WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/01 01:20:16」(JST)

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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is used as a strong but short acting sedative. Thamylal is still in current use, primarily for induction in surgical anaesthesia ^[1] or as an anticonvulsant to counteract side effects from other anaesthetics. ^[2] It is the Thiobarbiturate anologue of secobarbital.

References

^ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
^ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.

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1. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン
症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
2. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
3. 低ナトリウム血症患者の評価 evaluation of the patient with hyponatremia
4. 成人における体液量減少の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of volume depletion in adults
5. 低ナトリウム血症患者におけるナトリウム欠乏の評価 estimation of the sodium deficit in patients with hyponatremia

English Journal

[Torsade de pointes associated with severe bradycardia after induction of general anesthesia].

Hamaguchi E, Kawano H, Kawahito S, Kitahata H, Oshita S.SourceDepartment of Anesthesiology, Tokushima University Hospital, Tokushima 770-8503.
Masui. The Japanese journal of anesthesiology.Masui.2011 Sep;60(9):1097-100.
An 80-year-old woman with chronic atrial flutter/fibrillation, and chronic renal failure underwent ileocecal resection. The preoperative electrocadiogram showed normal QT interval. Temporary pacemaker catheter was inserted for sinus arrest (5-6 sec) the day before operation. Anesthesia was induced w
PMID 21950046

[Noncardiac ST elevation during the ileus operation].

Murakami K, Fujita M, Iwamasa H, Kato K, Haratake Y.SourceDepartment of Anesthesiology, Saiseikai Kumamoto Hospital, Kumamoto 861-4193.
Masui. The Japanese journal of anesthesiology.Masui.2011 Jun;60(6):713-7.
A 59-year-old man had undergone the esophagectomy for esophageal carcinoma. Subsequently, he was scheduled to undergo the operation for ileus. He had midazolam 1 mg intramuscular injection before the surgery. General anesthesia was induced with thiamylal 62.5 mg and vecuronium 6 mg and maintained wi
PMID 21710770

Japanese Journal

チアミラールによる薬剤性白血球減少症が疑われた遅発性ジストニアの一症例

田根なつ紀,板垣大雅,奥田菜緒,小畠久和,中瀧恵実子,小野寺睦雄,今中秀光,西村匡司
日本集中治療医学会雑誌 21(2), 181-182, 2014
NAID 130004846857

修正型電気けいれん療法(mECT)施行時のthiamylal sodium投与量についての検討

岩本崇志,柴崎千代,藤田康孝 [他]
精神医学 52(9), 873-881, 2010-09
NAID 40017257032

早期新生児期から多方向性眼振，ジストニー，無呼吸発作を頻発した小児交代性片麻痺の１例

塩田直樹,下野昌幸,冨岡志保,高野健一,加藤絢子,川上章弘,石塚丈広
脳と発達 39(4), 285-288, 2007
… 救急外来受診時には, diazepamまたはthiamylal sodiumを静注し効果を得た. …
NAID 130004183870

「チアミラール」

Thiamylal
Systematic (IUPAC) name
	5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	Schedule III (CA) Schedule III (US)
Identifiers
CAS number	77-27-0
ATCvet code	QN01AF90
PubChem	CID 3032285
DrugBank	DB01154
ChemSpider	2297298
UNII	01T23W89FR
KEGG	D06106
ChEBI	CHEBI:9536
ChEMBL	CHEMBL440
Synonyms	Thiamylal, Thioseconal, Surital
Chemical data
Formula	C12H18N2O2S
Mol. mass	254.35 g/mol
	SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C;
	InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) ; Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N ;
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