チオエステル加水分解酵素、チオエステルヒドロラーゼ

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1. チロシン代謝障害 disorders of tyrosine metabolism
2. 全身疾患と関連した遺伝性ニューロパチー hereditary neuropathies associated with generalized disorders
3. 新生児脳症の臨床的特徴、診断、および治療 clinical features diagnosis and treatment of neonatal encephalopathy
4. ブレオマイシン誘発性肺障害 bleomycin induced lung injury
5. グルコース-6-ホスファターゼ欠損症（糖原病I型、フォンギールケ病） glucose 6 phosphatase deficiency glycogen storage disease i von gierke disease

English Journal

Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.

Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P.SourceThe Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania, USA.
Journal of cellular physiology.J Cell Physiol.2012 May;227(5):2022-9. doi: 10.1002/jcp.22931.
Ubiquitin C-terminal hydrolases (UCHs) comprise a family of deubiquitinating enzymes that play a role in the removal of multi-ubiquitin chains from proteins that are posttranslationally modified by ubiquitination to be targeted for proteolysis by the 26S proteasome. The UCH-enzymes also generate fre
PMID 21751213

Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.

Mtango NR, Sutovsky M, Susor A, Zhong Z, Latham KE, Sutovsky P.SourceThe Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania, USA.
Journal of cellular physiology.J Cell Physiol.2012 Apr;227(4):1592-603. doi: 10.1002/jcp.22876.
Post-translational protein modification by ubiquitination, a signal for lysosomal or proteasomal proteolysis, can be regulated and reversed by deubiquitinating enzymes (DUBs). This study examined the roles of UCHL1 and UCHL3, two members of ubiquitin C-terminal hydrolase (UCH) family of DUBs, in mur
PMID 21678411

Related Links

GO:0016790 thiolester hydrolase activity - EMBL European ...

ID GO:0016790 Name thiolester hydrolase activity Ontology Molecular Function Definition Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a ...

GSEA | MSigDB | Gene Set: THIOLESTER_HYDROLASE ...

Standard name THIOLESTER_HYDROLASE_ACTIVITY Systematic name M5762 Brief description Genes annotated by the GO term GO:0016790. Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the ...