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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/19 20:38:14」(JST)

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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is used as a strong but short acting sedative. Thamylal is still in current use, primarily for induction in surgical anaesthesia ^[1] or as an anticonvulsant to counteract side effects from other anaesthetics. ^[2] It is the Thiobarbiturate anologue of secobarbital.

References

^ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
^ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.

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1. 周術期アナフィラキシー：臨床症状、病因、および診断 perioperative anaphylaxis clinical manifestations etiology and diagnosis

English Journal

Barbiturate Induction for the Prevention of Emergence Agitation after Pediatric Sevoflurane Anesthesia.

Use T1, Nakahara H1, Kimoto A1, Beppu Y1, Yoshimura M1, Kojima T2, Fukano T1.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG.J Pediatr Pharmacol Ther.2015 Sep-Oct;20(5):385-92. doi: 10.5863/1551-6776-20.5.385.
OBJECTIVES: Emergence agitation (EA) is a common and troublesome problem in pediatric patients recovering from general anesthesia. The incidence of EA is reportedly higher after general anesthesia maintained with sevoflurane, a popular inhalational anesthetic agent for pediatric patients. We conduct
PMID 26472953

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

Thomas CM1, Timson DJ1.
Parasitology.Parasitology.2015 Sep;142(11):1375-86. doi: 10.1017/S0031182015000736. Epub 2015 Jul 8.
FhCaBP2 is a Fasciola hepatica protein which belongs to a family of helminth calcium-binding proteins which combine an N-terminal domain containing two EF-hand motifs and a C-terminal dynein light chain-like (DLC-like) domain. Its predicted structure showed two globular domains joined by a flexible
PMID 26152524

[Rapid Sequence Intubation with the McGRATH MAC Videolaryngoscope in the Sitting Position for a Patient with Restricted Mouth Opening].

Hasegawa Y, Komasawa N, Matsunami S, Kido H, Kusaka Y, Minami T.
Masui. The Japanese journal of anesthesiology.Masui.2015 Jun;64(6):632-4.
Here we report successful rapid-sequence inubation with the McGRATH MAC videolaryngscope (McGRATH) in the face to face sitting position for a patient with severe ileus and restricted mouse opening. A 46-year-old woman with advanced bladder cancer had developed ileus. Ileus tube and octreotide did no
PMID 26437554

Japanese Journal

チアミラールによる薬剤性白血球減少症が疑われた遅発性ジストニアの一症例

日本集中治療医学会雑誌 21(2), 181-182, 2014
NAID 130004846857

発症早期から血漿交換療法をふくむ免疫療法をおこなった，難治頻回の部分発作重積を呈した急性脳炎の1例

臨床神経学 54(9), 715-720, 2014
NAID 130004696171

貧血補正によって発症したposterior reversible encephalopathy syndromeの1例

臨床神経学 52(3), 147-151, 2012
NAID 130004505249

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★リンクテーブル★

リンク元	「チアミラール」
拡張検索	「thiamylal sodium」

「チアミラール」

Thiamylal
Systematic (IUPAC) name
	5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	Schedule III (CA) Schedule III (US)
Identifiers
CAS number	77-27-0
ATCvet code	QN01AF90
PubChem	CID 3032285
DrugBank	DB01154
ChemSpider	2297298
UNII	01T23W89FR
KEGG	D06106
ChEBI	CHEBI:9536
ChEMBL	CHEMBL440
Synonyms	Thiamylal, Thioseconal, Surital
Chemical data
Formula	C12H18N2O2S
Mol. mass	254.35 g/mol
	SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C;
	InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) ; Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N ;
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