WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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1. フェニルケトン尿症の概要 overview of phenylketonuria
2. ヘロイン吸入による白質脳症（chasing the dragon） leukoencephalopathy due to heroin inhalation chasing the dragon
3. 冠動脈内皮細胞機能不全：基本概念 coronary artery endothelial dysfunction basic concepts
4. 安定狭心症のマネージメントにおける硝酸塩 nitrates in the management of stable angina pectoris
5. ジストニアの分類および評価 classification and evaluation of dystonia

Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression.

Oelze M1, Knorr M, Kröller-Schön S, Kossmann S, Gottschlich A, Rümmler R, Schuff A, Daub S, Doppler C, Kleinert H, Gori T, Daiber A, Münzel T.
European heart journal.Eur Heart J.2013 Nov;34(41):3206-16. doi: 10.1093/eurheartj/ehs100. Epub 2012 May 3.
AIMS: Isosorbide-5-mononitrate (ISMN) is one of the most frequently used compounds in the treatment of coronary artery disease predominantly in the USA. However, ISMN was reported to induce endothelial dysfunction, which was corrected by vitamin C pointing to a crucial role of reactive oxygen specie
PMID 22555214

Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1.

Schuhmacher S1, Wenzel P, Schulz E, Oelze M, Mang C, Kamuf J, Gori T, Jansen T, Knorr M, Karbach S, Hortmann M, Mäthner F, Bhatnagar A, Förstermann U, Li H, Münzel T, Daiber A.
Hypertension.Hypertension.2010 Apr;55(4):897-904. doi: 10.1161/HYPERTENSIONAHA.109.149542. Epub 2010 Feb 15.
The organic nitrate pentaerythritol tetranitrate is devoid of nitrate tolerance, which has been attributed to the induction of the antioxidant enzyme heme oxygenase (HO)-1. With the present study, we tested whether chronic treatment with pentaerythritol tetranitrate can improve angiotensin II-induce
PMID 20157049

Discovery of a new tetrahydrobiopterin-synthesizing enzyme in the lemon mutant of the silkworm Bombyx mori.

Iino T1, Sawada H, Tsusué M, Takikawa S.
Biochimica et biophysica acta.Biochim Biophys Acta.1996 Oct 17;1297(2):191-9.
A new tetrahydrobiopterin-synthesizing enzyme, which is different from sepiapterin reductase (EC 1.1.1.153), was discovered in the integument of the lemon mutant of the silkworm Bombyx mori. This enzyme converted 6-pyruvoyltetrahydropterin to tetrahydrobiopterin, an essential cofactor in the hydroxy
PMID 8917621