精巣ホルモン、睾丸ホルモン

WordNet

the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
of or involving the testes; "testicular cancer"

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ホルモン

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1. 精細管内胚細胞腫瘍、未分類（精巣上皮内癌、精巣上皮内腫瘍） testicular intratubular germ cell neoplasia unclassified testicular carcinoma in situ testicular intraepithelial neoplasia
2. 男性不妊症の治療 treatment of male infertility
3. 精巣癌の長期生存者のケアへのアプローチ approach to the care of long term testicular cancer survivors
4. 先天性性腺刺激ホルモン放出ホルモン欠乏症（特発性低ゴナドトロピン性性腺機能低下） congenital gonadotropin releasing hormone deficiency idiopathic hypogonadotropic hypogonadism
5. 去勢感受性転移性前立腺癌の初期療法 initial therapy for castration sensitive metastatic prostate cancer

English Journal

The effect of aggressive rosuvastatin treatment on steroid hormone production in men with coronary artery disease.

Krysiak R1, Okopien B.Author information 1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.AbstractMost steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid hormones may be impaired. The study included 15 men with coronary artery disease, in whom initial statin treatment had been unsuccessful and therefore was replaced with rosuvastatin (20-40 mg daily). Although in 11 patients, rosuvastatin decreased plasma LDL cholesterol levels to below 70 mg/dL, the drug only moderately reduced testosterone levels and increased gonadotropin levels, as well as insignificantly increased plasma ACTH levels. Aggressive rosuvastatin treatment did not affect plasma cortisol and dehydroepiandrosterone sulphate levels, and urine free cortisol. Our results suggest that intensive rosuvastatin treatment is associated with only small changes in adrenal and testicular steroidogenesis.
Basic & clinical pharmacology & toxicology.Basic Clin Pharmacol Toxicol.2014 Apr;114(4):330-5. doi: 10.1111/bcpt.12169. Epub 2013 Dec 11.
Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conve
PMID 24330280

Nigerian bonny light crude oil induces endocrine disruption in male rats.

Adedara IA1, Ebokaiwe AP, Mathur PP, Farombi EO.Author information 1Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan , Ibadan , Nigeria and.AbstractAbstract Exposure to Nigerian bonny light crude oil (BLCO) in the southern part of Nigeria has been reported to be associated with reproductive toxicity, but there is paucity of information on its interference with steroidogenesis. This study investigated the influence of BLCO on testicular steroidogenesis and plasma levels of hormones from the pituitary and thyroid components of the brain-pituitary-testicular axis. Adult male Wistar rats were orally treated with BLCO dissolved in corn oil at 0, 200 and 800 mg/kg for 7 days. Immunoblot analysis revealed that BLCO exposure suppressed steroid acute regulatory protein and androgen-binding protein expression with concomitant decrease in 3β-hydroxysteroid dehydrogenase (HSD) and 17β-hydroxysteroid dehydrogenase activities. BLCO exposure significantly decreased plasma concentrations of follicle-stimulating hormone, luteinizing hormone, prolactin and intratesticular testosterone, but elevated thyrotropin, triiodothyronine and thyroxine above the control values. The data presented herein indicate that undue exposure to BLCO has an inhibitory effect on testicular steroidogenesis. The underlying mechanisms for BLCO-induced testicular dysfunction may involve its disruptive effect on the brain-pituitary-testicular axis. These observations highlight the potential risk to public health for a population where, unfortunately, oil spillages occur frequently.
Drug and chemical toxicology.Drug Chem Toxicol.2014 Apr;37(2):198-203. doi: 10.3109/01480545.2013.834359. Epub 2013 Oct 30.
Abstract Exposure to Nigerian bonny light crude oil (BLCO) in the southern part of Nigeria has been reported to be associated with reproductive toxicity, but there is paucity of information on its interference with steroidogenesis. This study investigated the influence of BLCO on testicular steroido
PMID 24171665

Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats.

Nishizato Y1, Imai S2, Yabunaka A2, Okahashi N3, Kunimatsu T2, Yabuki M2.Author information 1Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., Japan. Electronic address: yohei-nishizato@ds-pharma.co.jp.2Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., Japan.3Research Planning & Intelligence, Dainippon Sumitomo Pharma Co., Ltd., Japan.AbstractSMP-028 is a new compound for treatment of asthma. Oral administration of SMP-028 to rats was associated with toxicological events in endocrine organs. These events mainly consisted of pathological changes in the adrenal gland, testis, prostate, seminal vesicle, ovaries, and uterus. In this study, we set to clarify whether SMP-028 inhibits steroidogenesis in primary culture cells obtained from rat endocrine organs in vitro. Adrenal cells, testicular cells, and ovarian cells were treated with SMP-028 and the production of steroid hormones, i.e., progesterone, aldosterone, corticosterone, total testosterone, and estradiol from these cells was measured by radioimmunoassay. We found that the production of progesterone from these cells treated with SMP-028 at 1μM decreased to 16-67% that of the control. These findings indicate that SMP-028 inhibits steroidogenesis in rat endocrine organs in vitro. Considering that free maximum concentration in rats treated with SMP-028 are higher than the IC50 values for the inhibition of steroidogenesis in vitro, it is therefore believed that the toxicological events seen in rats following treatment with SMP-028 are due to inhibition of steroidogenesis in vivo.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Apr;28(3):397-402. doi: 10.1016/j.tiv.2013.12.005. Epub 2013 Dec 21.
SMP-028 is a new compound for treatment of asthma. Oral administration of SMP-028 to rats was associated with toxicological events in endocrine organs. These events mainly consisted of pathological changes in the adrenal gland, testis, prostate, seminal vesicle, ovaries, and uterus. In this study, w
PMID 24362046

Japanese Journal

Effect of a single injection of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) on testicular blood flow measured by color doppler ultrasonography in male Shiba goats

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Journal of Veterinary Medical Science 77(5), 549-556, 2015
… Although color Doppler ultrasonography has been used to evaluate testicular blood flow in many species, very little has been done in goat. … Eight male Shiba goats were exposed to a single intramuscular injection of either gonadotropin-releasing hormone (GnRH group; …
NAID 130005071873

Cadmium up-regulates transcription of the steroidogenic acute regulatory protein (StAR) gene through phosphorylated CREB rather than SF-1 in K28 cells

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The Journal of Toxicological Sciences 40(2), 151-161, 2015
… In this study, we demonstrated that exposure of K28 mouse testicular Leydig tumor cells to cadmium led to a significant increase in the mRNA level, promoter activity and protein level of the steroidogenic acute regulatory protein (StAR), an essential factor for steroid biosynthesis. … Taken together, these results suggest that cadmium up-regulates StAR gene expression through phosphorylated CREB rather than through SF-1 in mouse testicular Leydig cells. …
NAID 130004904037

Effect of a single injection of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) on testicular blood flow measured by color doppler ultrasonography in male Shiba goats

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Journal of Veterinary Medical Science advpub(0), 2015
… Although color Doppler ultrasonography has been used to evaluate testicular blood flow in many species, very little has been done in goat. … Eight male Shiba goats were exposed to a single intramuscular injection of either gonadotropin-releasing hormone (GnRH group; … The results indicated an increase in testicular blood flow in both groups, as RI and PI decreased significantly (P<0.05), but this increase was significant higher and earlier in hCG group (1 hr) than in the GnRH group (2 hr). …
NAID 130004781094