a lodged particle) or hemorrhage (a bleed). In thrombotic stroke, a thrombus (blood clot) usually forms around atherosclerotic plaques. Since blockage of the artery is gradual, onset of symptomatic thrombotic strokes is slower. Thrombotic stroke can be divided into two categories—large vessel disease and small vessel disease. The former affects vessels such as the internal carotids, vertebral and the circle of Willis. The latter can affect smaller vessels such as the branches of the circle of Willis.

Myocardial infarction

Main article: Myocardial infarction

Myocardial infarction (MI) is caused by an infarct (death of tissue due to ischemia), often due to the obstruction of a coronary artery by a thrombus. MI can quickly become fatal if emergency medical treatment is not received promptly. If diagnosed within 12 hours of the initial episode (attack) then thrombolytic therapy is initiated.

Other sites

Hepatic artery thrombosis usually occurs as a devastating complication after liver transplantation.

An arterial embolus can also form in the limbs.

Embolization

If a bacterial infection is present at the site of thrombosis, the thrombus may break down, spreading particles of infected material throughout the circulatory system (pyemia, septic embolus) and setting up metastatic abscesses wherever they come to rest. Without an infection, the thrombus may become detached and enter circulation as an embolus, finally lodging in and completely obstructing a blood vessel, which unless treated very quickly will lead to tissue necrosis (an infarction) in the area past the occlusion. If the occlusion is in the coronary artery, myocardial ischaemia is likely to occur, whereby cardiac myocytes cannot function properly due to lack of oxygen. This lack of oxygen is then likely to result in a myocardial infarction.

Most thrombi, however, become organized into fibrous tissue, and the thrombosed vessel is gradually recanalized.

Prevention

Prophylaxis of venous thromboembolism with heparin in medical patients does not appear to decrease mortality and while it may decrease the risk of pulmonary embolism and deep vein thrombosis it increases the risk of bleeding and thus results in little or no overall clinical benefit. Mechanical measures also appeared of little benefit in this group and in those with a stroke resulted in harm. Evidence supports the use of heparin following surgery which has a high risk of thrombosis to reduce the risk of DVTs; however the effect on PEs or overall mortality is not known.

Generally, a risk-benefit analysis is required, as all anticoagulants lead to a small increase in the risk of major bleeding. In atrial fibrillation, for instance, the risk of stroke (calculated on the basis of additional risk factors, such as advanced age and high blood pressure) needs to outweigh the small but known risk of major bleeding associated with the use of warfarin.

In people admitted to hospital, thrombosis is a major cause for complications and occasionally death. In the UK, for instance, the Parliamentary Health Select Committee heard in 2005 that the annual rate of death due to hospital-acquired thrombosis was 25,000. Hence thromboprophylaxis (prevention of thrombosis) is increasingly emphasized. In patients admitted for surgery, graded compression stockings are widely used, and in severe illness, prolonged immobility and in all orthopedic surgery, professional guidelines recommend low molecular weight heparin (LMWH) administration, mechanical calf compression or (if all else is contraindicated and the patient has recently suffered deep vein thrombosis) the insertion of a vena cava filter. In patients with medical rather than surgical illness, LMWH too is known to prevent thrombosis, and in the United Kingdom the Chief Medical Officer has issued guidance to the effect that preventative measures should be used in medical patients, in anticipation of formal guidelines.

Treatment

Vitamin K antagonist-oral anticoagulants reduce thromboembolic occurrence. As side effect, the risk of bleeding is increased, so the international normalized ratio of blood is monitored. Self-monitoring and self-management are safe options for competent patients, though their practice varies. In Germany, about 20% of patients were self-managed while only 1% of U.S. patients did home self-testing.

See also

• National Blood Clot Alliance
• Blood clotting tests

References

UpToDate Contents

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• 1. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
• 2. 静脈血栓症が確認された患者の後天的危険因子および遺伝的危険因子の評価 evaluating patients with established venous thromboembolism for acquired and inherited risk factors
• 3. 静脈血栓塞栓症の患者における理論的根拠と無期限の抗凝固の適応 rationale and indications for indefinite anticoagulation in patients with venous thromboembolism
• 4. Acute mesenteric arterial occlusion
• 5. 原発性（特発性）上肢深部静脈血栓症 primary spontaneous upper extremity deep vein thrombosis

English Journal

• TULA-family proteins: A new class of cellular regulators.

• Tsygankov AY.SourceDepartment of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology and Sol Sherry Thrombosis Center, Temple University School of Medicine, Philadelphia, Pennsylvania. alexander.tsygankov@temple.edu.
• Journal of cellular physiology.J Cell Physiol.2013 Jan;228(1):43-9. doi: 10.1002/jcp.24128.
• Proteins of the UBASH3/STS/TULA family recently emerged as potent regulators of cellular functions. They are characterized by a unique architecture, featuring at least three functional domains. One of them is a histidine phosphatase domain, which mediates the protein tyrosine phosphatase activity of
• PMID 22689384

• Yttrium 90 microspheres for the treatment of hepatocellular carcinoma.

• Memon K, Lewandowski RJ, Riaz A, Salem R.SourceDepartment of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA.
• Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer.Recent Results Cancer Res.2013;190:207-24.
• Yttrium-90 microspheres are radioactive particles which are increasingly being employed for treating patients with unresectable hepatocellular carcinoma (HCC). The procedure is called radioembolization. It involves the injection of micron-sized embolic particles loaded with a radioisotope by use of
• PMID 22941023

Japanese Journal

• Frequent Use of Fresh Frozen Plasma Is a Risk Factor for Venous Thrombosis in Extremely Low Birth Weight Infants: A Matched Case-control Study

• Maruyama Hidehiko,Kitajima Hiroyuki,Yonemoto Naohiro,Fujimura Masanori
• Acta Medica Okayama 66(1), 61-66, 2012-02
• … Venous thrombosis (VT) is one of the complications associated with PICC use. …
• NAID 120003850609

• 1)不育症における遺伝学的探索(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)

• 杉浦 真弓
• 日本産科婦人科學會雜誌 63(12), 2143-2152, 2011-12-01
• … APS should be distinguished from occasional antiphospholipid antibodies because patients with APS needed the prevention of thrombosis in the future. …
• NAID 110008799034

Related Links

• NPO法人日本血栓症協会

Japanese Thrombosis Association | とらえにくい"静脈血栓塞栓症"という病気の医療者と市民代表として犠牲者と後遺症を減らす ... エコノミークラス症候群についてはご存じでしょうか。血栓症（＝静脈血栓塞栓症）はこの病気と同じ原因で ...

• thrombosisの意味 - goo辞書 英和和英

thrombosisとは。意味や和訳。[名]（複 -ses 〔-siːz〕）[U][C]《病理(学)》血栓症，血栓形成.throm・bot・ic[形] - 40万項目以上収録、例文・コロケーションが豊富な無料英和和英辞典。

Related Pictures

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★リンクテーブル★

リンク元	「thromb」「血栓症」
拡張検索	「intracranial thrombosis」

「thromb」

　　[★]

• comb form.

• 血栓、血栓症

• ex.

• thrombosis 血栓症
• thrombasthenia 血小板無力症

「血栓症」

　　[★]

英

thrombosis(=血栓形成)

関

coagulation、静脈血栓症、動脈血栓症

「intracranial thrombosis」

　　[★]

脳血栓症、頭蓋内血栓症

関

cerebral thrombosis、thrombotic stroke