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English Journal

Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats.

Pereira SP, Pereira GC, Pereira CV, Carvalho FS, Cordeiro MH, Mota PC, Ramalho-Santos J, Moreno AJ, Oliveira PJ.SourceCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal.
Environmental pollution (Barking, Essex : 1987).Environ Pollut.2013 Sep;180:281-90. doi: 10.1016/j.envpol.2013.05.049. Epub 2013 Jun 21.
The environmental dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is classified as a Group 1 human carcinogen and teratogenic agent. We hypothesize that TCDD-induced oxidative stress may also interfere with mitochondrial ATP-sensitive potassium channels (mitoKATP), which are known to regulate and
PMID 23796802

Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats.

Oguz F, Ciftci O, Aydın M, Timurkaan N, Beytur A, Altıntas R, Parlakpinar H.SourceDepartment of Urology, Faculty of Medicine, University of Inonu, Malatya, Turkey.
Andrologia.Andrologia.2013 Aug;45(4):225-31. doi: 10.1111/j.1439-0272.2012.01334.x. Epub 2012 Jul 4.
In this study, it was aimed to determinate protective effects of aminoguanidine (AG) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. Thirty-two rats were equally divided into four groups; the first group was kept as control and given
PMID 22762285

Molecular characterization of the aryl hydrocarbon receptor (AhR) pathway in goldfish (Carassius auratus) exposure to TCDD: The mRNA and protein levels.

Lu M, Chang Z, Bae MJ, Oh SM, Chung KH, Park JS.SourceDepartment of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 609-735, South Korea.
Fish & shellfish immunology.Fish Shellfish Immunol.2013 Aug;35(2):469-75. doi: 10.1016/j.fsi.2013.05.002. Epub 2013 May 28.
In bony fish or other aquatic vertebrates, the aryl hydrocarbon receptor (AhR) signaling pathway is initiated by exposure to polycyclic (or/and halogenated) aromatic hydrocarbons (PAHs, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), which subsequently induces the up-regulated expression of a s
PMID 23727285

山田英之,武田知起,古賀貴之 [他],石井祐次
YAKUGAKU ZASSHI 134(4), 529-535, 2014
… When pregnant rats are exposed to a prototype of dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; …
NAID 130003391201

3,3′,4,4′-Tetrachlorobiphenyl-Mediated Decrease of Serum Thyroxine Level in C57BL/6 and DBA/2 Mice Occurs Mainly through Enhanced Accumulation of Thyroxine in the Liver

Kato Yoshihisa,Haraguchi Koichi,Onishi Mao [他],Ikushiro Shinichi,Endo Tetsuya,Ohta Chiho,Koga Nobuyuki,Yamada Shizuo,Degawa Masakuni
Biological and Pharmaceutical Bulletin 37(3), 504-509, 2014
… A single intraperitoneal injection (50 mg/kg) of 3,3′,4,4′-tetrachlorobiphenyl (CB77), a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-type polychlorinated biphenyl, led to significant decreases in the levels of serum total thyroxine (T4) and free T4 without increase in the level of serum thyroid-stimulating hormone at 7 d later in both TCDD-sensitive C57BL/6 and TCDD-resistant DBA/2 mice. …
NAID 130003382126

武田知起,服部友紀子,藤井美彩紀 [他],田浦順樹,石井祐次,山田英之,Takeda Tomoki,Hattori Yukiko,fujii Misaki,Taura Junki,Ishii Yuji,Yamada Hideyuki,タケダトモキ,ハットリユキコ,フジイミサキ,タウラジュンキ,イシイユウジ,ヤマダヒデユキ
福岡医学雑誌 = Fukuoka acta medica 104(4), 143-151, 2013-04-25
… Maternal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) causes a number of toxic effects on development such as growth retardation and sexual immaturity in the offspring. …
NAID 120005303402